Background
Methods
Study site and study population
Audiology tests
Otoscopy and tympanometry
Audiometry
Auditory brainstem response (ABR)
Treatment
Follow up procedure
Statistical analysis
Results
Patients' characteristics | All patients |
---|---|
Male (n = 74) | 79.6% |
Age (in years)a | 26.6 (8.8) [13–53], 13.7 – 41.2 |
Weight (in kg)a | 50.7 (7.1) [30.0–70.0], 39.7 – 63.0 |
Tympanic temperature (in °C)a | 37.2 (1.1) [34.9–40.1], 35.8 – 39.0 |
Mixed infection, PF+PV (n = 16) | 17.2% |
Geometric mean parasite count per μl [range] | 7386 [79–190546] |
Total artesunate dose (in mg)b | 600 [300–825] |
Previous artesunate treatment (n = 26) | 28% |
Time of last artesunate treatment (in month)b | 4 [1 – 8] |
Tympanometry characteristics
| |
Middle ear pressure, left ear (in daP)b | -15 [-145 – +25] |
Middle ear pressure, right ear (in daP)b | -15 [-140 – +95] |
Static compliance, left ear (in ml)b | 0.48 [0.16–3.08] |
Static compliance, right ear (in ml)b | 0.46 [0.15–2.52] |
Tympanometric gradient, left ear (dimensionless)a | 0.49 (0.15) [0.19–0.83], 0.22 – 0.77 |
Tympanometric gradient, right ear (dimensionless)a | 0.46 (0.15) [0.09–0.81], 0.23 – 0.74 |
Tympanometry
Audiometry
Auditory brainstem response
Peak latencies | Inter-latencies | |||||
---|---|---|---|---|---|---|
Wave I
|
Wave III
|
Wave V
|
I–III
|
III–V
|
I–V
| |
Day 0 | ||||||
Left ear | 1.52 (0.14) | 3.67 (0.15) | 5.45 (0.22) | 2.15 (0.16) | 1.78 (0.17) | 3.93 (0.24) |
Right ear | 1.55 (0.13) | 3.65 (0.14) | 5.44 (0.23) | 2.10 (0.16) | 1.79 (0.17) | 3.89 (0.25) |
Day 7 | ||||||
Left ear | 1.55 (0.14) | 3.73 (0.16) | 5.51 (0.22) | 2.18 (0.17) | 1.78 (0.17) | 3.96 (0.24) |
Right ear | 1.57 (0.13) | 3.71 (0.14) | 5.54 (0.23) | 2.14 (0.17) | 1.82 (0.17) | 3.97 (0.25) |
Difference D7-D0 | ||||||
Left ear | 0.03 (0.07) | 0.07 (0.09) | 0.07 (0.11) | 0.04 (0.10) | 0.00 (0.08) | 0.04 (0.12) |
P value | < 0.001 | < 0.001 | < 0.001 | 0.001 | 0.892 | 0.003 |
Right ear | 0.02 (0.06) | 0.07 (0.08) | 0.09 (0.13) | 0.05 (0.08) | 0.03 (0.11) | 0.07 (0.13) |
P value | 0.003 | < 0.001 | < 0.001 | < 0.001 | 0.017 | < 0.001 |