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Journal of Interventional Cardiac Electrophysiology

Erschienen in:

01.12.2012

Atrial conduction time and atrial mechanical function in patients with impaired fasting glucose

verfasst von: Selim Ayhan, Serkan Ozturk, Aytekin Alcelik, Mehmet Fatih Ozlu, Alim Erdem, Tolga Memioglu, Mesut Ozdemir, Mehmet Yazici

Erschienen in: Journal of Interventional Cardiac Electrophysiology | Ausgabe 3/2012

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Abstract

Background

Prolonging atrial conduction time, as measured by tissue Doppler imaging (TDI), is an independent predictor of new onset or recurrent atrial fibrillation (AF). We investigated atrial conduction time and cardiac mechanical function in patients with impaired fasting glucose (IFG) using echocardiography.

Methods

Thirty patients with IFG (19 males and 11 females; age, 46.9 ± 9.5 years) and 30 control subjects (18 males and 12 females; age, 46.7 ± 8.2 years) were included. Atrial conduction time was determined from the lateral mitral annulus (PA lateral), septal mitral annulus (PA septal), and lateral tricuspid annulus (PA tricuspid) by TDI. Inter- and intra-atrial electromechanical delays (EMDs) were calculated. Left atrial (LA) volumes were determined according to the biplane area–length method. LA mechanical function parameters were calculated.

Results

LA passive emptying volume and LA passive emptying fraction decreased significantly in patients with IFG as compared with control subjects (p < 0.001 and p < 0.001, respectively). PA lateral and PA septal durations were significantly higher in patients with IFG than in the control group. However, no difference in PA tricuspid duration was observed between the two groups. Inter- and intra-atrial EMDs were significantly higher in patients with IFG as compared with the control subjects (median [interquartile range], 34.0 [17.0] vs. 17.0 [4.0], p < 0.001 and 15.0 [8.5] vs. 7.5 [2.0], p < 0.001, respectively). Positive correlations were detected between both inter- and intra-atrial EMD and glucose levels (r = 0.76, p < 0.001 and r = 0.68, p < 0.001, respectively). Additionally, a multiple linear regression analysis revealed that glucose levels were independently associated with inter-atrial EMD (β = 0.753, p < 0.001).

Conclusion

We showed that IFG was associated with inter- and intra-atrial EMD. Our findings suggest that IFG is an etiological factor for the development of AF.

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Titel: Atrial conduction time and atrial mechanical function in patients with impaired fasting glucose
verfasst von: Selim Ayhan
Serkan Ozturk
Aytekin Alcelik
Mehmet Fatih Ozlu
Alim Erdem
Tolga Memioglu
Mesut Ozdemir
Mehmet Yazici
Publikationsdatum: 01.12.2012
Verlag: Springer US
Erschienen in: Journal of Interventional Cardiac Electrophysiology / Ausgabe 3/2012
Print ISSN: 1383-875X
Elektronische ISSN: 1572-8595
DOI: https://doi.org/10.1007/s10840-012-9722-1

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Atrial conduction time and atrial mechanical function in patients with impaired fasting glucose