nach oben

Inflammopharmacology

Erschienen in:

20.10.2018 | Review

Black pepper and its bioactive constituent piperine: promising therapeutic strategies for oral lichen planus

verfasst von: Jing-Ya Yang, Jing Zhang, Gang Zhou

Erschienen in: Inflammopharmacology | Ausgabe 1/2019

Einloggen, um Zugang zu erhalten

Abstract

Oral lichen planus (OLP) is a common T cell-mediated chronic inflammatory disease with malignant potential and unclear etiology. The present study suggests that antigen-specific mechanisms in which dentritic cells, T lymphocytes and NF-κB signaling pathway play critical roles, are involved in the pathogenesis of OLP. Additionally, it has been indicated that altered expression of cyclooxygenase 2 (COX-2) and imbalanced oxidant-antioxidant status as well as psychological issue may act as promoters to the development of OLP. Therapies for OLP are primarily aimed to control symptoms and a specific cure is not yet available. Black pepper and its principle bioactive compound piperine have been reported to possess remarkable pharmacological activities. Not only has piperine been evidenced to exhibit repressive effects on the maturation of dentritic cells, the proliferation, activation and function of T lymphocytes as well as the NF-κB signaling pathway, but also to suppress the overproduction of COX-2 and weaken the oxidative stress. Furthermore, piperine might be a possible agent for alleviating psychological disorders and preventing carcinogenesis. Given all these into consideration, piperine may be a novel and effective therapeutic strategy for OLP.

Abdel HRM, Fawzy MM, Metwally D et al (2012) DNA polymorphisms and tissue cyclooxygenase-2 expression in oral lichen planus: a case–control study. J Eur Acad Dermatol Venereol 26(9):1122–1126CrossRef

Abdolsamadi H, Rafieian N, Goodarzi MT et al (2014) Levels of salivary antioxidant vitamins and lipid peroxidation in patients with oral lichen planus and healthy individuals. Chonnam Med J. 50(2):58–62CrossRefPubMedPubMedCentral

Agha-Hosseini F, Mirzaii-Dizgah I, Mikaili S, Abdollahi M (2009) Increased salivary lipid peroxidation in human subjects with oral lichen planus. Int J Dent Hyg. 7(4):246–250CrossRefPubMed

Alrashdan MS, Cirillo N, McCullough M (2016) Oral lichen planus: a literature review and update. Arch Dermatol Res 308(8):539–551CrossRefPubMed

Alshahrani S, Baccaglini L (2014) Psychological screening test results for stress, depression, and anxiety are variably associated with clinical severity of recurrent aphthous stomatitis and oral lichen planus. J Evid Based Dent Pract. 14(4):206–208CrossRefPubMed

Alves MG, Do Carmo Carvalho BF, Balducci I, Cabral LA, Nicodemo D, Almeida JD (2015) Emotional assessment of patients with oral lichen planus. Int J Dermatol 54(1):29–32CrossRefPubMed

Amirchaghmaghi M, Hashemy SI, Alirezaei B et al (2016) Evaluation of plasma isoprostane in patients with oral lichen planus. J Dent (Shiraz). 17(1):21–25PubMedCentral

Azizi A, Farshchi F (2012) Comparison of salivary and plasma antioxidant levels in lichen planus patients and healthy subjects. J Oral Pathol Med 41(7):524–526PubMed

Bae GS, Kim MS, Jung WS et al (2010) Inhibition of lipopolysaccharide-induced inflammatory responses by piperine. Eur J Pharmacol 642(1–3):154–162CrossRefPubMed

Bae GS, Kim JJ, Park KC et al (2012) Piperine inhibits lipopolysaccharide-induced maturation of bone-marrow-derived dendritic cells through inhibition of ERK and JNK activation. Phytother Res. 26(12):1893–1897CrossRefPubMed

Balkwill F, Mantovani A (2001) Inflammation and cancer: back to Virchow. Lancet 357(9255):539–545CrossRefPubMed

Bang JS, Oh DH, Choi HM et al (2009) Anti-inflammatory and antiarthritic effects of piperine in human interleukin 1beta-stimulated fibroblast-like synoviocytes and in rat arthritis models. Arthritis Res Ther. 11(2):R49CrossRefPubMedPubMedCentral

