Background
Methods
Study population
Exposure variable
Outcome variable
Covariates
Statistical analysis
Results
Basic characteristics of included participants
Variables | Total (n = 876) | Non-hepatic steatosis group (n = 289) | Hepatic steatosis group (n = 587) | P |
---|---|---|---|---|
Age, years, Mean (S.E) | 52.37 (1.18) | 51.61 (2.01) | 52.75 (1.10) | 0.544 |
Gender, n (%) | 0.103 | |||
Male | 407 (50.07) | 109 (44.28) | 298 (52.98) | |
Female | 469 (49.93) | 180 (55.72) | 289 (47.02) | |
Race, n (%) | 0.455 | |||
Mexican American | 154 (11.52) | 37 (8.13) | 117 (13.22) | |
Other Hispanic | 96 (6.79) | 31 (6.63) | 65 (6.87) | |
Non-Hispanic White | 308 (62.25) | 100 (63.26) | 208 (61.75) | |
Non-Hispanic Black | 162 (8.86) | 66 (10.20) | 96 (8.19) | |
Other Race | 156 (10.58) | 55 (11.78) | 101 (9.97) | |
Education level, n (%) | 0.004 | |||
High school degree or less | 222 (15.10) | 86 (21.24) | 136 (12.02) | |
High school education | 214 (32.53) | 52 (22.83) | 162 (37.41) | |
High school degree or above | 429 (51.71) | 147 (55.16) | 282 (49.98) | |
Unknown | 11 (0.65) | 4 (0.77) | 7 (0.59) | |
Family PIR, Mean (S.E) | 2.80 (0.10) | 2.76 (0.15) | 2.81 (0.14) | 0.790 |
Drinking status, n (%) | 0.871 | |||
No | 116 (9.73) | 48 (10.07) | 68 (9.56) | |
Yes | 760 (90.27) | 241 (89.93) | 519 (90.44) | |
Smoking status, n (%) | 0.875 | |||
Never smoked | 457 (49.28) | 158 (47.95) | 299 (49.95) | |
Used to smoke and now quit | 255 (30.88) | 74 (30.90) | 181 (30.86) | |
Still smoking | 164 (19.85) | 57 (21.16) | 107 (19.19) | |
Physical activity, n (%) | 0.708 | |||
≤ 750 MET∙min | 605 (61.46) | 210 (62.89) | 395 (60.74) | |
> 750 MET∙min | 271 (38.54) | 79 (37.12) | 192 (39.26) | |
SBP, mmHg, Mean (S.E) | 131.37 (0.63) | 129.69 (1.62) | 132.22 (1.00) | 0.290 |
DBP, mmHg, Mean (S.E) | 76.09 (0.64) | 76.44 (1.27) | 75.91 (0.63) | 0.700 |
Hepatitis, n (%) | 0.025 | |||
No | 797 (93.57) | 254 (89.25) | 543 (95.75) | |
Yes | 79 (6.43) | 35 (10.75) | 44 (4.26) | |
CKD, n (%) | 0.652 | |||
No | 811 (95.27) | 266 (94.57) | 545 (95.62) | |
Yes | 65 (4.73) | 23 (5.43) | 42 (4.38) | |
CVD, n (%) | 0.011 | |||
No | 592 (71.57) | 210 (79.72) | 382 (67.48) | |
Yes | 284 (28.43) | 79 (20.28) | 205 (32.52) | |
ALT, U/L, Mean (S.E) | 27.25 (1.04) | 23.34 (1.49) | 29.21 (1.15) | 0.004 |
AST, U/L, Mean (S.E) | 23.48 (0.81) | 22.40 (1.63) | 24.02 (0.92) | 0.408 |
ALP, IU/L, Mean (S.E) | 81.61 (0.83) | 83.04 (2.41) | 80.90 (1.11) | 0.494 |
GGT, IU/L, Mean (S.E) | 36.13 (1.94) | 33.41 (3.41) | 37.50 (2.06) | 0.281 |
TC, mg/dL, Mean (S.E) | 191.01 (3.62) | 190.37 (2.84) | 191.32 (4.54) | 0.808 |
