nach oben

Acta Neurochirurgica

Erschienen in:

01.10.2009 | Clinical Article

Atypical speech activations: PET results of 92 patients with left-hemispheric epilepsy

verfasst von: Taner Tanriverdi, Denise Klein, Kelvin Mok, Sylvain Milot, Jasem Al-Hashel, Nicole Poulin, Andre Olivier

Erschienen in: Acta Neurochirurgica | Ausgabe 10/2009

Einloggen, um Zugang zu erhalten

Abstract

Purpose

Language lateralization and factors that may influence language lateralization were investigated using positron emission tomography.

Methods

Ninety-two right-handed patients who had left-sided lesions (tumors, focal cortical dysplasia, and vascular lesions) and 19 right-handed normal subjects were included and synonym generation task was used for evaluation of language lateralization.

Results

As expected, the majority of individuals in both groups showed left hemisphere dominance. Lesions in the vicinity of language-related areas did not alter patterns of activation responses. However, atypical inferior frontal gyrus (IFG) activations (33.6%) were more commonly observed in the patient group than in the control group (21%). There were no clear right-sided IFG activations in the control group but almost 28% of the patients showed clear right-sided IFG activations. Atypical language lateralization was strongly correlated with duration of seizure (p = 0.01) and early age at onset (p = 0.03).

Conclusions

Our data provide evidence for inter-hemispheric plasticity related to language function as a response to lesions involving the left hemisphere. A better understanding of the dynamic organization of the brain and about the interaction between the lesion and reactional plasticity will lead to changes in surgical strategy, which will enable us to perform a total removal of the lesion involving eloquent brain areas with improved functional outcome.

Adcock JE, Wise RG, Oxbury JM, Oxbury SM, Metthews PM (2003) Quantitative fMRI assessment of the differences in lateralization of language-related brain activation in patients with temporal lobe epilepsy. Neuroimage 18:423–438. doi:10.1016/S1053-8119(02)00013-7 CrossRefPubMed

Anderson DP, Harvey S, Saling MM, Anderson V, Kean M, Abbott DF, Wellard RM, Jackson GD (2006) fMRI lateralization of expressive language in children with cerebral lesions. Epilepsia 47:998–1008. doi:10.1111/j.1528-1167.2006.00572.x CrossRefPubMed

Bavelier D, Neville HJ (2002) Cross-modal plasticity: where and how? Nat Rev Neurosci 3:443–452PubMed

Beck E (1950) The origin, course and termination of the prefrontopontine tract in the human brain. Brain 73:368–391. doi:10.1093/brain/73.3.368 CrossRefPubMed

Benson DF (1985) Language in the left hemisphere. In: Benson DF, Zaidel E (eds) The dual brain. Guilford, New York, pp 193–203

Broca P (1861) Remarques sur le siege de la faculte du langage articule, suives d’une observation d’aphemie (perte de la parole). Bull Soc Anatomique 6:330–357

Buchel C, Price C, Frackowiak RS, Friston K (1998) Different activation patterns in the visual cortex of late and congenitally blind subjects. Brain 121:409–419. doi:10.1093/brain/121.3.409 CrossRefPubMed

Byrne JH (1997) Synapses. Plastic plasticity. Nature 389:791–792. doi:10.1038/39746 CrossRefPubMed

Collins DL, Zijdenbas AP, Kollokian V, Sled JG, Kabani NJ, Holmes CJ et al (1998) Desing and construction of a realistic digital brain phantom. IEEE Trans Med Imaging 17:463–468. doi:10.1109/42.712135 CrossRefPubMed

10.

Collins L, Neelin P, Peters TM, Evans AC (1994) Automatic 3D intersubject registration of MR volumetric data in standardized Talairac space. J Comput Assist Tomogr 18:192–205. doi:10.1097/00004728-199403000-00005 CrossRefPubMed

11.