Barrett AW, Cruchley AT, Williams DM (1996) Oral mucosal Langerhans’ cells. Crit Rev Oral Biol Med 7(1):36–58CrossRefPubMed

Battino M, Greabu M, Totan A et al (2008) Oxidative stress markers in oral lichen planus. BioFactors 33(4):301–310CrossRefPubMed

Bayer AL, Pugliese A, Malek TR (2013) The IL-2/IL-2R system: from basic science to therapeutic applications to enhance immune regulation. Immunol Res 57(1–3):197–209CrossRefPubMedPubMedCentral

Buczko P, Zalewska A, Szarmach I (2015) Saliva and oxidative stress in oral cavity and in some systemic disorders. J Physiol Pharmacol 66(1):3–9PubMed

Butt MS, Pasha I, Sultan MT, Randhawa MA, Saeed F, Ahmed W (2013) Black pepper and health claims: a comprehensive treatise. Crit Rev Food Sci Nutr 53(9):875–886CrossRefPubMed

Chen Y, Zhang W, Geng N, Tian K, Jack WL (2008) MMPs, TIMP-2, and TGF-beta1 in the cancerization of oral lichen planus. Head Neck 30(9):1237–1245CrossRefPubMed

Chuchawankul S, Khorana N, Poovorawan Y (2012) Piperine inhibits cytokine production by human peripheral blood mononuclear cells. Genet Mol Res 11(1):617–627CrossRefPubMed

Cortés-Ramírez DA, Rodríguez-Tojo MJ, Gainza-Cirauqui ML, Martínez-Conde R, Aguirre-Urizar JM (2010) Overexpression of cyclooxygenase-2 as a biomarker in different subtypes of the oral lichenoid disease. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 110(6):738–743CrossRefPubMed

Crincoli V, Di BMB, Scivetti M, Lucchese A, Tecco S, Festa F (2011) Oral lichen planus: update on etiopathogenesis, diagnosis and treatment. Immunopharmacol Immunotoxicol 33(1):11–20CrossRefPubMed

Danielsson K, Ebrahimi M, Wahlin YB, Nylander K, Boldrup L (2012) Increased levels of COX-2 in oral lichen planus supports an autoimmune cause of the disease. J Eur Acad Dermatol Venereol 26(11):1415–1419CrossRefPubMed

Darczuk D, Krzysciak W, Vyhouskaya P et al (2016) Salivary oxidative status in patients with oral lichen planus. J Physiol Pharmacol 67(6):885–894PubMed

Deng Y, Sriwiriyajan S, Tedasen A, Hiransai P, Graidist P (2016) Anti-cancer effects of Piper nigrum via inducing multiple molecular signaling in vivo and in vitro. J Ethnopharmacol 188:87–95CrossRefPubMed

Derosa G, Maffioli P, Sahebkar A (2016) Piperine and its role in chronic diseases. Adv Exp Med Biol 928:173–184CrossRefPubMed

Doucette CD, Greenshields AL, Liwski RS, Hoskin DW (2015a) Piperine blocks interleukin-2-driven cell cycle progression in CTLL-2 T lymphocytes by inhibiting multiple signal transduction pathways. Toxicol Lett 234(1):1–12CrossRefPubMed

Doucette CD, Rodgers G, Liwski RS, Hoskin DW (2015b) Piperine from black pepper inhibits activation-induced proliferation and effector function of T lymphocytes. J Cell Biochem 116(11):2577–2588CrossRefPubMed

Edwards PC, Kelsch R (2002) Oral lichen planus: clinical presentation and management. J Can Dent Assoc 68(8):494–499PubMed

El-Rifaie AA, Rashed LA, Doss RW (2015) The role of cyclooxygenase-2 and prostaglandin E2 in the pathogenesis of cutaneous lichen planus. Clin Exp Dermatol 40(8):903–907CrossRefPubMed

Farthing PM, Matear P, Cruchley AT (1990) The activation of Langerhans cells in oral lichen planus. J Oral Pathol Med 19(2):81–85CrossRefPubMed

Federico A, Morgillo F, Tuccillo C, Ciardiello F, Loguercio C (2007) Chronic inflammation and oxidative stress in human carcinogenesis. Int J Cancer 121(11):2381–2386CrossRefPubMed

