Erschienen in:
07.11.2019 | Case Report
Bevacizumab for optic pathway glioma with worsening visual field in absence of imaging progression: 2 case reports and literature review
verfasst von:
Fumiyuki Yamasaki, Motoki Takano, Ushio Yonezawa, Akira Taguchi, Manish Kolakshyapati, Hideaki Okumichi, Yoshiaki Kiuchi, Kaoru Kurisu
Erschienen in:
Child's Nervous System
|
Ausgabe 3/2020
Einloggen, um Zugang zu erhalten
Abstract
Children with optic pathway gliomas (OPGs) frequently suffer from problems of visual function resulting from tumors. Previous reports showed that bevacizumab improved visual function in patients with OPG via tumor response to treatment. In these two case reports, we show that bevacizumab improved visual field without tumor response as seen in imaging. Both, a 10-year-old girl and a 6-year-old boy, had previous history of treatment with platinum-based chemotherapy. They had visual deterioration without tumor progression on MR imaging. Bevacizumab effectively and immediately improved visual field in both patients without imaging response of OPG. We emphasize that bevacizumab should be considered for patients with OPGs having visual deterioration without tumor progression.