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Journal of Natural Medicines

Erschienen in:

01.04.2016 | Original Paper

Bioactive cyclolanstane-type saponins from the stems of Astragalus membranaceus (Fisch.) Bge. var. mongholicus (Bge.) Hsiao

verfasst von: Tingting Wang, Jingya Ruan, Xiaoxia Li, Liping Chao, Pingping Shi, Lifeng Han, Yi Zhang, Tao Wang

Erschienen in: Journal of Natural Medicines | Ausgabe 2/2016

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Abstract

Twelve cyclolanstane-type saponins including six new ones, astrolanosaponins A₁ (1), A₂ (2), B (3), C (4), D (5), and E (6) were obtained from the stem of Astragalus membranaceus (Fisch.) Bge. var. mongholicus (Bge.) Hsiao, and their structures were elucidated by chemical and spectroscopic methods. Of the known ones, cycloastragenol-3-O-β-D-glucopyranoside (7), astraverrucin II (8), cycloaraloside E (9), huangqiyenin A (10), and huangqiyenin B (11) were isolated from the species first. Meanwhile, compounds 1–3, 5–9, and aleksandroside I (12) showed inhibitory effects on triglyceride accumulation in HepG2 cells.

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Titel: Bioactive cyclolanstane-type saponins from the stems of Astragalus membranaceus (Fisch.) Bge. var. mongholicus (Bge.) Hsiao
verfasst von: Tingting Wang
Jingya Ruan
Xiaoxia Li
Liping Chao
Pingping Shi
Lifeng Han
Yi Zhang
Tao Wang
Publikationsdatum: 01.04.2016
Verlag: Springer Japan
Erschienen in: Journal of Natural Medicines / Ausgabe 2/2016
Print ISSN: 1340-3443
Elektronische ISSN: 1861-0293
DOI: https://doi.org/10.1007/s11418-015-0959-8

Springer Medizin

Abstract

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