nach oben

Erschienen in:

01.09.2011 | Article

Associations between single-nucleotide polymorphisms (+45T>G, +276G>T, −11377C>G, −11391G>A) of adiponectin gene and type 2 diabetes mellitus: a systematic review and meta-analysis

verfasst von: L. Y. Han, Q. H. Wu, M. L. Jiao, Y. H. Hao, L. B. Liang, L. J. Gao, D. G. Legge, H. Quan, M. M. Zhao, N. Ning, Z. Kang, H. Sun

Erschienen in: Diabetologia | Ausgabe 9/2011

Einloggen, um Zugang zu erhalten

Abstract

Aims/hypothesis

The associations between adiponectin polymorphisms and type 2 diabetes have been studied widely; however, results are inconsistent.

Methods

We searched electronic literature databases and reference lists of relevant articles. A fixed or random effects model was used on the basis of heterogeneity. Sub-group and meta-regression analyses were conducted to explore the sources of heterogeneity.

Results

There were no statistically significant associations between +45T>G (rs2241766), +276G>T (rs1501299), −11391G>A (rs17300539) and type 2 diabetes risk. However, for −11377C>G (rs266729), the pooled OR (95% CI) for G vs C allele was 1.07 (1.03–1.11, p = 0.001). Subgroup analysis by study design revealed that −11377C>G (rs266729) dominant model (CG+GG vs CC, p = 0.0008) and G vs C allele (p = 0.0004) might be associated with type 2 diabetes risk in population-based case–control studies. After stratification by ethnicity, we found that −11377C>G (rs266729) dominant model (CG+GG vs CC, p = 0.004) and G vs C allele (p = 0.001) might be associated with type 2 diabetes risk in white individuals. In individuals with a family history of diabetes, the presence of −11391G>A (rs17300539) dominant model (GA+AA vs GG) and A vs G allele might be associated with increased risk of type 2 diabetes.

Conclusions/interpretation

The presence of +45T>G (rs2241766), +276G>T (rs1501299) and −11391G>A (rs17300539) do not appear to influence the development of type 2 diabetes. However, G vs C allele of −11377C>G (rs266729) might be a risk factor for type 2 diabetes.

Nur mit Berechtigung zugänglich

King H, Aubert RE, Herman WH (1998) Global burden of diabetes, 1995–2025: prevalence, numerical estimates, and projections. Diabetes Care 21:1414–1431PubMedCrossRef

Wild S, Roglic G, Green A, Sicree R, King H (2004) Global prevalence of diabetes: estimates for the year 2000 and projections for 2030. Diabetes Care 27:1047–1053PubMedCrossRef

Stumvoll M, Goldstein BJ, van Haeften TW (2005) Type 2 diabetes: principles of pathogenesis and therapy. Lancet 365:1333–1346PubMedCrossRef

Kershaw EE, Flier JS (2004) Adipose tissue as an endocrine organ. J Clin Endocrinol Metab 89:2548–2556PubMedCrossRef

Vionnet N, Hani EH, Dupont S et al (2000) Genomewide search for type 2 diabetes-susceptibility genes in French whites: evidence for a novel susceptibility locus for early-onset diabetes on chromosome 3q27-qter and independent replication of a type 2-diabetes locus on chromosome 1q21-q24. Am J Hum Genet 67:1470–1480PubMedCrossRef

Kissebah AH, Sonnenberg GE, Myklebust J et al (2000) Quantitative trait loci on chromosomes 3 and 17 influence phenotypes of the metabolic syndrome. Proc Natl Acad Sci USA 97:14478–14483PubMedCrossRef

Yamauchi T, Kamon J, Waki H et al (2001) The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity. Nat Med 7:941–946PubMedCrossRef

Scherer PE (2006) Adipose tissue: from lipid storage compartment to endocrine organ. Diabetes 55:1537–1545PubMedCrossRef

Hotta K, Funahashi T, Bodkin NL et al (2001) Circulating concentrations of the adipocyte protein adiponectin are decreased in parallel with reduced insulin sensitivity during the progression to type 2 diabetes in rhesus monkeys. Diabetes 50:1126–1133PubMedCrossRef

10.

Berg AH, Combs TP, Scherer PE (2002) ACRP30/adiponectin: an adipokine regulating glucose and lipid metabolism. Trends Endocrinol Metab 13:84–89PubMedCrossRef

11.

Yamauchi T, Oike Y, Kamon J et al (2002) Increased insulin sensitivity despite lipodystrophy in Crebbp heterozygous mice. Nat Genet 30:221–226PubMedCrossRef

12.

