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Erschienen in: Pathology & Oncology Research 4/2018

28.12.2017 | Review

Beyond Conventional Medicine - a Look at Blueberry, a Cancer-Fighting Superfruit

verfasst von: Kristoffer T. Davidson, Ziwen Zhu, Dean Balabanov, Lei Zhao, Mark R. Wakefield, Qian Bai, Yujiang Fang

Erschienen in: Pathology & Oncology Research | Ausgabe 4/2018

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Abstract

Nearly 40% of men and women will be diagnosed with cancer during their lifetime. Thus, there is a rapidly growing need for novel therapies to combat this deadly disease. One such method is the consumption of blueberries. Long coveted for their powerful antioxidant properties, more recent studies have demonstrated that blueberries also exhibit inherent abilities to prevent carcinogenesis, inhibit the proliferation of neoplastic cells, and reduce the risks of recurrence in patients in remission. This review will focus on the specific activities of blueberry derivatives in cancer cells across many different forms of cancer. Ultimately, such research could be helpful in the development of new strategies to treat cancer.
Literatur
2.
Zurück zum Zitat Slattery ML, Lundgreen A, Torres-Mejia G, Wolff RK, Hines L, Baumgartner K, John EM (2014) Diet and lifestyle factors modify immune/inflammation response genes to alter breast cancer risk and prognosis: the breast cancer health disparities study. Mutat Res Fundam Mol Mech Mutagen 770:19–28CrossRef Slattery ML, Lundgreen A, Torres-Mejia G, Wolff RK, Hines L, Baumgartner K, John EM (2014) Diet and lifestyle factors modify immune/inflammation response genes to alter breast cancer risk and prognosis: the breast cancer health disparities study. Mutat Res Fundam Mol Mech Mutagen 770:19–28CrossRef
3.
Zurück zum Zitat Lee G-Y, Lee JJ, Lee S-M (2015) Antioxidant and anticoagulant status were improved by personalized dietary intervention based on biochemical and clinical parameters in cancer patients. Nutr Cancer 67(7):1083–1092CrossRefPubMed Lee G-Y, Lee JJ, Lee S-M (2015) Antioxidant and anticoagulant status were improved by personalized dietary intervention based on biochemical and clinical parameters in cancer patients. Nutr Cancer 67(7):1083–1092CrossRefPubMed
4.
5.
Zurück zum Zitat Kresty LA, Weh KM, Zeyzus-Johns B, Perez LN, Howell AB (2015) Cranberry proanthocyanidins inhibit esophageal adenocarcinoma in vitro and in vivo through pleiotropic cell death induction and PI3K/AKT/mTOR inactivation. Oncotarget 6(32):33438CrossRefPubMedPubMedCentral Kresty LA, Weh KM, Zeyzus-Johns B, Perez LN, Howell AB (2015) Cranberry proanthocyanidins inhibit esophageal adenocarcinoma in vitro and in vivo through pleiotropic cell death induction and PI3K/AKT/mTOR inactivation. Oncotarget 6(32):33438CrossRefPubMedPubMedCentral
6.
Zurück zum Zitat Jeyabalan J, Aqil F, Munagala R, Annamalai L, Vadhanam MV, Gupta RC (2014) Chemopreventive and therapeutic activity of dietary blueberry against estrogen-mediated breast cancer. J Agric Food Chem 62(18):3963–3971CrossRefPubMed Jeyabalan J, Aqil F, Munagala R, Annamalai L, Vadhanam MV, Gupta RC (2014) Chemopreventive and therapeutic activity of dietary blueberry against estrogen-mediated breast cancer. J Agric Food Chem 62(18):3963–3971CrossRefPubMed
7.
Zurück zum Zitat Chen C, Li Y, Xu Z (2010) Chemical principles and bioactivities of blueberry. Yao xue xue bao=Acta Pharm Sin 45(4):422–429 Chen C, Li Y, Xu Z (2010) Chemical principles and bioactivities of blueberry. Yao xue xue bao=Acta Pharm Sin 45(4):422–429
8.
