Skip to main content
Hauptrubriken
CME Facharzt-Training Webinare Zeitschriften Bücher e.Medpedia Podcast
Service
Jobbörse Info & Hilfe
Fachgebiete
Anästhesiologie Allgemeinmedizin Arbeitsmedizin Augenheilkunde Chirurgie Dermatologie Gynäkologie und Geburtshilfe HNO Innere Medizin Kardiologie Neurologie Onkologie und Hämatologie Orthopädie und Unfallchirurgie Pädiatrie Pathologie Psychiatrie Radiologie Rechtsmedizin Urologie Zahnmedizin
Themen
Klimawandel und Gesundheit Neues aus dem Markt COVID-19 Praxis und Beruf Seltene Erkrankungen GOÄ & EBM Panorama
Sammlungen
Kasuistiken Algorithmen & Infografiken Blickdiagnosen Arthropedia FlapFinder (für Dermatochirurgen) Videos Kongressberichterstattung Medizin für Apothekerinnen und Apotheker Für Ärztinnen und Ärzte in Weiterbildung Für Medizinstudierende
Erweiterte Suche
Anmelden
nach oben
Journal of Assisted Reproduction and Genetics
Erschienen in: Journal of Assisted Reproduction and Genetics 7/2014

01.07.2014 | Genetics

Association of the IL4R single-nucleotide polymorphism I50V with recurrent spontaneous abortion (RSA)

verfasst von: Fataneh Tavasolian, Elham Abdollahi, Morteza Samadi

Erschienen in: Journal of Assisted Reproduction and Genetics | Ausgabe 7/2014

Einloggen, um Zugang zu erhalten

Abstract

Background

Recurrent spontaneous abortion (RSA) is defined as three or more consecutive abortions before the 20th week of gestation. There is increasing evidence to support an immunological mechanism for the occurrence of RSA. The purpose of our study was to examine whether single-nucleotide polymorphisms (SNPs) of the interleukin-4 receptor gene IL4R influence susceptibility to, recurrent spontaneous abortion.

Materials and methods

This is a case-control study. We recruited 200 patients with RSA (case group) using established diagnostic criteria and 200, normal individuals (control group) at the fertility and infertility center in Yazd city and Isfahan city during 2012 to 2013. We screened the I50V variant in IL-4R in patients and controls by PCR-RFLF method, and we performed an association analysis between I50V variant and RSA.the data was analyzed by spss 16 software using Chi-square test.

Results

No differences in the genotype and allele frequencies of the I50V SNPs were identified between patients with RSA and healthy controls.