Hotta K, Funahashi T, Arita Y et al (2000) Plasma concentrations of a novel, adipose-specific protein, adiponectin, in type 2 diabetic patients. Arterioscler Thromb Vasc Biol 20:1595–1599PubMedCrossRef

13.

Daimon M, Oizumi T, Saitoh T et al (2003) Decreased serum levels of adiponectin are a risk factor for the progression to type 2 diabetes in the Japanese population: the Funagata Study. Diabetes Care 26:2015–2020PubMedCrossRef

14.

Lindsay RS, Funahashi T, Hanson RL et al (2002) Adiponectin and development of type 2 diabetes in the Pima Indian population. Lancet 360:57–58PubMedCrossRef

15.

Ling H, Waterworth DM, Stirnadel HA et al (2009) Genome-wide linkage and association analyses to identify genes influencing adiponectin levels: the GEMS Study. Obesity (Silver Spring) 17:737–744CrossRef

16.

Heid IM, Henneman P, Hicks A et al (2010) Clear detection of ADIPOQ locus as the major gene for plasma adiponectin: results of genome-wide association analyses including 4659 European individuals. Atherosclerosis 208:412–420PubMedCrossRef

17.

Richards JB, Waterworth D, O'Rahilly S et al (2009) A genome-wide association study reveals variants in ARL15 that influence adiponectin levels. PLoS Genet 5:e1000768PubMedCrossRef

18.

Jee SH, Sull JW, Lee JE et al (2010) Adiponectin concentrations: a genome-wide association study. Am J Hum Genet 87:545–552PubMedCrossRef

19.

Vasseur F, Helbecque N, Dina C et al (2002) Single-nucleotide polymorphism haplotypes in the both proximal promoter and exon 3 of the APM1 gene modulate adipocyte-secreted adiponectin hormone levels and contribute to the genetic risk for type 2 diabetes in French Caucasians. Hum Mol Genet 11:2607–2614PubMedCrossRef

20.

Gonzalez-Sanchez JL, Zabena CA, Martinez-Larrad MT et al (2005) An SNP in the adiponectin gene is associated with decreased serum adiponectin levels and risk for impaired glucose tolerance. Obes Res 13:807–812PubMedCrossRef

21.

Menzaghi C, Trischitta V, Doria A (2007) Genetic influences of adiponectin on insulin resistance, type 2 diabetes, and cardiovascular disease. Diabetes 56:1198–1209PubMedCrossRef

22.

Comuzzie AG, Funahashi T, Sonnenberg G et al (2001) The genetic basis of plasma variation in adiponectin, a global endophenotype for obesity and the metabolic syndrome. J Clin Endocrinol Metab 86:4321–4325PubMedCrossRef

23.

Wolfs MG, Hofker MH, Wijmenga C, van Haeften TW (2009) Type 2 diabetes mellitus: new genetic insights will lead to new therapeutics. Curr Genomics 10:110–118PubMedCrossRef

24.

Gable DR, Hurel SJ, Humphries SE (2006) Adiponectin and its gene variants as risk factors for insulin resistance, the metabolic syndrome and cardiovascular disease. Atherosclerosis 188:231–244PubMedCrossRef

25.

Hara K, Boutin P, Mori Y et al (2002) Genetic variation in the gene encoding adiponectin is associated with an increased risk of type 2 diabetes in the Japanese population. Diabetes 51:536–540PubMedCrossRef

26.

Menzaghi C, Ercolino T, Di PR et al (2002) A haplotype at the adiponectin locus is associated with obesity and other features of the insulin resistance syndrome. Diabetes 51:2306–2312PubMedCrossRef

27.

Lee YY, Lee NS, Cho YM et al (2005) Genetic association study of adiponectin polymorphisms with risk of type 2 diabetes mellitus in Korean population. Diabet Med 22:569–575PubMedCrossRef

28.

Ukkola O, Santaniemi M, Rankinen T et al (2005) Adiponectin polymorphisms, adiposity and insulin metabolism: HERITAGE family study and Oulu diabetic study. Ann Med 37:141–150PubMedCrossRef

29.

Li LL, Kang XL, Ran XJ et al (2007) Associations between 45T/G polymorphism of the adiponectin gene and plasma adiponectin levels with type 2 diabetes. Clin Exp Pharmacol Physiol 34:1287–1290PubMedCrossRef

30.

Yamaguchi S, Yamada Y, Matsuo H et al (2007) Gender differences in the association of gene polymorphisms with type 2 diabetes mellitus. Int J Mol Med 19:631–637PubMed

31.

