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International Journal of Diabetes in Developing Countries

Erschienen in:

14.10.2019 | Original Article

Association of advanced glycation end products (AGEs) with endothelial dysfunction, oxidative stress in gestational diabetes mellitus (GDM)

verfasst von: Sundar Krishnasamy, Barathi Rajaraman, Vidya Ravi, Rashmi Rajagopal, Arunkumar Ganeshprasad, Ashok Ayyappa Kuppuswamy, Atima Pathak, C. S. Dhevasena, Krishnan Swaminathan, Mohanraj Sundaresan, Nirupama Ramadas, Srinivasan Vedantham

Erschienen in: International Journal of Diabetes in Developing Countries | Ausgabe 2/2020

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Abstract

Background

Advanced glycation end products (AGEs) are major risk factors for vascular complications in diabetes. Its role in gestational diabetes mellitus (GDM) and vascular complications in GDM is not known.

Objective

The present study was aimed to study the association of AGEs with GDM and vascular inflammation.

Methods

Plasma samples from normal pregnant and GDM women (n = 50 each) were obtained from two tertiary referral centers in Tamil Nadu, India. Quantification of AGEs, methylglyoxal (MGO), ICAM-1, and malondialdehyde (MDA) were performed by commercially available ELISA kits.

Results and conclusions

The third trimester fasting blood sugar (101.35 ± 26.15 vs. 81.63 ± 6.14, p < 0.002) and postprandial blood sugar (150.69 ± 23.07 vs 105.79 ± 11.99, p < 0.0001) were significantly high in GDM women compared to normal pregnant women. The concentrations of AGEs (13.18 ± 8.74, p < 0.001), MGO (15.7 ± 13.54, p < 0.02), and ICAM-1 (217.8 ± 86.92, p = 0.005) were significantly higher in GDM women compared to AGEs (2.68 ± 0.89), MGO (9.26 ± 5.38), and ICAM-1 (142.3 ± 38.21) in normal pregnant women. Further, elevated levels of MDA concentration (0.64 ± 0.08, p < 0.002) and low GSH levels (0.19 ± 0.1, p < 0.0001) in the GDM women were indicative of oxidative stress. AGE levels significantly correlated with MDA concentration which indicates AGEs may be responsible for oxidative stress in GDM women. Further, elevated level of ICAM-1 in GDM women suggests endothelial activation which may impact endothelial function. Thus, AGEs may be used as a biomarker during pregnancy to predict vascular complications due to GDM.

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Titel: Association of advanced glycation end products (AGEs) with endothelial dysfunction, oxidative stress in gestational diabetes mellitus (GDM)
verfasst von: Sundar Krishnasamy
Barathi Rajaraman
Vidya Ravi
Rashmi Rajagopal
Arunkumar Ganeshprasad
Ashok Ayyappa Kuppuswamy
Atima Pathak
C. S. Dhevasena
Krishnan Swaminathan
Mohanraj Sundaresan
Nirupama Ramadas
Srinivasan Vedantham
Publikationsdatum: 14.10.2019
Verlag: Springer India
Erschienen in: International Journal of Diabetes in Developing Countries / Ausgabe 2/2020
Print ISSN: 0973-3930
Elektronische ISSN: 1998-3832
DOI: https://doi.org/10.1007/s13410-019-00766-7

Springer Medizin

Abstract

Background

Objective

Methods

Results and conclusions

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