Dityatev A, Schachner M (2003) Extracellular matrix molecules and synaptic plasticity. Nat Rev Neurosci 4:456–468. doi:10.1038/nrn1115 CrossRefPubMed

12.

Duffau H (2005) Lessons from brain mapping in surgery for low-grade gliomas: insights into associations between tumour and brain plasticity. Lancet Neurol 4:476–486. doi:10.1016/S1474-4422(05)70140-X CrossRefPubMed

13.

Duffau H (2006) Brain plasticity: from pathophysiological mechanisms to therapeutic applications. J Clin Neurosci 13:885–897. doi:10.1016/j.jocn.2005.11.045 CrossRefPubMed

14.

Duffau H (2006) New concepts in surgery of WHO grade II gliomas: functional brain mapping, connectionism and plasticity—a review. J Neurooncol 79:77–115. doi:10.1007/s11060-005-9109-6 CrossRefPubMed

15.

Duffau H (2007) Contribution of cortical and subcortical electrostimulation in brain gliomas surgery: Methodological and functional considerations. Clin Neurophysiol 37:373–382. doi:10.1016/j.neucli.2007.09.003 CrossRef

16.

Duffau H (2008) Brain plasticity and tumors. Adv Tech Stand Neurosurg 33:3–33. doi:10.1007/978-3-211-72283-1_1 CrossRefPubMed

17.

Duffau H, Capelle L, Denvil D, Sichez N, Gatignol P, Lopes M, Mitchell MC, Sichez JP, Van Effenterre R (2003) Functional recovery after surgical resection of low grade gliomas in eloquent brain: hypothesis of brain compensation. J Neurol Neurosurg Psychiatry 74:901–907. doi:10.1136/jnnp.74.7.901 CrossRefPubMed

18.

Duffau H, Denvil D, Capelle L (2002) Long term reshaping of language, sensory and motor maps after gliomas resection: a new parameter to integrate in the surgical strategy. J Neurol Neurosurg Psychiatry 72:511–516PubMed

19.

Duffau H, Sichez JP, Lehericy S (2000) Intraoperative unmasking of brain redundant motor sites during resection of a precentral angioma. Evidence using direct cortical stimulations. Ann Neurol 47:132–135. doi:10.1002/1531-8249(200001)47:1<132::AID-ANA23>3.0.CO;2-0 CrossRefPubMed

20.

Duffau H, Taillandier L, Gatignol P, Capelle L (2006) The insular lobe and brain plasticity: Lessons from tumor surgery. Clin Neurol Neurosurg 108:543–548. doi:10.1016/j.clineuro.2005.09.004 CrossRefPubMed

21.

Evans AC, Marrett S, Neelin P, Collins L, Worsley K, Dai W, Milot S et al (1992) Anatomical mapping of functional activation in stereotactic coordinate space. Neuroimage 1:43–53. doi:10.1016/1053-8119(92)90006-9 CrossRefPubMed

22.

Evans AC, Marrett S, Torrescorzo J, Ku S, Collins L (1991) MRI-PET correlation in three dimensions using a volume-of-interest (VOI) atlas. J Cereb Blood Flow Metab 11:A69–A78PubMed

23.

Evans AC, Thompson CJ, Marrett S, Meyer E, Mazza M (1991) Performance evaluation of the PC-2048: a new 15-slice encoded-crystal PET scanner for neurological studies. IEEE Trans Med Imaging 10:90–98. doi:10.1109/42.75615 CrossRefPubMed

24.

Fields RD, Stevens-Graham B (2002) New insights into neuron-glia communication. Science 298:556–562. doi:10.1126/science.298.5593.556 CrossRefPubMed

25.

Gross CG (2000) Neurogenesis in the adult brain: death of a dogma. Nat Rev Neurosci 1:67–73. doi:10.1038/35036235 CrossRefPubMed

26.