LDL-C, mg/dL, Mean (S.E) | 114.49 (2.57) | 113.35 (2.18) | 115.06 (3.29) | 0.591 |
Hs-CRP, mg/L, Mean (S.E) | 5.22 (0.50) | 5.19 (1.32) | 5.23 (0.36) | 0.978 |
Platelet count, 1000 cells/uL, Mean (S.E) | 245.33 (3.66) | 249.42 (4.61) | 243.28 (4.37) | 0.271 |
Total bilirubin, umol/L, Mean (S.E) | 8.12 (0.24) | 8.04 (0.46) | 8.16 (0.29) | 0.839 |
Serum creatinine, mg/dL, Mean (S.E) | 0.87 (0.01) | 0.87 (0.02) | 0.87 (0.01) | 0.685 |
Urinary creatinine, mg/dL, Mean (S.E) | 139.13 (5.45) | 126.81 (10.49) | 145.33 (4.25) | 0.086 |
Serum ALB, g/L, Mean (S.E) | 39.79 (0.26) | 39.67 (0.39) | 39.86 (0.32) | 0.711 |
Urinary ALB, mg/L, Mean (S.E) | 57.03 (8.94) | 53.57 (14.45) | 58.77 (11.72) | 0.789 |
Drug for diabetes, n (%) | 0.028 | |||
No | 634 (77.36) | 227 (83.91) | 407 (74.07) | |
Yes | 242 (22.64) | 62 (16.09) | 180 (25.93) | |
Drug for hypertension, n (%) | 0.013 | |||
No | 472 (57.54) | 164 (66.39) | 308 (53.09) | |
Yes | 404 (42.46) | 125 (33.62) | 279 (46.91) | |
Drug for dyslipidemia, n (%) | 0.129 | |||
No | 591 (69.83) | 206 (75.00) | 385 (67.23) | |
Yes | 285 (30.17) | 83 (25.00) | 202 (32.77) | |
Antiviral agents, n (%) | 0.986 | |||
No | 874 (99.92) | 288 (99.92) | 586 (99.92) | |
Yes | 2 (0.08) | 1 (0.08) | 1 (0.08) | |
Glucocorticoids, n (%) | 0.897 | |||
No | 854 (97.73) | 281 (97.83) | 573 (97.68) | |
Yes | 22 (2.27) | 8 (2.17) | 14 (2.32) | |
Drug induce hepatic steatosis n (%) | 0.129 | |||
No | 859 (97.67) | 279 (96.00) | 580 (98.50) | |
Yes | 17 (2.33) | 10 (4.00) | 7 (1.50) | |
Energy, Mean (S.E) | 2220.76 (50.98) | 2126.94 (75.22) | 2267.91 (67.43) | 0.194 |
Carbohydrate, Mean (S.E) | 258.88 (6.21) | 252.72 (7.69) | 261.97 (8.27) | 0.415 |
Protein, Mean (S.E) | 83.54 (2.04) | 76.39 (3.03) | 87.14 (2.79) | 0.030 |
Total fat, Mean (S.E) | 91.19 (2.41) | 85.05 (4.41) | 94.28 (3.09) | 0.126 |
Vitamin E, Mean (S.E) | 0.67 (0.18) | 0.92 (0.45) | 0.55 (0.15) | 0.451 |
METS-IR, Mean (S.E) | 53.19 (1.03) | 47.68 (1.09) | 55.96 (0.95) | < 0.001 |
TyG index, Mean (S.E) | 9.14 (0.04) | 8.97 (0.05) | 9.22 (0.06) | 0.006 |
HOMA-IR, Mean (S.E) | 6.49 (0.37) | 4.32 (0.40) | 7.58 (0.52) | < 0.001 |
TyG-WHtR, Mean (S.E) | 6.05 (0.07) | 5.62 (0.07) | 6.27 (0.07) | < 0.001 |
Variables | Total (n = 876) | Non-hepatic fibrosis group (n = 725) | Hepatic fibrosis group (n = 151) | P |
---|---|---|---|---|
Age, years, Mean (S.E) | 52.37 (1.18) | 52.11 (1.14) | 53.83 (2.24) | 0.379 |
Gender, n (%) | 0.687 | |||
Male | 407 (50.07) | 325 (50.58) | 82 (47.24) | |
Female | 469 (49.93) | 400 (49.42) | 69 (52.77) | |