Fitzpatrick SG, Hirsch SA, Gordon SC (2014) The malignant transformation of oral lichen planus and oral lichenoid lesions: a systematic review. J Am Dent Assoc 145(1):45–56CrossRefPubMed

Gavic L, Cigic L, Biocina LD, Gruden V, Gruden PJS (2014) The role of anxiety, depression, and psychological stress on the clinical status of recurrent aphthous stomatitis and oral lichen planus. J Oral Pathol Med 43(6):410–417CrossRefPubMed

Girardi C, Luz C, Cherubini K, de Figueiredo MA, Nunes ML, Salum FG (2011) Salivary cortisol and dehydroepiandrosterone (DHEA) levels, psychological factors in patients with oral lichen planus. Arch Oral Biol 56(9):864–868CrossRefPubMed

Hritcu L, Noumedem JA, Cioanca O, Hancianu M, Postu P, Mihasan M (2015) Anxiolytic and antidepressant profile of the methanolic extract of Piper nigrum fruits in beta-amyloid (1-42) rat model of Alzheimer’s disease. Behav Brain Funct 11:13CrossRefPubMedPubMedCentral

Huang W, Chen Z, Wang Q et al (2013) Piperine potentiates the antidepressant-like effect of trans-resveratrol: involvement of monoaminergic system. Metab Brain Dis 28(4):585–595CrossRefPubMed

Hwang YP, Yun HJ, Kim HG et al (2011) Suppression of phorbol-12-myristate-13-acetate-induced tumor cell invasion by piperine via the inhibition of PKCα/ERK1/2-dependent matrix metalloproteinase-9 expression. Toxicol Lett 203(1):9–19CrossRefPubMed

Ivanovski K, Nakova M, Warburton G et al (2005) Psychological profile in oral lichen planus. J Clin Periodontol 32(10):1034–1040CrossRefPubMed

Jungell P (1991) Oral lichen planus. A review. Int J Oral Maxillofac Surg. 20(3):129–135CrossRefPubMed

Kannan A, Huang W, Huang F, August A (2012) Signal transduction via the T cell antigen receptor in naïve and effector/memory T cells. Int J Biochem Cell Biol 44(12):2129–2134CrossRefPubMedPubMedCentral

Kawanishi S, Hiraku Y, Pinlaor S, Ma N (2006) Oxidative and nitrative DNA damage in animals and patients with inflammatory diseases in relation to inflammation-related carcinogenesis. Biol Chem 387(4):365–372CrossRefPubMed

Kesarwala AH, Krishna MC, Mitchell JB (2016) Oxidative stress in oral diseases. Oral Dis 22(1):9–18CrossRefPubMed

Khom S, Strommer B, Schöffmann A et al (2013) GABAA receptor modulation by piperine and a non-TRPV1 activating derivative. Biochem Pharmacol 85(12):1827–1836CrossRefPubMedPubMedCentral

Kim HG, Han EH, Jang WS et al (2012) Piperine inhibits PMA-induced cyclooxygenase-2 expression through downregulating NF-κB, C/EBP and AP-1 signaling pathways in murine macrophages. Food Chem Toxicol 50(7):2342–2348CrossRefPubMed

Koleva II, van Beek TA, Soffers AE, Dusemund B, Rietjens IM (2012) Alkaloids in the human food chain–natural occurrence and possible adverse effects. Mol Nutr Food Res 56(1):30–52CrossRefPubMed

Kong LD, Cheng CH, Tan RX (2004) Inhibition of MAO A and B by some plant-derived alkaloids, phenols and anthraquinones. J Ethnopharmacol 91(2–3):351–355CrossRefPubMed

Koray M, Dülger O, Ak G et al (2003) The evaluation of anxiety and salivary cortisol levels in patients with oral lichen planus. Oral Dis 9(6):298–301CrossRefPubMed

Kumar S, Singhal V, Roshan R, Sharma A, Rembhotkar GW, Ghosh B (2007) Piperine inhibits TNF-alpha induced adhesion of neutrophils to endothelial monolayer through suppression of NF-kappaB and IkappaB kinase activation. Eur J Pharmacol 575(1–3):177–186CrossRefPubMed