Helmstaedter C, Kurthern LDB, Elger CE (1997) Patterns of language dominance in focal left and right hemisphere epilepsies: Relation to MRI findings, EEG, sex, and age at onset of epilepsy. Brain Cogn 33:135–150. doi:10.1006/brcg.1997.0888 CrossRefPubMed

27.

Holodny AI, Schulder M, Ybasco A, Liu WC (2002) Translocation of Broca, s area to the contralateral hemisphere as the result of the growth of a left inferior frontal gliomas. J Comput Assist Tomogr 26:941–943. doi:10.1097/00004728-200211000-00014 CrossRefPubMed

28.

Jacobs KM, Donoghue JP (1991) Reshaping the cortical motor map by unmasking latent intracortical connections. Science 251:944–947. doi:10.1126/science.2000496 CrossRefPubMed

29.

Junck L, Gilman S, Rothley JR, Betley AT, Koeppe RA, Hichwa RD (1998) A relationship between metabolism in frontal lobes and cerebellum in normal subjects studied with PET. J Cereb Blood Flow Metab 8:774–782

30.

Karbe H, Herholz K, Halber M, Heiss WD (1988) Collateral inhibition of transcallosal activity facilitates functional brain asymmetry. J Cereb Blood Flow Metab 18:1157–1161. doi:10.1097/00004647-199810000-00012 CrossRef

31.

Karbe H, Thiel A, Weber-Luxenburger G, Herholz K, Kessler J, Heiss WD (1998) Brain plasticity in poststroke aphasia: what is the contribution of the right hemisphere? Brain Lang 64:215–230. doi:10.1006/brln.1998.1961 CrossRefPubMed

32.

Klein D, Olivier A, Milner B, Zatorre RJ, Johnsrude I, Meyer E, Evans AC (1997) Obligatory role of the LIFG in synonym generation: evidence from PET and cortical stimulation. Neuroreport 8:3275–3279. doi:10.1097/00001756-199710200-00017 CrossRefPubMed

33.

Klein D, Watkins KE, Zatorre RJ, Milner B (2006) Word and nonword repetition in bilingual subjects: a PET study. Hum Brain Mapp 27:153–161. doi:10.1002/hbm.20174 CrossRefPubMed

34.

Klein D, Zatorre RJ, Milner B, Meyer E, Evans C (1994) Left putaminal activation when speaking a second language: evidence from PET. Neuroreport 5:2295–2297. doi:10.1097/00001756-199411000-00022 CrossRefPubMed

35.

Laubach M, Wessberg J, Nicolelis MA (2000) Cortical ensemble activity increasingly predicts behaviour outcomes during learning of a motor task. Nature 405:567–571. doi:10.1038/35014604 CrossRefPubMed

36.

Lazar RM, Marshall RS, Pile-Spellman J, Duong HC, Mohr JP, Young WL et al (2000) Interhemispheric transfer of language in patients with left frontal cerebral arteriovenous malformation. Neuropsychologia 38:1325–1332. doi:10.1016/S0028-3932(00)00054-3 CrossRefPubMed

37.

Levanen S, Jousmaki V, Hari R (1998) Vibration-induced auditory-cortex activation in a congenitally deaf adult. Curr Biol 8:869–872. doi:10.1016/S0960-9822(07) 00348-X CrossRefPubMed

38.

Liegeois F, Connelly A, Cross JH, Boyd SG, Gadian DG, Vargha-Khadem F, Baldeweg T (2004) Language reorganization in children with early-onset lesions of the left hemisphere: an fMRI study. Brain 127:1229–1236. doi:10.1093/brain/awh159 CrossRefPubMed

39.

Mazoyer-Tzourio N, Josse G, Crivello F, Mazoyer B (2004) Interindividual variability in the hemispheric organization for speech. Neuroimage 21:422–435. doi:10.1016/j.neuroimage.2003.08.032 CrossRef

40.