Race, n (%) | 0.606 | |||
Mexican American | 154 (11.52) | 128 (11.30) | 26 (12.75) | |
Other Hispanic | 96 (6.79) | 76 (6.25) | 20 (9.84) | |
Non-Hispanic White | 308 (62.25) | 254 (62.50) | 54 (60.90) | |
Non-Hispanic Black | 162 (8.86) | 138 (9.23) | 24 (6.83) | |
Other Race | 156 (10.58) | 129 (10.73) | 27 (9.69) | |
Education level, n (%) | 0.248 | |||
High school degree or less | 222 (15.10) | 191 (15.54) | 31 (12.68) | |
High school education | 214 (32.53) | 176 (31.26) | 38 (39.69) | |
High school degree or above | 429 (51.71) | 351 (52.67) | 78 (46.34) | |
Unknown | 11 (0.65) | 7 (0.53) | 4 (1.30) | |
Family PIR, Mean (S.E) | 2.80 (0.10) | 2.86 (0.11) | 2.45 (0.16) | 0.040 |
Drinking status, n (%) | 0.031 | |||
No | 116 (9.73) | 93 (8.52) | 23 (16.51) | |
Yes | 760 (90.27) | 632 (91.48) | 128 (83.49) | |
Smoking status, n (%) | 0.556 | |||
Never smoked | 457 (49.28) | 391 (50.05) | 66 (44.98) | |
Used to smoke and now quit | 255 (30.88) | 200 (29.90) | 55 (36.34) | |
Still smoking | 164 (19.85) | 134 (20.05) | 30 (18.68) | |
Physical activity, n (%) | 0.092 | |||
≤ 750 MET∙ min | 605 (61.46) | 495 (59.54) | 110 (72.21) | |
> 750 MET∙ min | 271 (38.54) | 230 (40.46) | 41 (27.79) | |
SBP, mmHg, Mean (S.E) | 131.37 (0.63) | 131.38 (0.67) | 131.31 (2.01) | 0.974 |
DBP, mmHg, Mean (S.E) | 76.09 (0.64) | 76.75 (0.75) | 72.36 (1.48) | 0.023 |
Hepatitis, n (%) | 0.345 | |||
No | 797 (93.57) | 663 (94.18) | 134 (90.18) | |
Yes | 79 (6.43) | 62 (5.82) | 17 (9.83) | |
CKD, n (%) | 0.055 | |||
No | 811 (95.27) | 678 (95.80) | 133 (92.32) | |
Yes | 65 (4.73) | 47 (4.20) | 18 (7.68) | |
CVD, n (%) | 0.013 | |||
No | 592 (71.57) | 506 (74.23) | 86 (56.71) | |
Yes | 284 (28.43) | 219 (25.77) | 65 (43.29) | |
ALT, U/L, Mean (S.E) | 27.25 (1.04) | 25.62 (0.99) | 36.35 (3.05) | 0.003 |
AST, U/L, Mean (S.E) | 23.48 (0.81) | 22.03 (0.73) | 31.56 (3.27) | 0.011 |
ALP, IU/L, Mean (S.E) | 81.61 (0.83) | 80.95 (1.10) | 85.32 (3.74) | 0.334 |
GGT, IU/L, Mean (S.E) | 36.13 (1.94) | 32.75 (1.57) | 55.06 (6.87) | 0.005 |
TC, mg/dL, Mean (S.E) | 191.01 (3.62) | 191.97 (3.35) | 185.58 (6.05) | 0.153 |
LDL-C, mg/dL, Mean (S.E) | 114.49 (2.57) | 115.17 (2.32) | 110.62 (5.13) | 0.281 |
Hs-CRP, mg/L, Mean (S.E) | 5.22 (0.50) | 4.95 (0.57) | 6.71 (1.09) | 0.174 |
Platelet count, 1000 cells/uL, Mean (S.E) | 245.33 (3.66) | 247.28 (4.06) | 234.42 (4.97) | 0.031 |
Total bilirubin, umol/L, Mean (S.E) | 8.12 (0.24) | 8.01 (0.25) | 8.70 (0.37) | 0.087 |
Serum creatinine, mg/dL, Mean (S.E) | 0.87 (0.01) | 0.87 (0.01) | 0.87 (0.03) | 0.892 |