Potapov VA, Chistiakov DA, Dubinina A, Shamkhalova MS, Shestakova MV, Nosikov VV (2008) Adiponectin and adiponectin receptor gene variants in relation to type 2 diabetes and insulin resistance-related phenotypes. Rev Diabet Stud 5:28–37PubMedCrossRef

32.

Mohammadzadeh G, Zarghami N (2009) Associations between single-nucleotide polymorphisms of the adiponectin gene, serum adiponectin levels and increased risk of type 2 diabetes mellitus in Iranian obese individuals. Scand J Clin Lab Invest 69:764–771PubMedCrossRef

33.

Sun H, Gong ZC, Yin JY et al (2008) The association of adiponectin allele 45T/G and −11377C/G polymorphisms with type 2 diabetes and rosiglitazone response in Chinese patients. Br J Clin Pharmacol 65:917–926PubMedCrossRef

34.

Wang X, Zhang S, Chen Y et al (2009) APM1 gene variants −11377C/G and 4545G/C are associated respectively with obesity and with non-obesity in Chinese type 2 diabetes. Diabetes Res Clin Pract 84:205–210PubMedCrossRef

35.

Suriyaprom K, Phonrat B, Namjuntra P, Harnroongroj T, Tungtrongchitr R (2010) The −11377C>G adiponectin gene polymorphism alters the adiponectin concentration and the susceptibility to type 2 diabetes in Thais. Int J Vitam Nutr Res 80:216–224PubMedCrossRef

36.

Populaire C, Mori Y, Dina C et al (2003) Does the −11377 promoter variant of APM1 gene contribute to the genetic risk for type 2 diabetes mellitus in Japanese families. Diabetologia 46:443–445PubMed

37.

Gu HF, Abulaiti A, Ostenson CG et al (2004) Single nucleotide polymorphisms in the proximal promoter region of the adiponectin (APM1) gene are associated with type 2 diabetes in Swedish caucasians. Diabetes 53(Suppl 1):S31–S35PubMedCrossRef

38.

Vasseur F, Helbecque N, Lobbens S et al (2005) Hypoadiponectinaemia and high risk of type 2 diabetes are associated with adiponectin-encoding (ACDC) gene promoter variants in morbid obesity: evidence for a role of ACDC in diabesity. Diabetologia 48:892–899PubMedCrossRef

39.

Yang WS, Yang YC, Chen CL et al (2007) Adiponectin SNP276 is associated with obesity, the metabolic syndrome, and diabetes in the elderly. Am J Clin Nutr 86:509–513PubMed

40.

Magdalena S, Malgorzata M, Beata W et al (2009) Variants of the adiponectin gene and type 2 diabetes in a Polish population. Acta Diabetol 46:317–322CrossRef

41.

Wang Y, Zhang D, Liu Y et al (2009) Association study of the single nucleotide polymorphisms in adiponectin-associated genes with type 2 diabetes in Han Chinese. J Genet Genomics 36:417–423PubMedCrossRef

42.

Yang M, Qiu CC, Chen W, Xu LL, Yu M, Xiang HD (2008) Identification of a regulatory single nucleotide polymorphism in the adiponectin (APM1) gene associated with type 2 diabetes in Han nationality. Biomed Environ Sci 21:454–459PubMedCrossRef

43.

Vendramini MF, Pereira AC, Ferreira SR, Kasamatsu TS, Moises RS (2010) Association of genetic variants in the adiponectin encoding gene (ADIPOQ) with type 2 diabetes in Japanese Brazilians. J Diabetes Complications 24:115–120PubMedCrossRef

44.

Gibson F, Froguel P (2004) Genetics of the APM1 locus and its contribution to type 2 diabetes susceptibility in French Caucasians. Diabetes 53:2977–2983PubMedCrossRef

45.

Hu FB, Doria A, Li T et al (2004) Genetic variation at the adiponectin locus and risk of type 2 diabetes in women. Diabetes 53:209–213PubMedCrossRef

46.

Fumeron F, Aubert R, Siddiq A et al (2004) Adiponectin gene polymorphisms and adiponectin levels are independently associated with the development of hyperglycemia during a 3-year period: the epidemiologic data on the insulin resistance syndrome prospective study. Diabetes 53:1150–1157PubMedCrossRef

47.

de Courten BV, Hanson RL, Funahashi T et al (2005) Common polymorphisms in the adiponectin gene ACDC are not associated with diabetes in Pima Indians. Diabetes 54:284–289CrossRef

48.