Muller RA, Behen ME, Rothermel RD, Muzik O, Chakraborty PK, Chugani HT (1999) Brain organization for language in children, adolescents, and adults with left hemisphere lesion: a PET study. Prog Neuropsychopharmacol Biol Psychiatry 23:657–668. doi:10.1016/S0278-5846(99) 00024-X CrossRefPubMed

41.

Muller RA, Rothermel RD, Behen ME, Muzik O, Mangner TJ, Chakraborty PK et al (1998) Brain organization of language after early unilateral lesion: a PET study. Brain Lang 62:422–451. doi:10.1006/brln.1997.1931 CrossRefPubMed

42.

Muller RA, Rothermel RD, Behen ME, Muzik O, Mangner TJ, Chugani HT (1998) Differential patterns of language and motor reorganization following early left hemisphere lesion: A PET study. Arch Neurol 55:1113–1119. doi:10.1001/archneur.55.8.1113 CrossRefPubMed

43.

Raichle ME, Martin WRW, Herscovitch P, Mintun MA, Markham J (1983) Brain blood flow measured with intravenous H2(15) O. II. Implementation and validation. J Nucl Med 24:790–798PubMed

44.

Rasmussen T, Milber B (1977) The role of early left-brain injury in determining lateralization of cerebral speech functions. Ann N Y Acad Sci 299:355–369. doi:10.1111/j.1749-6632.1977.tb41921.x CrossRefPubMed

45.

Robles SG, Gatignol P, Leherichy S, Duffau H (2008) Long-term brain plasticity allowing a multistage surgical approach to World Health Organization grade II gliomas in eloquent areas. J Neurosurg 109:615–624. doi:10.3171/JNS/2008/109/10/0615 CrossRefPubMed

46.

Saur D, Lange R, Baumgaertner A, Schraknepper V, Willmes K, Rijntjes M, Weiller C (2006) Dynamics of language reorganization after stroke. Brain 129:1371–1384. doi:10.1093/brain/awl090 CrossRefPubMed

47.

Schmahmann JD (1996) From movement to thought: anatomic substrates of the cerebellar contribution to cognitive processing. Hum Brain Mapp 4:174–198. doi:10.1002/(SICI)1097-0193(1996)4:3<174::AID-HBM3>3.0.CO;2-0 CrossRef

48.

Seitz RJ, Azari NP, Knorr U, Binkofski F, Herzog H, Freund HJ (1999) The role of diaschisis in stroke recovery. Stroke 30:1844–1850PubMed

49.

Selnes OA (2007) The ontogeny of cerebral language dominutesance. Brain Lang 71:217–220. doi:10.1006/brln.1999.2253 CrossRef

50.

Staudt M, Grodd W, Niemann G, Wildgruber D, Erb M, Krageloh-Mann I (2001) Early left periventricular brain lesions induce right hemispheric organization of speech. Neurology 57:122–125PubMed

51.

Tanriverdi T, Al Hinai Q, Mok K, Klein D, Poulin N, Olivier A (2009) Atypical language lateralization in patients with left hippocampal sclerosis: does the hippocampus affect language lateralization? Turk Neurosurg 19:1–14PubMed

52.

Thiel A, Habedank B, Winhuisen L, Herholz K, Kessler J, Haupt WF, Heiss WD (2005) Essential language function of the right hemisphere in brain tumor patients. Ann Neurol 57:128–131. doi:10.1002/ana.20342 CrossRefPubMed

53.

Thiel A, Herholz K, Koyuncu A, Ghaemi M, Kracht LW, Habedank B, Heiss WD (2001) Plasticity of language networks in patients with brain tumors: a positron emission tomography activation study. Ann Neurol 50:620–629. doi:10.1002/ana.1253 CrossRefPubMed

54.

Thiel A, Herholz K, von Stockhausen HM, van Leyen-Pilgram K, Pietrzyk U, Kessler J et al (1998) Localization of language-related cortex with ¹⁵O-labeled water PET in patients with gliomas. Neuroimage 7:284–295. doi:10.1006/nimg.1998.0334 CrossRefPubMed

55.