Zurück zum Zitat Johnson SA, Arjmandi BH (2013) Evidence for anti-cancer properties of blueberries: a mini-review. Anticancer Agents Med (Formerly Curr Med Chem: Anti-Cancer Agents) 13(8):1142–1148CrossRef Johnson SA, Arjmandi BH (2013) Evidence for anti-cancer properties of blueberries: a mini-review. Anticancer Agents Med (Formerly Curr Med Chem: Anti-Cancer Agents) 13(8):1142–1148CrossRef
9.
Zurück zum Zitat Howlader N, Noone A, Krapcho M, Garshell J, Neyman N, Altekruse S, Kosary C, Yu M, Ruhl J, Tatalovich Z (2013) SEER cancer statistics review, Natl Cancer Inst. Bethesda (1975–2010) Howlader N, Noone A, Krapcho M, Garshell J, Neyman N, Altekruse S, Kosary C, Yu M, Ruhl J, Tatalovich Z (2013) SEER cancer statistics review, Natl Cancer Inst. Bethesda (1975–2010)
10.
Zurück zum Zitat Adams LS, Phung S, Yee N, Seeram NP, Li L, Chen S (2010) Blueberry phytochemicals inhibit growth and metastatic potential of MDA-MB-231 breast cancer cells through modulation of the phosphatidylinositol 3-kinase pathway. Cancer Res 70(9):3594–3605CrossRefPubMedPubMedCentral Adams LS, Phung S, Yee N, Seeram NP, Li L, Chen S (2010) Blueberry phytochemicals inhibit growth and metastatic potential of MDA-MB-231 breast cancer cells through modulation of the phosphatidylinositol 3-kinase pathway. Cancer Res 70(9):3594–3605CrossRefPubMedPubMedCentral
11.
Zurück zum Zitat Montales MTE, Rahal OM, Kang J, Rogers T, Prior RL, Wu X, Simmen RC (2012) Repression of mammosphere formation of human breast cancer cells by soy isoflavone genistein and blueberry polyphenolic acids suggests diet-mediated targeting of cancer stem-like/progenitor cells. Carcinogenesis 33(3):652–660CrossRefPubMed Montales MTE, Rahal OM, Kang J, Rogers T, Prior RL, Wu X, Simmen RC (2012) Repression of mammosphere formation of human breast cancer cells by soy isoflavone genistein and blueberry polyphenolic acids suggests diet-mediated targeting of cancer stem-like/progenitor cells. Carcinogenesis 33(3):652–660CrossRefPubMed
12.
Zurück zum Zitat Kanaya N, Adams L, Takasaki A, Chen S (2014) Whole blueberry powder inhibits metastasis of triple negative breast cancer in a xenograft mouse model through modulation of inflammatory cytokines. Nutr Cancer 66(2):242–248CrossRefPubMed Kanaya N, Adams L, Takasaki A, Chen S (2014) Whole blueberry powder inhibits metastasis of triple negative breast cancer in a xenograft mouse model through modulation of inflammatory cytokines. Nutr Cancer 66(2):242–248CrossRefPubMed
13.
Zurück zum Zitat Ravoori S, Vadhanam MV, Aqil F, Gupta RC (2012) Inhibition of estrogen-mediated mammary tumorigenesis by blueberry and black raspberry. J Agric Food Chem 60(22):5547–5555CrossRefPubMed Ravoori S, Vadhanam MV, Aqil F, Gupta RC (2012) Inhibition of estrogen-mediated mammary tumorigenesis by blueberry and black raspberry. J Agric Food Chem 60(22):5547–5555CrossRefPubMed
14.
Zurück zum Zitat Bruix J, Sherman M (2011) Management of hepatocellular carcinoma: an update. Hepatology 53(3):1020–1022CrossRefPubMed Bruix J, Sherman M (2011) Management of hepatocellular carcinoma: an update. Hepatology 53(3):1020–1022CrossRefPubMed
15.
Zurück zum Zitat Yi W, Akoh CC, Fischer J, Krewer G (2006) Effects of phenolic compounds in blueberries and muscadine grapes on HepG2 cell viability and apoptosis. Food Res Int 39(5):628–638CrossRef Yi W, Akoh CC, Fischer J, Krewer G (2006) Effects of phenolic compounds in blueberries and muscadine grapes on HepG2 cell viability and apoptosis. Food Res Int 39(5):628–638CrossRef
16.