Conclusions

The frequency of SNP in IL-4 receptor (I50V) in patients with recurrent spontaneous abortion did not differ significantly compared with the control group. Analysis of IL4R SNP haplotypes or complex alleles suggested no dominant protection in patients with RSA.
Literatur
1.
Lim KJ, Odukoya OA, Ajjan RA, Li T-C, Weetman AP, Cooke ID. The role of T-helper cytokines in human reproduction. Fertil Steril. 2000;73(1):136–42.PubMedCrossRef
2.
Lunghi L, Ferretti ME, Medici S, Biondi C, Vesce F. Control of human trophoblast function. Reprod Biol Endocrinol. 2007;5(6).
3.
Raghupathy R, Makhseed M, Azizieh F, Omu A, Gupta M, Farhat R. Cytokine production by maternal lymphocytes during normal human pregnancy and in unexplained recurrent spontaneous abortion. Hum Reprod. 2000;15(3):713–8.PubMedCrossRef
4.
Rezaei A, Dabbagh A. T-helper (1) cytokines increase during early pregnancy in women with a history of recurrent spontaneous abortion. Med Sci Monit. 2002;8(8):CR607–CR10.PubMed
5.
Sasaki Y, Sakai M, Miyazaki S, Higuma S, Shiozaki A, Saito S. Decidual and peripheral blood CD4+ CD25+ regulatory T cells in early pregnancy subjects and spontaneous abortion cases. Mol Hum Reprod. 2004;10(5):347–53.PubMedCrossRef
6.
Bettelli E, Carrier Y, Gao W, Korn T, Strom TB, Oukka M, et al. Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells. Nature. 2006;441(7090):235–8.PubMedCrossRef
7.
Saito S, Nakashima A, Shima T, Ito MREVIEWARTICLE. Th1/Th2/Th17 and Regulatory T‐Cell Paradigm in Pregnancy. Am J Reprod Immunol. 2010;63(6):601–10.PubMedCrossRef
8.
Nakashima A, Ito M, Yoneda S, Shiozaki A, Hidaka T, Saito S. SHORT COMMUNICATION: Circulating and Decidual Th17 Cell Levels in Healthy Pregnancy. Am J Reprod Immunol. 2010;63(2):104–9.PubMedCrossRef
9.
Korn T, Mitsdoerffer M, Croxford AL, Awasthi A, Dardalhon VA, Galileos G, et al. IL-6 controls Th17 immunity in vivo by inhibiting the conversion of conventional T cells into Foxp3+ regulatory T cells. Proc Natl Acad Sci. 2008;105(47):18460–5.PubMedCentralPubMedCrossRef
10.
Steinman L. A brief history of TH17, the first major revision in the TH1/TH2 hypothesis of T cell–mediated tissue damage. Nat Med. 2007;13(2):139–45.PubMedCrossRef
11.
Afzali B, Lombardi G, Lechler R, Lord G. The role of T helper 17 (Th17) and regulatory T cells (Treg) in human organ transplantation and autoimmune disease. Clin Exp Immunol. 2007;148(1):32–46.PubMedCentralPubMedCrossRef
12.
Wang W-J, Hao C-F, Yin G-J, Bao S-H, Qiu L-H, Lin Q-D. Increased prevalence of T helper 17 (Th17) cells in peripheral blood and decidua in unexplained recurrent spontaneous abortion patients. J Reprod Immunol. 2010;84(2):164–70.PubMedCrossRef
13.
Kruse S, Japha T, Tedner M, Sparholt S, Forster J, Kuehr J, et al. The polymorphisms S503P and Q576R in the interleukin-4 receptor gene are associated with atopy and influence the signal transduction. IMMUNOL-OXFORD-. 1999;96:365–71.CrossRef
14.
Risma KA, Wang N, Andrews RP, Cunningham CM, Ericksen MB, Bernstein JA, et al. V75R576 IL-4 receptor α is associated with allergic asthma and enhanced IL-4 receptor function. J Immunol. 2002;169(3):1604–10.PubMedCrossRef
15.
Mellor A, Munn D. Immunology at the maternal-fetal interface: lessons for T cell tolerance and suppression. Annu Rev Immunol. 2000;18(1):367–91.PubMedCrossRef
16.
Soares MJ. The prolactin and growth hormone families: pregnancy-specific hormones/cytokines at the maternal-fetal interface. Reprod Biol Endocrinol. 2004;2(10.1186):1477–7827.
17.
Kwak‐Kim J, Yang KM, Gilman‐Sachs A. Recurrent pregnancy loss: a disease of inflammation and coagulation. J Obstet Gynaecol Res. 2009;35(4):609–22.PubMedCrossRef
18.
Boyson JE, Rybalov B, Koopman LA, Exley M, Balk SP, Racke FK, et al. CD1d and invariant NKT cells at the human maternal–fetal interface. Proc Natl Acad Sci. 2002;99(21):13741–6.PubMedCentralPubMedCrossRef
19.
Entrican G. Immune regulation during pregnancy and host–pathogen interactions in infectious abortion. J Comp Pathol. 2002;126(2):79–94.PubMedCrossRef
20.
Hunt JS, Petroff MG, McIntire RH, Ober C. HLA-G and immune tolerance in pregnancy. FASEB J. 2005;19(7):681–93.PubMedCrossRef
21.
Korn T, Bettelli E, Oukka M, Kuchroo VK. IL-17 and Th17 Cells. Annu Rev Immunol. 2009;27:485–517.PubMedCrossRef
22.
Mandal M, Marzouk AC, Donnelly R, Ponzio NM. Maternal immune stimulation during pregnancy affects adaptive immunity in offspring to promote development of TH17 cells. Brain Behav Immun. 2011;25(5):863–71.PubMedCrossRef
23.
Lee SK, Kim JY, Lee M. Gilman‐Sachs A, Kwak‐Kim J. Th17 and regulatory T cells in women with recurrent pregnancy loss. Am J Reprod Immunol. 2012;67(4):311–8.PubMedCrossRef
24.
Numasaki M. Fukushi J-i, Ono M, Narula SK, Zavodny PJ, Kudo T, et al. Interleukin-17 promotes angiogenesis and tumor growth. Blood. 2003;101(7):2620–7.PubMedCrossRef
25.
Pongcharoen S, Somran J, Sritippayawan S, Niumsup P, Chanchan P, Butkhamchot P, et al. Interleukin-17 expression in the human placenta. Placenta. 2007;28(1):59–63.PubMedCrossRef
26.
Liu YS, Wu L, Tong XH, Wu LM, He GP, Zhou GX, et al. Study on the relationship between Th17 cells and unexplained recurrent spontaneous abortion. Am J Reprod Immunol. 2011;65(5):503–11.PubMedCrossRef
27.
NG SC, GILMAN‐SACHS A, THAKER P, BEAMAN KD, BEER AE, KWAK‐KIM J. Expression of intracellular Th1 and Th2 cytokines in women with recurrent spontaneous abortion, implantation failures after IVF/ET or normal pregnancy. Am J Reprod Immunol. 2002;48(2):77–86.PubMedCrossRef
28.
Lee YK, Mukasa R, Hatton RD, Weaver CT. Developmental plasticity of Th17 and Treg cells. Curr Opin Immunol. 2009;21(3):274–80.PubMedCrossRef
29.
Saito S, Sasaki Y, Sakai M. CD4 < sup > +</sup > CD25 < sup > high</sup > regulatory T cells in human pregnancy. J Reprod Immunol. 2005;65(2):111–20.PubMedCrossRef
30.
Santner-Nanan B, Peek MJ, Khanam R, Richarts L, Zhu E, de St Groth BF, et al. Systemic increase in the ratio between Foxp3+ and IL-17-producing CD4+ T cells in healthy pregnancy but not in preeclampsia. J Immunol. 2009;183(11):7023–30.PubMedCrossRef
31.
Dimitriadis E, White C, Jones R, Salamonsen L. Cytokines, Chemokines and growth factors in endometrium related to implantation. Hum Reprod Update. 2005;11(6):613–30.PubMedCrossRef
32.
Jerzak M, Bischof P. Apoptosis in the first trimester human placenta: the role in maintaining immune privilege at the maternal–fetal interface and in the trophoblast remodeling. Eur J Obstet Gynecol Reprod Biol. 2002;100(2):138–42.PubMedCrossRef
33.
W-p Z, Flavell RA. The transcription factor GATA-3 is necessary and sufficient for Th2 cytokine gene expression in CD4 T cells. Cell. 1997;89(4):587–96.CrossRef
34.
Skapenko A, Leipe J, Niesner U, Devriendt K, Beetz R, Radbruch A, et al. GATA-3 in human T cell helper type 2 development. J Exp Med. 2004;199(3):423–8.PubMedCentralPubMedCrossRef
35.
Wallis SK, Cooney LA, Endres JL, Lee MJ, Ryu J, Somers EC, et al. A polymorphism in the interleukin-4 receptor affects the ability of interleukin-4 to regulate Th17 cells: a possible immunoregulatory mechanism for genetic control of the severity of rheumatoid arthritis. Arthritis Res Ther. 2011;13(1):R15.PubMedCentralPubMedCrossRef
Metadaten
Titel
Association of the IL4R single-nucleotide polymorphism I50V with recurrent spontaneous abortion (RSA)
verfasst von
Fataneh Tavasolian
Elham Abdollahi
Morteza Samadi
Publikationsdatum
01.07.2014
Verlag
Springer US
Erschienen in
Journal of Assisted Reproduction and Genetics / Ausgabe 7/2014
Print ISSN: 1058-0468
Elektronische ISSN: 1573-7330
DOI
https://doi.org/10.1007/s10815-014-0234-z

