Erschienen in:
Open Access
01.12.2012 | Oral presentation
Autoimmune arthritis caused by altered thymic T-cell selection due to a mutation of the ZAP-70 gene
verfasst von:
Yoshinaga Ito, Shimon Sakaguchi
Erschienen in:
Arthritis Research & Therapy
|
Sonderheft 1/2012
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Excerpt
SKG mouse is a murine model of autoimmune arthritis. A spontaneous point mutation of the gene encoding an SH2 domain of the ζ-associated protein of 70 kDa gene (ZAP-70), a key signal transduction molecule in T cells, causes chronic autoimmune arthritis in SKG mice that resembles human RA in many aspects. Altered signal transduction from T-cell antigen receptor through the aberrant ZAP-70 changes the thresholds of T cells to thymic selection, leading to the positive selection of otherwise negatively selected autoimmune T cells. …