Tso AW, Sham PC, Wat NM et al (2006) Polymorphisms of the gene encoding adiponectin and glycaemic outcome of Chinese subjects with impaired glucose tolerance: a 5-year follow-up study. Diabetologia 49:1806–1815PubMedCrossRef

49.

Nannipieri M, Posadas R, Bonotti A et al (2006) Polymorphism of the 3′-untranslated region of the leptin receptor gene, but not the adiponectin SNP45 polymorphism, predicts type 2 diabetes: a population-based study. Diabetes Care 29:2509–2511PubMedCrossRef

50.

Schwarz PE, Govindarajalu S, Towers W et al (2006) Haplotypes in the promoter region of the ADIPOQ gene are associated with increased diabetes risk in a German Caucasian population. Horm Metab Res 38:447–451PubMedCrossRef

51.

Gable DR, Matin J, Whittall R et al (2007) Common adiponectin gene variants show different effects on risk of cardiovascular disease and type 2 diabetes in European subjects. Ann Hum Genet 71:453–466PubMedCrossRef

52.

Olckers A, Towers GW, der Merwe Av, Schwarz PE, Rheeder P, Schutte AE (2007) Protective effect against type 2 diabetes mellitus identified within the ACDC gene in a black South African diabetic cohort. Metabolism 56:587–592PubMedCrossRef

53.

Jaziri R, Lobbens S, Aubert R et al (2006) The PPARG Pro12Ala polymorphism is associated with a decreased risk of developing hyperglycemia over 6 years and combines with the effect of the APM1 G-11391A single nucleotide polymorphism: the Data From an Epidemiological Study on the Insulin Resistance Syndrome (DESIR) Study. Diabetes 55:1157–1162PubMedCrossRef

54.

Chiodini BD, Specchia C, Gori F et al (2010) Adiponectin gene polymorphisms and their effect on the risk of myocardial infarction and type 2 diabetes: an association study in an Italian population. Ther Adv Cardiovasc Dis 4:223–230PubMedCrossRef

55.

Hivert MF, Manning AK, McAteer JB et al (2008) Common variants in the adiponectin gene (ADIPOQ) associated with plasma adiponectin levels, type 2 diabetes, and diabetes-related quantitative traits: the Framingham Offspring Study. Diabetes 57:3353–3359PubMedCrossRef

56.

Staiger H, Machicao F, Fritsche A, Haring HU (2009) Pathomechanisms of type 2 diabetes genes. Endocr Rev 30:557–585PubMedCrossRef

57.

Lichtenstein MJ, Mulrow CD, Elwood PC (1987) Guidelines for reading case–control studies. J Chronic Dis 40:893–903PubMedCrossRef

58.

Thakkinstian A, McEvoy M, Minelli C et al (2005) Systematic review and meta-analysis of the association between β2-adrenoceptor polymorphisms and asthma: a HuGE review. Am J Epidemiol 162:201–211PubMedCrossRef

59.

Attia J, Thakkinstian A, D’Este C (2003) Meta-analyses of molecular association studies: methodologic lessons for genetic epidemiology. J Clin Epidemiol 56:297–303PubMedCrossRef

60.

Higgins JP, Thompson SG (2002) Quantifying heterogeneity in a meta-analysis. Stat Med 21:1539–1558PubMedCrossRef

61.

DerSimonian R, Laird N (1986) Meta-analysis in clinical trials. Control Clin Trials 7:177–188PubMedCrossRef

62.

Morgan JF (2007) p Value fetishism and use of the Bonferroni adjustment. Evid Based Ment Health 10:34–35PubMedCrossRef

63.

Egger M, Davey SG, Schneider M, Minder C (1997) Bias in meta-analysis detected by a simple, graphical test. BMJ 315:629–634PubMed

64.

Duval S, Tweedie R (2000) Trim and fill: a simple funnel-plot-based method of testing and adjusting for publication bias in meta-analysis. Biometrics 56:455–463PubMedCrossRef

65.

Voight BF, Scott LJ, Steinthorsdottir V et al (2010) Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis. Nat Genet 42:579–589PubMedCrossRef

66.

Gong M, Long J, Liu Q, Deng HC (2010) Association of the ADIPOQ rs17360539 and rs266729 polymorphisms with type 2 diabetes: a meta-analysis. Mol Cell Endocrinol 325:78–83PubMedCrossRef

67.

Stumvoll M, Tschritter O, Fritsche A et al (2002) Association of the T-G polymorphism in adiponectin (exon 2) with obesity and insulin sensitivity: interaction with family history of type 2 diabetes. Diabetes 51:37–41PubMedCrossRef

68.