Zurück zum Zitat Bingül İ, Başaran-Küçükgergin C, Tekkeşin MS, Olgaç V, Doğru-Abbasoğlu S, Uysal M (2013) Effect of blueberry pretreatment on diethylnitrosamine-induced oxidative stress and liver injury in rats. Environ Toxicol Pharmacol 36(2):529–538CrossRefPubMed Bingül İ, Başaran-Küçükgergin C, Tekkeşin MS, Olgaç V, Doğru-Abbasoğlu S, Uysal M (2013) Effect of blueberry pretreatment on diethylnitrosamine-induced oxidative stress and liver injury in rats. Environ Toxicol Pharmacol 36(2):529–538CrossRefPubMed
17.
Zurück zum Zitat Bingül İ, Başaran-Küçükgergin C, Aydın AF, Soluk-Tekkeşin M, Olgaç V, Doğru-Abbasoğlu S, Uysal M (2015) Blueberry treatment attenuated cirrhotic and preneoplastic lesions and oxidative stress in the liver of diethylnitrosamine-treated rats. Int J Immunopathol Pharmacol 29(3):426–37 Bingül İ, Başaran-Küçükgergin C, Aydın AF, Soluk-Tekkeşin M, Olgaç V, Doğru-Abbasoğlu S, Uysal M (2015) Blueberry treatment attenuated cirrhotic and preneoplastic lesions and oxidative stress in the liver of diethylnitrosamine-treated rats. Int J Immunopathol Pharmacol 29(3):426–37
18.
Zurück zum Zitat Zhan W, Liao X, Yu L, Tian T, Liu X, Liu J, Cai L-J, Xiao X, Xie R-J, Yang Q (2016) Effects of blueberries on migration, invasion, proliferation, the cell cycle and apoptosis in hepatocellular carcinoma cells. Biomedical reports 5(5):579–584CrossRefPubMedPubMedCentral Zhan W, Liao X, Yu L, Tian T, Liu X, Liu J, Cai L-J, Xiao X, Xie R-J, Yang Q (2016) Effects of blueberries on migration, invasion, proliferation, the cell cycle and apoptosis in hepatocellular carcinoma cells. Biomedical reports 5(5):579–584CrossRefPubMedPubMedCentral
19.
Zurück zum Zitat Yi W, Fischer J, Krewer G, Akoh CC (2005) Phenolic compounds from blueberries can inhibit colon cancer cell proliferation and induce apoptosis. J Agric Food Chem 53(18):7320–7329CrossRefPubMed Yi W, Fischer J, Krewer G, Akoh CC (2005) Phenolic compounds from blueberries can inhibit colon cancer cell proliferation and induce apoptosis. J Agric Food Chem 53(18):7320–7329CrossRefPubMed
20.
Zurück zum Zitat Suh N, Paul S, Hao X, Simi B, Xiao H, Rimando AM, Reddy BS (2007) Pterostilbene, an active constituent of blueberries, suppresses aberrant crypt foci formation in the azoxymethane-induced colon carcinogenesis model in rats. Clin Cancer Res 13(1):350–355CrossRefPubMed Suh N, Paul S, Hao X, Simi B, Xiao H, Rimando AM, Reddy BS (2007) Pterostilbene, an active constituent of blueberries, suppresses aberrant crypt foci formation in the azoxymethane-induced colon carcinogenesis model in rats. Clin Cancer Res 13(1):350–355CrossRefPubMed
21.
Zurück zum Zitat Minker C, Duban L, Karas D, Järvinen P, Lobstein A, Muller CD (2015) Impact of procyanidins from different berries on caspase 8 activation in colon cancer. Oxidative Med Cell Longev 2015:1–13CrossRef Minker C, Duban L, Karas D, Järvinen P, Lobstein A, Muller CD (2015) Impact of procyanidins from different berries on caspase 8 activation in colon cancer. Oxidative Med Cell Longev 2015:1–13CrossRef
22.
Zurück zum Zitat Qi C, Li S, Jia Y, Wang L (2014) [Blueberry anthocyanins induce G2/M cell cycle arrest and apoptosis of oral cancer KB cells through down-regulation methylation of p53]. Yi chuan= Hereditas/Zhongguo yi chuan xue hui bian ji 36 (6):566–573 Qi C, Li S, Jia Y, Wang L (2014) [Blueberry anthocyanins induce G2/M cell cycle arrest and apoptosis of oral cancer KB cells through down-regulation methylation of p53]. Yi chuan= Hereditas/Zhongguo yi chuan xue hui bian ji 36 (6):566–573
23.
