Skip to main content

01.07.2014 | Genetics | Ausgabe 7/2014

Journal of Assisted Reproduction and Genetics 7/2014

Association of the IL4R single-nucleotide polymorphism I50V with recurrent spontaneous abortion (RSA)

Journal of Assisted Reproduction and Genetics > Ausgabe 7/2014
Fataneh Tavasolian, Elham Abdollahi, Morteza Samadi
Wichtige Hinweise
Capsule Immunological disorder is a possible reason for Recurrent spontaneous abortion (RSA). I50V as a immunological genetic variant has no association with RSA. This is first report of frequency of I50V in RSA patients and related controls.



Recurrent spontaneous abortion (RSA) is defined as three or more consecutive abortions before the 20th week of gestation. There is increasing evidence to support an immunological mechanism for the occurrence of RSA. The purpose of our study was to examine whether single-nucleotide polymorphisms (SNPs) of the interleukin-4 receptor gene IL4R influence susceptibility to, recurrent spontaneous abortion.

Materials and methods

This is a case-control study. We recruited 200 patients with RSA (case group) using established diagnostic criteria and 200, normal individuals (control group) at the fertility and infertility center in Yazd city and Isfahan city during 2012 to 2013. We screened the I50V variant in IL-4R in patients and controls by PCR-RFLF method, and we performed an association analysis between I50V variant and RSA.the data was analyzed by spss 16 software using Chi-square test.


No differences in the genotype and allele frequencies of the I50V SNPs were identified between patients with RSA and healthy controls.


The frequency of SNP in IL-4 receptor (I50V) in patients with recurrent spontaneous abortion did not differ significantly compared with the control group. Analysis of IL4R SNP haplotypes or complex alleles suggested no dominant protection in patients with RSA.

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

e.Med Interdisziplinär

Mit e.Med Interdisziplinär erhalten Sie Zugang zu allen CME-Fortbildungen und Fachzeitschriften auf

Weitere Produktempfehlungen anzeigen
Über diesen Artikel

Weitere Artikel der Ausgabe 7/2014

Journal of Assisted Reproduction and Genetics 7/2014 Zur Ausgabe
  1. Sie können e.Med Gynäkologie & Urologie 14 Tage kostenlos testen (keine Print-Zeitschrift enthalten). Der Test läuft automatisch und formlos aus. Es kann nur einmal getestet werden.

Neu im Fachgebiet Gynäkologie und Geburtshilfe

Mail Icon II Newsletter

Bestellen Sie unseren kostenlosen Newsletter Update Gynäkologie und bleiben Sie gut informiert – ganz bequem per eMail.