Urinary creatinine, mg/dL, Mean (S.E) | 139.13 (5.45) | 139.34 (6.58) | 137.99 (12.73) | 0.933 |
Serum ALB, g/L, Mean (S.E) | 39.79 (0.26) | 39.96 (0.23) | 38.85 (0.47) | 0.008 |
Urinary ALB, mg/L, Mean (S.E) | 57.03 (8.94) | 45.93 (7.36) | 119.26 (32.68) | 0.036 |
Drug for diabetes, n (%) | < 0.001 | |||
No | 634 (77.36) | 553 (80.49) | 81 (59.81) | |
Yes | 242 (22.64) | 172 (19.51) | 70 (40.19) | |
Drug for hypertension, n (%) | 0.329 | |||
No | 472 (57.54) | 409 (59.01) | 63 (49.30) | |
Yes | 404 (42.46) | 316 (40.99) | 88 (50.71) | |
Drug for dyslipidemia, n (%) | 0.934 | |||
No | 591 (69.83) | 500 (69.76) | 91 (70.23) | |
Yes | 285 (30.17) | 225 (30.24) | 60 (29.77) | |
Antiviral agents, n (%) | ||||
No | 874 (99.92) | 723 (99.91) | 151 (100.00) | |
Yes | 2 (0.08) | 2 (0.10) | 0 (0.00) | |
Glucocorticoids, n (%) | 0.018 | |||
No | 854 (97.73) | 705 (97.42) | 149 (99.45) | |
Yes | 22 (2.27) | 20 (2.58) | 2 (0.55) | |
Drug induce hepatic steatosis n (%) | 0.666 | |||
No | 859 (97.67) | 710 (97.81) | 149 (96.84) | |
Yes | 17 (2.33) | 15 (2.19) | 2 (3.16) | |
Energy, Mean (S.E) | 2220.76 (50.98) | 2230.40 (53.05) | 2166.76 (106.88) | 0.565 |
Carbohydrate, Mean (S.E) | 258.88 (6.21) | 261.61 (6.74) | 243.59 (15.49) | 0.304 |
Protein, Mean (S.E) | 83.54 (2.04) | 83.31 (2.41) | 84.85 (5.29) | 0.809 |
Total fat, Mean (S.E) | 91.19 (2.41) | 91.22 (2.66) | 91.03 (4.93) | 0.972 |
Vitamin E, Mean (S.E) | 0.67 (0.18) | 0.70 (0.21) | 0.53 (0.28) | 0.629 |
METS-IR, Mean (S.E) | 53.19 (1.03) | 51.64 (0.84) | 61.89 (1.92) | < 0.001 |
TyG index, Mean (S.E) | 9.14 (0.04) | 9.11 (0.05) | 9.27 (0.07) | 0.097 |
HOMA-IR, Mean (S.E) | 6.49 (0.37) | 5.76 (0.30) | 10.56 (1.98) | 0.036 |
TyG-WHtR, Mean (S.E) | 6.05 (0.07) | 5.92 (0.06) | 6.79 (0.12) | < 0.001 |
Association between IR indicators and both hepatic steatosis, hepatic fibrosis
Indicators | Hepatic steatosis | Hepatic fibrosis | ||||||
---|---|---|---|---|---|---|---|---|
Crude Model | Adjusted Modela | Crude Model | Adjusted Modelb | |||||
OR (95% CI) | P | OR (95% CI) | P | OR (95% CI) | P | OR (95% CI) | P | |
HOMA-IR | ||||||||
< 3.11 | Ref | Ref | Ref | Ref | ||||
3.11–5.81 | 2.41 (1.17–4.94) | 0.020 | 2.36 (1.14–4.87) | 0.023 | 3.29 (1.16–9.37) | 0.028 | 2.84 (0.95–8.50) | 0.060 |
≥ 5.81 | 5.30 (2.65–10.62) | < 0.001 | 4.54 (2.06–10.03) | 0.001 | 7.25 (3.34–15.76) | < 0.001 | 4.47 (1.87–10.66) | 0.002 |
TyG | ||||||||
< 8.90 | Ref | Ref | Ref | Ref | ||||
8.90–9.30 | 1.12 (0.58–2.15) | 0.726 | 1.11 (0.61–2.02) | 0.708 | 0.87 (0.37–2.01) | 0.724 | 0.72 (0.33–1.57) | 0.383 |
