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Journal of Clinical Immunology

Erschienen in:

01.09.2008

Association of Graves’ Disease and Prevalence of Circulating IFN-γ-producing CD28⁻ T Cells

verfasst von: Zhiping Sun, Weixue Zhong, Xiang Lu, Bimin Shi, Yibei Zhu, Lei Chen, Guangbo Zhang, Xueguang Zhang

Erschienen in: Journal of Clinical Immunology | Ausgabe 5/2008

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Abstract

Background

Peripheral blood CD4⁺ and CD8⁺ T-cell subsets lacking surface CD28 have been suggested to predispose patients to immune-mediated disorders.

Materials and Methods

To determine the role of CD28⁻ T-cell subset in Graves’ disease (GD), we characterized peripheral blood CD4⁺CD28⁻ and CD8⁺CD28⁻ T cell from early onset GD patients.

Results and Discussion

GD patients had significantly higher percentages of CD4⁺CD28⁻ and CD8⁺CD28⁻ T cells than did healthy donors. Both CD28⁻ T cells expressed mostly CD45RO, suggesting that they are activated and/or are memory T cells. GD patient-derived CD4⁺CD28⁻ and CD8⁺CD28⁻ T cells produced more intracellular IFN-γ than their counterparts from healthy donors. Furthermore, CD4⁺CD28⁻ and CD8⁺CD28⁻ T cells from GD patients with Graves’ ophthalmopathy (GO) secreted higher level of intracellular IFN-γ than those CD28⁻ T cells from GD patients without GO. Retrospective analysis showed that the increased levels of CD4⁺CD28⁻ T cells and their IFN-γ-producing subgroups were positively correlated to the serum anti-thyrotropin receptor (TSHR) autoantibodies (TRAb). Our observations suggest that increased IFN-γ-producing CD28⁻ T cells in GD patients may play an important role in the pathogenesis of GD.

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Titel: Association of Graves’ Disease and Prevalence of Circulating IFN-γ-producing CD28− T Cells
verfasst von: Zhiping Sun
Weixue Zhong
Xiang Lu
Bimin Shi
Yibei Zhu
Lei Chen
Guangbo Zhang
Xueguang Zhang
Publikationsdatum: 01.09.2008
Verlag: Springer US
Erschienen in: Journal of Clinical Immunology / Ausgabe 5/2008
Print ISSN: 0271-9142
Elektronische ISSN: 1573-2592
DOI: https://doi.org/10.1007/s10875-008-9213-4

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Abstract

Background

Materials and Methods

Results and Discussion

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