Zurück zum Zitat Baba AB, Kowshik J, Krishnaraj J, Sophia J, Dixit M, Nagini S (2016) Blueberry inhibits invasion and angiogenesis in 7, 12-dimethylbenz [a] anthracene (DMBA)-induced oral squamous cell carcinogenesis in hamsters via suppression of TGF-β and NF-κB signaling pathways. J Nutr Biochem 35:37–47CrossRefPubMed Baba AB, Kowshik J, Krishnaraj J, Sophia J, Dixit M, Nagini S (2016) Blueberry inhibits invasion and angiogenesis in 7, 12-dimethylbenz [a] anthracene (DMBA)-induced oral squamous cell carcinogenesis in hamsters via suppression of TGF-β and NF-κB signaling pathways. J Nutr Biochem 35:37–47CrossRefPubMed
24.
Zurück zum Zitat Schmidt BM, Erdman JW, Lila MA (2006) Differential effects of blueberry proanthocyanidins on androgen sensitive and insensitive human prostate cancer cell lines. Cancer Lett 231(2):240–246CrossRefPubMed Schmidt BM, Erdman JW, Lila MA (2006) Differential effects of blueberry proanthocyanidins on androgen sensitive and insensitive human prostate cancer cell lines. Cancer Lett 231(2):240–246CrossRefPubMed
25.
Zurück zum Zitat Matchett MD, MacKinnon SL, Sweeney MI, Gottschall-Pass KT, Hurta RA (2006) Inhibition of matrix metalloproteinase activity in DU145 human prostate cancer cells by flavonoids from lowbush blueberry (Vaccinium Angustifolium): possible roles for protein kinase C and mitogen-activated protein-kinase-mediated events. J Nutr Biochem 17(2):117–125CrossRefPubMed Matchett MD, MacKinnon SL, Sweeney MI, Gottschall-Pass KT, Hurta RA (2006) Inhibition of matrix metalloproteinase activity in DU145 human prostate cancer cells by flavonoids from lowbush blueberry (Vaccinium Angustifolium): possible roles for protein kinase C and mitogen-activated protein-kinase-mediated events. J Nutr Biochem 17(2):117–125CrossRefPubMed
26.
Zurück zum Zitat Kausar H, Jeyabalan J, Aqil F, Chabba D, Sidana J, Singh IP, Gupta RC (2012) Berry anthocyanidins synergistically suppress growth and invasive potential of human non-small-cell lung cancer cells. Cancer Lett 325(1):54–62CrossRefPubMed Kausar H, Jeyabalan J, Aqil F, Chabba D, Sidana J, Singh IP, Gupta RC (2012) Berry anthocyanidins synergistically suppress growth and invasive potential of human non-small-cell lung cancer cells. Cancer Lett 325(1):54–62CrossRefPubMed
27.
Zurück zum Zitat Diaconeasa Z, Leopold L, Rugină D, Ayvaz H, Socaciu C (2015) Antiproliferative and antioxidant properties of anthocyanin rich extracts from blueberry and blackcurrant juice. Int J Mol Sci 16(2):2352–2365CrossRefPubMedPubMedCentral Diaconeasa Z, Leopold L, Rugină D, Ayvaz H, Socaciu C (2015) Antiproliferative and antioxidant properties of anthocyanin rich extracts from blueberry and blackcurrant juice. Int J Mol Sci 16(2):2352–2365CrossRefPubMedPubMedCentral
28.
Zurück zum Zitat Bunea A, Rugină D, Sconţa Z, Pop RM, Pintea A, Socaciu C, Tăbăran F, Grootaert C, Struijs K, VanCamp J (2013) Anthocyanin determination in blueberry extracts from various cultivars and their antiproliferative and apoptotic properties in B16-F10 metastatic murine melanoma cells. Phytochemistry 95:436–444CrossRefPubMed Bunea A, Rugină D, Sconţa Z, Pop RM, Pintea A, Socaciu C, Tăbăran F, Grootaert C, Struijs K, VanCamp J (2013) Anthocyanin determination in blueberry extracts from various cultivars and their antiproliferative and apoptotic properties in B16-F10 metastatic murine melanoma cells. Phytochemistry 95:436–444CrossRefPubMed
29.