Weitere Artikel der Ausgabe 7/2014

Journal of Assisted Reproduction and Genetics 7/2014 Zur Ausgabe

Genetics

Two different microarray technologies for preimplantation genetic diagnosis and screening, due to reciprocal translocation imbalances, demonstrate equivalent euploidy and clinical pregnancy rates

Commentary

“Been hit twice”: a novel bi-allelic heterozygous mutation in LHCGR

Embryo Biology

Zygote serine decreased uptake from the fertilization medium is associated with implantation and pregnancy

Assisted Reproduction Technologies

Basal serum testosterone levels correlate with ovarian response but do not predict pregnancy outcome in non-PCOS women undergoing IVF

Assisted Reproduction Technologies

The incidence of monozygotic twinning in assisted reproductive technology: Analysis based on results from the 2010 Japanese ART national registry

Assisted Reproduction Technologies

“Mild” vs. “long” protocol for controlled ovarian hyperstimulation in patients with expected poor ovarian responsiveness undergoing in vitro fertilization (IVF): a large prospective randomized trial

Neu im Fachgebiet Gynäkologie und Geburtshilfe

Hirsutismus bei PCOS: Laser- und Lichttherapien helfen

26.04.2024 Hirsutismus Nachrichten

Laser- und Lichtbehandlungen können bei Frauen mit polyzystischem Ovarialsyndrom (PCOS) den übermäßigen Haarwuchs verringern und das Wohlbefinden verbessern – bei alleiniger Anwendung oder in Kombination mit Medikamenten.

ICI-Therapie in der Schwangerschaft wird gut toleriert

23.04.2024 Medikamente in Schwangerschaft und Stillzeit Nachrichten

Müssen sich Schwangere einer Krebstherapie unterziehen, rufen Immuncheckpointinhibitoren offenbar nicht mehr unerwünschte Wirkungen hervor als andere Mittel gegen Krebs.

Weniger postpartale Depressionen nach Esketamin-Einmalgabe

23.04.2024 Depression antepartal oder postpartal Nachrichten

Bislang gibt es kein Medikament zur Prävention von Wochenbettdepressionen. Das Injektionsanästhetikum Esketamin könnte womöglich diese Lücke füllen.

Bei RSV-Impfung vor 60. Lebensjahr über Off-Label-Gebrauch aufklären!

22.04.2024 DGIM 2024 Kongressbericht

Durch die Häufung nach der COVID-19-Pandemie sind Infektionen mit dem Respiratorischen Synzytial-Virus (RSV) in den Fokus gerückt. Fachgesellschaften empfehlen eine Impfung inzwischen nicht nur für Säuglinge und Kleinkinder.

Update Gynäkologie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert – ganz bequem per eMail.

Newsletter bestellen
Bildnachweise