Ullian EM, Sapperstein SK, Christopherson KS, Barres BA (2001) Control of synapse number by glia. Science 291:657–661. doi:10.1126/science.291.5504.657 CrossRefPubMed

56.

Worsley KJ, Evans AC, Marrett S, Neelin P (1992) A three-dimensional statistical analysis for CBF activation studies in human brain. J Cereb Blood Flow Metab 12:900–918PubMed

Titel: Atypical speech activations: PET results of 92 patients with left-hemispheric epilepsy
verfasst von: Taner Tanriverdi
Denise Klein
Kelvin Mok
Sylvain Milot
Jasem Al-Hashel
Nicole Poulin
Andre Olivier
Publikationsdatum: 01.10.2009
Verlag: Springer Vienna
Erschienen in: Acta Neurochirurgica / Ausgabe 10/2009
Print ISSN: 0001-6268
Elektronische ISSN: 0942-0940
DOI: https://doi.org/10.1007/s00701-009-0373-7

Leitlinien kompakt für die Neurologie

Mit medbee Pocketcards sicher entscheiden.

^{Seit 2022 gehört die medbee GmbH zum Springer Medizin Verlag}

Kostenlos registrieren

Neu im Fachgebiet Neurologie

Niedriger diastolischer Blutdruck erhöht Risiko für schwere kardiovaskuläre Komplikationen

25.04.2024 Hypotonie Nachrichten

Wenn unter einer medikamentösen Hochdrucktherapie der diastolische Blutdruck in den Keller geht, steigt das Risiko für schwere kardiovaskuläre Ereignisse: Darauf deutet eine Sekundäranalyse der SPRINT-Studie hin.

Frühe Alzheimertherapie lohnt sich

25.04.2024 AAN-Jahrestagung 2024 Nachrichten

Ist die Tau-Last noch gering, scheint der Vorteil von Lecanemab besonders groß zu sein. Und beginnen Erkrankte verzögert mit der Behandlung, erreichen sie nicht mehr die kognitive Leistung wie bei einem früheren Start. Darauf deuten neue Analysen der Phase-3-Studie Clarity AD.

Viel Bewegung in der Parkinsonforschung

25.04.2024 Parkinson-Krankheit Nachrichten

Neue arznei- und zellbasierte Ansätze, Frühdiagnose mit Bewegungssensoren, Rückenmarkstimulation gegen Gehblockaden – in der Parkinsonforschung tut sich einiges. Auf dem Deutschen Parkinsonkongress ging es auch viel um technische Innovationen.

Demenzkranke durch Antipsychotika vielfach gefährdet

23.04.2024 Demenz Nachrichten

Wenn Demenzkranke aufgrund von Symptomen wie Agitation oder Aggressivität mit Antipsychotika behandelt werden, sind damit offenbar noch mehr Risiken verbunden als bislang angenommen.

Update Neurologie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.

Newsletter bestellen

Springer Medizin

Abstract

Purpose

Methods

Results

Conclusions

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

Weitere Artikel der Ausgabe 10/2009

Restoration of sexual activity in patients with chronic hydrocephalus after shunt placement

Reducible and irreducible os odontoideum in childhood treated with posterior wiring, instrumentation and fusion. Past or present?

Response to Wang et al., re Letter re Visocchi M, Pietrini D, Tufo T, Fernandez E, Di Rocco C (2009) Pre-operative irreducible C1–C2 dislocations: intra-operative reduction and posterior fixation. The “always posterior strategy”. Acta Neurochir (Wien) 151(5):551–9; discussion 560

Vertebral artery dissection as an extremely rare cause of spinal epidural hematoma: case report and review of the literature

Visocchi M, Pietrini D, Tufo T, Fernandez E, Di Rocco C (2009) Pre-operative irreducible C1–C2 dislocations: intra-operative reduction and posterior fixation. The "always posterior strategy". Acta Neurochir 151(5):551–560; discussion