≥ 9.30 | 2.28 (1.10–4.74) | 0.030 | 2.24 (1.15–4.39) | 0.021 | 1.41 (0.58–3.41) | 0.420 | 0.79 (0.30–2.09) | 0.610 |
TyG-WHtR | ||||||||
< 5.55 | Ref | Ref | Ref | Ref | ||||
5.55–6.29 | 2.77 (1.48–5.19) | 0.003 | 2.23 (1.17–4.24) | 0.018 | 2.34 (1.05–5.20) | 0.039 | 1.53 (0.49–4.73) | 0.439 |
≥ 6.29 | 7.01 (4.24–11.57) | < 0.001 | 6.07 (3.74–9.83) | < 0.001 | 11.42 (5.89–22.15) | < 0.001 | 9.21 (2.90–29.22) | < 0.001 |
METS-IR | ||||||||
< 46.27 | Ref | Ref | Ref | Ref | ||||
46.27–57.04 | 1.49 (0.85–2.60) | 0.148 | 1.53 (0.78–2.99) | 0.200 | 1.05 (0.46–2.43) | 0.900 | 1.28 (0.67–2.48) | 0.428 |
≥ 57.04 | 6.27 (4.00–9.81) | < 0.001 | 5.60 (3.34–9.40) | < 0.001 | 4.61 (2.25–9.44) | < 0.001 | 5.04 (2.47–10.27) | < 0.001 |
Diagnostic value of IR indicators in identifying hepatic steatosis and fibrosis
Variables | Indicators | AUC (95%CI) | Sensitivity (95%CI) | Specificity (95%CI) | NPV (95%CI) | PPV (95%CI) | Accuracy (95%CI) |
---|---|---|---|---|---|---|---|
Hepatic steatosis | HOMA-IR | 0.693 (0.656–0.730) | 0.618 (0.578–0.658) | 0.685 (0.628–0.738) | 0.469 (0.421–0.518) | 0.800 (0.760–0.835) | 0.640 (0.608–0.672) |
TyG | 0.627 (0.587–0.666) | 0.828 (0.795–0.858) | 0.377 (0.321–0.436) | 0.519 (0.449–0.588) | 0.730 (0.694–0.763) | 0.679 (0.647–0.710) | |
TyG-WHtR | 0.705 (0.668–0.743) | 0.676 (0.637–0.714) | 0.640 (0.582–0.696) | 0.493 (0.442–0.545) | 0.792 (0.754–0.827) | 0.664 (0.632–0.696) | |
METS-IR | 0.685 (0.648–0.722) | 0.404 (0.364–0.445) | 0.862 (0.816–0.899) | 0.416 (0.376–0.456) | 0.856 (0.809–0.895) | 0.555 (0.521–0.588) | |
Hepatic fibrosis | HOMA-IR | 0.682 (0.635–0.729) | 0.603 (0.520–0.681) | 0.708 (0.673–0.740) | 0.895 (0.867–0.919) | 0.300 (0.249–0.355) | 0.689 (0.658–0.720) |
TyG | 0.542 (0.489–0.594) | 0.576 (0.493–0.656) | 0.506 (0.469–0.543) | 0.852 (0.814–0.884) | 0.196 (0.160–0.235) | 0.518 (0.485–0.552) | |
TyG-WHtR | 0.703 (0.655–0.751) | 0.629 (0.547–0.706) | 0.712 (0.677–0.744) | 0.902 (0.875–0.925) | 0.313 (0.261–0.368) | 0.697 (0.666–0.728) | |
METS-IR | 0.682 (0.632–0.731) | 0.589 (0.507–0.669) | 0.709 (0.674–0.742) | 0.892 (0.864–0.916) | 0.297 (0.246–0.352) | 0.688 (0.657–0.719) |
Subgroup analysis
Variables | Hepatic steatosisa | Hepatic fibrosisb | ||
---|---|---|---|---|
Adjusted Model | Adjusted Model | |||
OR (95% CI) | P | OR (95% CI) | P | |
Age < 60 years (n = 479) | ||||
HOMA-IR | ||||
< 3.11 | Ref | Ref | ||
3.11–5.81 | 2.08 (0.94–4.62) | 0.070 | 3.77 (0.75–18.97) | 0.100 |
≥ 5.81 | 3.74 (1.35–10.36) | 0.015 | 5.31 (1.29–21.83) | 0.024 |
TyG | ||||
< 8.90 | Ref | Ref | ||
8.90–9.30 | 1.23 (0.55–2.73) | 0.592 | 0.40 (0.16–1.05) | 0.060 |
