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International Journal of Clinical Oncology

Erschienen in:

16.04.2016 | Original Article

Association of TNFα⁻³⁰⁸, IFNγ⁺⁸⁷⁴, and IL10⁻¹⁰⁸² gene polymorphisms and the risk of non-small cell lung cancer in the population of the South Indian state of Telangana

verfasst von: Vidyullatha Peddireddy, Siva Prasad Badabagni, Shehnaz Sulthana, Venkata Karunakar Kolla, Sandhya Devi Gundimeda, Hemaprasad Mundluru

Erschienen in: International Journal of Clinical Oncology | Ausgabe 5/2016

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Abstract

Background

Cytokine-mediated inflammation is important in the pathogenesis of non-small cell lung cancer (NSCLC). Genetic polymorphisms in cytokine genes and their association with lung cancer in the Indian population have not been reported.

Methods

For the first time, we analyzed genetic polymorphisms of TNFα ⁻³⁰⁸, IFNγ ⁺⁸⁷⁴, and IL10 ⁻¹⁰⁸² genes in 246 NSCLC patients and 250 healthy controls in the South Indian population from Telangana using ARMS PCR.

Results

IFNγ⁺⁸⁷⁴ A/T and IL10⁻¹⁰⁸² G/G gene polymorphisms were found to be significantly associated with NSCLC with 1.56- and 1.68-fold disease risk, respectively. There was no association between the risk of NSCLC and TNFα⁻³⁰⁸ polymorphism. Gene polymorphisms stratified according to smoking revealed that IFNγ⁺⁸⁷⁴ A/T polymorphisms in smokers increased the disease risk by 2.91 fold. IL10⁻¹⁰⁸² G/G polymorphisms showed 2-fold increased risk among patients who were smokers when compared to the controls. However, there was no association between TNFα⁻³⁰⁸, IFNγ⁺⁸⁷⁴, and IL10⁻¹⁰⁸² gene polymorphism and the stage of the NSCLC patients. The overall risk associated with the combination of these polymorphisms indicated that the TNFα⁻³⁰⁸ G/A + IFNγ⁺⁸⁷⁴ A/T + IL10⁻¹⁰⁸² G/G genotype increased the risk by 1.5 fold.

Conclusions

The results of our study indicate an association between cytokine gene polymorphisms and the risk of NSCLC in an Indian population.

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Titel: Association of TNFα−308, IFNγ+874, and IL10−1082 gene polymorphisms and the risk of non-small cell lung cancer in the population of the South Indian state of Telangana
verfasst von: Vidyullatha Peddireddy
Siva Prasad Badabagni
Shehnaz Sulthana
Venkata Karunakar Kolla
Sandhya Devi Gundimeda
Hemaprasad Mundluru
Publikationsdatum: 16.04.2016
Verlag: Springer Japan
Erschienen in: International Journal of Clinical Oncology / Ausgabe 5/2016
Print ISSN: 1341-9625
Elektronische ISSN: 1437-7772
DOI: https://doi.org/10.1007/s10147-016-0972-2

Springer Medizin

Association of TNFα⁻³⁰⁸, IFNγ⁺⁸⁷⁴, and IL10⁻¹⁰⁸² gene polymorphisms and the risk of non-small cell lung cancer in the population of the South Indian state of Telangana