Stenvinkel P, Marchlewska A, Pecoits-Filho R et al (2004) Adiponectin in renal disease: relationship to phenotype and genetic variation in the gene encoding adiponectin. Kidney Int 65:274–281PubMedCrossRef

69.

Li S, Li L, Li K et al (2008) Association of adipose most abundant transcript 1 gene (apM1) with type 2 diabetes mellitus in a Chinese population: a meta-analysis of case–control studies. Clin Endocrinol (Oxf) 68:885–889CrossRef

70.

Zeggini E, Ioannidis JP (2009) Meta-analysis in genome-wide association studies. Pharmacogenomics 10:191–201PubMedCrossRef

71.

Matsuzawa Y (2005) Adiponectin: identification, physiology and clinical relevance in metabolic and vascular disease. Atheroscler Suppl 6:7–14PubMedCrossRef

72.

Koerner A, Kratzsch J, Kiess W (2005) Adipocytokines: leptin—the classical, resistin—the controversical, adiponectin—the promising, and more to come. Best Pract Res Clin Endocrinol Metab 19:525–546PubMedCrossRef

Titel: Associations between single-nucleotide polymorphisms (+45T>G, +276G>T, −11377C>G, −11391G>A) of adiponectin gene and type 2 diabetes mellitus: a systematic review and meta-analysis
verfasst von: L. Y. Han
Q. H. Wu
M. L. Jiao
Y. H. Hao
L. B. Liang
L. J. Gao
D. G. Legge
H. Quan
M. M. Zhao
N. Ning
Z. Kang
H. Sun
Publikationsdatum: 01.09.2011
Verlag: Springer-Verlag
Erschienen in: Diabetologia / Ausgabe 9/2011
Print ISSN: 0012-186X
Elektronische ISSN: 1432-0428
DOI: https://doi.org/10.1007/s00125-011-2202-9

Leitlinien kompakt für die Innere Medizin

Mit medbee Pocketcards sicher entscheiden.

^{Seit 2022 gehört die medbee GmbH zum Springer Medizin Verlag}

Kostenlos registrieren

Neu im Fachgebiet Innere Medizin

Notfall-TEP der Hüfte ist auch bei 90-Jährigen machbar

26.04.2024 Hüft-TEP Nachrichten

Ob bei einer Notfalloperation nach Schenkelhalsfraktur eine Hemiarthroplastik oder eine totale Endoprothese (TEP) eingebaut wird, sollte nicht allein vom Alter der Patientinnen und Patienten abhängen. Auch über 90-Jährige können von der TEP profitieren.

Niedriger diastolischer Blutdruck erhöht Risiko für schwere kardiovaskuläre Komplikationen

25.04.2024 Hypotonie Nachrichten

Wenn unter einer medikamentösen Hochdrucktherapie der diastolische Blutdruck in den Keller geht, steigt das Risiko für schwere kardiovaskuläre Ereignisse: Darauf deutet eine Sekundäranalyse der SPRINT-Studie hin.

Bei schweren Reaktionen auf Insektenstiche empfiehlt sich eine spezifische Immuntherapie

25.04.2024 Allergien und Intoleranzreaktionen Nachrichten

Insektenstiche sind bei Erwachsenen die häufigsten Auslöser einer Anaphylaxie. Einen wirksamen Schutz vor schweren anaphylaktischen Reaktionen bietet die allergenspezifische Immuntherapie. Jedoch kommt sie noch viel zu selten zum Einsatz.

Therapiestart mit Blutdrucksenkern erhöht Frakturrisiko

25.04.2024 Hypertonie Nachrichten

Beginnen ältere Männer im Pflegeheim eine Antihypertensiva-Therapie, dann ist die Frakturrate in den folgenden 30 Tagen mehr als verdoppelt. Besonders häufig stürzen Demenzkranke und Männer, die erstmals Blutdrucksenker nehmen. Dafür spricht eine Analyse unter US-Veteranen.

Update Innere Medizin

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.

Newsletter bestellen

Springer Medizin

Abstract

Aims/hypothesis

Methods

Results

Conclusions/interpretation

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

Weitere Artikel der Ausgabe 9/2011

New approaches for the evaluation of renal vascular function in diabetes

Common variants in CNDP1 and CNDP2, and risk of nephropathy in type 2 diabetes

Chronic treatment with a glucagon receptor antagonist lowers glucose and moderately raises circulating glucagon and glucagon-like peptide 1 without severe alpha cell hypertrophy in diet-induced obese mice

Plasma procalcitonin and risk of type 2 diabetes in the general population

Glycated albumin but not HbA1c reflects glycaemic control in patients with neonatal diabetes mellitus