Erschienen in:
01.11.2012 | Short Communication
Beta cell nuclear musculoaponeurotic fibrosarcoma oncogene family A (MafA) is deficient in type 2 diabetes
verfasst von:
A. E. Butler, R. P. Robertson, R. Hernandez, A. V. Matveyenko, T. Gurlo, P. C. Butler
Erschienen in:
Diabetologia
|
Ausgabe 11/2012
Einloggen, um Zugang zu erhalten
Abstract
Aims/hypothesis
The beta cell transcriptional factor musculoaponeurotic fibrosarcoma oncogene family A (MafA) regulates genes important for beta cell function. Loss of nuclear MafA has been implicated in beta cell dysfunction in animal models of type 2 diabetes. We sought to establish if nuclear MafA is less abundant in beta cell nuclei in humans with type 2 diabetes.
Methods
Pancreas obtained at surgery from five non-diabetic individuals and six individuals with type 2 diabetes was immunostained for insulin, glucagon and MafA.
Results
Beta cell nuclear MafA was markedly decreased in type 2 diabetes (1.6 ± 1.2% vs 46.3 ± 8.3%, p < 0.001).
Conclusions/interpretation
Beta cell nuclear MafA is markedly decreased in humans with type 2 diabetes, which may contribute to impaired beta cell dysfunction.