≥ 9.30 | 2.27 (0.94–5.50) | 0.067 | 0.58 (0.15–2.23) | 0.404 |
TyG-WHtR | ||||
< 5.55 | Ref | Ref | ||
5.55–6.29 | 2.01 (0.94–4.31) | 0.069 | 0.99 (0.17–5.79) | 0.987 |
≥ 6.29 | 6.33 (3.31–12.08) | < 0.001 | 11.72 (2.65–51.92) | 0.003 |
METS-IR | ||||
< 46.27 | Ref | Ref | ||
46.27–57.04 | 1.37 (0.70–2.67) | 0.329 | 4.56 (1.51–13.78) | 0.010 |
≥ 57.04 | 5.01 (2.63–9.55) | < 0.001 | 16.55 (4.00–68.38) | <.001 |
Age ≥ 60 years (n = 397) | ||||
HOMA-IR | ||||
< 3.11 | Ref | Ref | ||
3.11–5.81 | 3.73 (1.07–13.06) | 0.041 | 1.46 (0.53–4.08) | 0.440 |
≥ 5.81 | 12.30 (4.33–34.92) | < 0.001 | 3.36 (0.97–11.65) | 0.055 |
TyG | ||||
< 8.90 | Ref | Ref | ||
8.90–9.30 | 1.09 (0.45–2.65) | 0.835 | 1.12 (0.31–4.05) | 0.854 |
≥ 9.30 | 2.43 (0.86–6.92) | 0.089 | 0.84 (0.30–2.36) | 0.726 |
TyG-WHtR | ||||
< 5.55 | Ref | Ref | ||
5.55–6.29 | 3.50 (1.59–7.72) | 0.004 | 1.96 (0.59–6.52) | 0.250 |
≥ 6.29 | 6.38 (2.88–14.14) | < 0.001 | 6.47 (2.14–19.60) | 0.003 |
METS-IR | ||||
< 46.27 | Ref | Ref | ||
46.27–57.04 | 2.20 (0.94–5.19) | 0.068 | 0.97 (0.29–3.29) | 0.958 |
≥ 57.04 | 9.30 (4.45–19.46) | < 0.001 | 3.58 (1.38–9.25) | 0.012 |
Gender-male (n = 407) | ||||
HOMA-IR | ||||
< 3.11 | Ref | Ref | ||
3.11–5.81 | 3.36 (1.31–8.61) | 0.015 | 3.15 (0.95–10.41) | 0.059 |
≥ 5.81 | 8.74 (3.15–24.19) | < 0.001 | 4.62 (1.75–12.23) | 0.004 |
TyG | ||||
< 8.90 | Ref | Ref | ||
8.90–9.30 | 1.14 (0.33–3.89) | 0.829 | 0.96 (0.32–2.83) | 0.930 |
≥ 9.30 | 1.96 (0.64–5.96) | 0.218 | 1.00 (0.24–4.23) | 0.999 |
TyG-WHtR | ||||
< 5.55 | Ref | Ref | ||
5.55–6.29 | 2.87 (1.58–5.22) | 0.002 | 1.47 (0.30–7.23) | 0.614 |
≥ 6.29 | 23.36 (9.59–56.87) | < 0.001 | 11.14 (2.05–60.51) | 0.008 |
METS-IR | ||||
< 46.27 | Ref | Ref | ||
46.27–57.04 | 2.41 (0.84–6.89) | 0.095 | 0.51 (0.20–1.34) | 0.159 |
≥ 57.04 | 11.42 (3.87–33.70) | < 0.001 | 4.47 (1.49–13.41) | 0.011 |
Gender-female (n = 469) | ||||
HOMA-IR | ||||
< 3.11 | Ref | Ref | ||
3.11–5.81 | 1.97 (0.91–4.25) | 0.079 | 2.89 (0.57–14.69) | 0.185 |
≥ 5.81 | 3.61 (1.56–8.36) | 0.005 | 4.92 (1.18–20.45) | 0.031 |
TyG | ||||
< 8.90 | Ref | Ref | ||
8.90–9.30 | 1.22 (0.59–2.54) | 0.568 | 0.41 (0.15–1.12) | 0.077 |
≥ 9.30 | 2.94 (1.54–5.62) | 0.003 | 0.60 (0.16–2.20) | 0.415 |
TyG-WHtR | ||||
< 5.55 | Ref | Ref | ||
5.55–6.29 | 2.09 (0.94–4.64) | 0.068 | 1.31 (0.24–7.03) | 0.737 |
≥ 6.29 | 4.88 (2.33–10.21) | < 0.001 | 8.78 (2.02–38.27) | 0.007 |
METS-IR | ||||
< 46.27 | Ref | Ref | ||
46.27–57.04 | 0.94 (0.42–2.15) | 0.885 | 3.40 (1.20–9.58) | 0.024 |
≥ 57.04 | 3.82 (2.12–6.90) | < 0.001 | 7.96 (2.27–27.91) | 0.003 |