Zurück zum Zitat Davidson KT, Zhu Z, Bai Q, Xiao H, Wakefield MR, Fang Y (2017) Blueberry as a potential Radiosensitizer for treating cervical cancer. Pathol Oncol Res 22(4):655–60 Davidson KT, Zhu Z, Bai Q, Xiao H, Wakefield MR, Fang Y (2017) Blueberry as a potential Radiosensitizer for treating cervical cancer. Pathol Oncol Res 22(4):655–60
30.
Zurück zum Zitat Fang Y, Moore BJ, Bai Q, Cook KM, Herrick EJ, Nicholl MB (2013) Hydrogen peroxide enhances radiation-induced apoptosis and inhibition of melanoma cell proliferation. Anticancer Res 33(5):1799–1807PubMed Fang Y, Moore BJ, Bai Q, Cook KM, Herrick EJ, Nicholl MB (2013) Hydrogen peroxide enhances radiation-induced apoptosis and inhibition of melanoma cell proliferation. Anticancer Res 33(5):1799–1807PubMed
31.
Zurück zum Zitat Fang Y, Bradley MJ, Cook KM, Herrick EJ, Nicholl MB (2013) A potential role for resveratrol as a radiation sensitizer for melanoma treatment. J Surg Res 183(2):645–653CrossRefPubMed Fang Y, Bradley MJ, Cook KM, Herrick EJ, Nicholl MB (2013) A potential role for resveratrol as a radiation sensitizer for melanoma treatment. J Surg Res 183(2):645–653CrossRefPubMed
32.
Zurück zum Zitat Fang Y, DeMarco VG, Nicholl MB (2012) Resveratrol enhances radiation sensitivity in prostate cancer by inhibiting cell proliferation and promoting cell senescence and apoptosis. Cancer Sci 103(6):1090–1098CrossRefPubMedPubMedCentral Fang Y, DeMarco VG, Nicholl MB (2012) Resveratrol enhances radiation sensitivity in prostate cancer by inhibiting cell proliferation and promoting cell senescence and apoptosis. Cancer Sci 103(6):1090–1098CrossRefPubMedPubMedCentral
33.
Zurück zum Zitat Gordillo G, Fang H, Khanna S, Harper J, Phillips G, Sen CK (2009) Oral administration of blueberry inhibits angiogenic tumor growth and enhances survival of mice with endothelial cell neoplasm. Antioxid Redox Signal 11(1):47–58CrossRefPubMedPubMedCentral Gordillo G, Fang H, Khanna S, Harper J, Phillips G, Sen CK (2009) Oral administration of blueberry inhibits angiogenic tumor growth and enhances survival of mice with endothelial cell neoplasm. Antioxid Redox Signal 11(1):47–58CrossRefPubMedPubMedCentral
34.
Zurück zum Zitat Kai H, Akamatsu E, Torii E, Kodama H, Yukizaki C, Sakakibara Y, Suiko M, Morishita K, Kataoka H, Matsuno K (2011) Inhibition of proliferation by agricultural plant extracts in seven human adult T-cell leukaemia (ATL)-related cell lines. J Nat Med 65(3–4):651–655CrossRefPubMed Kai H, Akamatsu E, Torii E, Kodama H, Yukizaki C, Sakakibara Y, Suiko M, Morishita K, Kataoka H, Matsuno K (2011) Inhibition of proliferation by agricultural plant extracts in seven human adult T-cell leukaemia (ATL)-related cell lines. J Nat Med 65(3–4):651–655CrossRefPubMed
Metadaten
Titel
Beyond Conventional Medicine - a Look at Blueberry, a Cancer-Fighting Superfruit
verfasst von
Kristoffer T. Davidson
Ziwen Zhu
Dean Balabanov
Lei Zhao
Mark R. Wakefield
Qian Bai
Yujiang Fang
Publikationsdatum
28.12.2017
Verlag
Springer Netherlands
Erschienen in
Pathology & Oncology Research / Ausgabe 4/2018
Print ISSN: 1219-4956
Elektronische ISSN: 1532-2807
DOI
https://doi.org/10.1007/s12253-017-0376-2

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