Lai LH, Fu QH, Liu Y et al (2012) Piperine suppresses tumor growth and metastasis in vitro and in vivo in a 4T1 murine breast cancer model. Acta Pharmacol Sin 33(4):523–530CrossRefPubMedPubMedCentral

Lee SA, Hong SS, Han XH et al (2005) Piperine from the fruits of Piper longum with inhibitory effect on monoamine oxidase and antidepressant-like activity. Chem Pharm Bull (Tokyo). 53(7):832–835CrossRefPubMed

Lee SH, Kim HY, Back SY, Han HK (2018) Piperine-mediated drug interactions and formulation strategy for piperine: recent advances and future perspectives. Expert Opin Drug Metab Toxicol. 14(1):43–57CrossRefPubMed

Li TJ, Cui J (2013) COX-2, MMP-7 expression in oral lichen planus and oral squamous cell carcinoma. Asian Pac J Trop Med. 6(8):640–643CrossRefPubMed

Li S, Wang C, Li W, Koike K, Nikaido T, Wang MW (2007a) Antidepressant-like effects of piperine and its derivative, antiepilepsirine. J Asian Nat Prod Res 9(3–5):421–430CrossRefPubMed

Li S, Wang C, Wang M, Li W, Matsumoto K, Tang Y (2007b) Antidepressant like effects of piperine in chronic mild stress treated mice and its possible mechanisms. Life Sci 80(15):1373–1381CrossRefPubMed

Liu Y, Yadev VR, Aggarwal BB, Nair MG (2010) Inhibitory effects of black pepper (Piper nigrum) extracts and compounds on human tumor cell proliferation, cyclooxygenase enzymes, lipid peroxidation and nuclear transcription factor-kappa-B. Nat Prod Commun 5(8):1253–1257CrossRefPubMed

Lodi G, Scully C, Carrozzo M, Griffiths M, Sugerman PB, Thongprasom K (2005) Current controversies in oral lichen planus: report of an international consensus meeting. Part 1. Viral infections and etiopathogenesis. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 100(1):40–51CrossRefPubMed

Lu R, Zhou G, Du G, Xu X, Yang J, Hu J (2011) Expression of T-bet and GATA-3 in peripheral blood mononuclear cells of patients with oral lichen planus. Arch Oral Biol 56(5):499–505CrossRefPubMed

Lu R, Zhang J, Sun W, Du G, Zhou G (2015) Inflammation-related cytokines in oral lichen planus: an overview. J Oral Pathol Med 44(1):1–14CrossRefPubMed

Lu Y, Liu J, Li H, Gu L (2016) Piperine ameliorates lipopolysaccharide-induced acute lung injury via modulating NF-κB signaling pathways. Inflammation. 39(1):303–308CrossRefPubMed

Lundqvist EN, Wahlin YB, Bergdahl M, Bergdahl J (2006) Psychological health in patients with genital and oral erosive lichen planus. J Eur Acad Dermatol Venereol 20(6):661–666CrossRefPubMed

Lysitsa S, Samson J, Gerber-Wicht C, Lang U, Lombardi T (2008) COX-2 expression in oral lichen planus. Dermatology 217(2):150–155CrossRefPubMed

Manayi A, Nabavi SM, Setzer WN, Jafari S (2017) Piperine as a potential anti-cancer agent: a review on preclinical studies. Curr Med Chem. https://doi.org/10.2174/0929867324666170523120656 CrossRef

Mao QQ, Xian YF, Ip SP, Che CT (2011) Involvement of serotonergic system in the antidepressant-like effect of piperine. Prog Neuropsychopharmacol Biol Psychiatry 35(4):1144–1147CrossRefPubMed

Mao QQ, Huang Z, Zhong XM, Xian YF, Ip SP (2014a) Brain-derived neurotrophic factor signalling mediates the antidepressant-like effect of piperine in chronically stressed mice. Behav Brain Res 261:140–145CrossRefPubMed

Mao QQ, Huang Z, Zhong XM, Xian YF, Ip SP (2014b) Piperine reverses chronic unpredictable mild stress-induced behavioral and biochemical alterations in rats. Cell Mol Neurobiol 34(3):403–408CrossRefPubMed

Maraskovsky E, Chen WF, Shortman K (1989) IL-2 and IFN-gamma are two necessary lymphokines in the development of cytolytic T cells. J Immunol. 143(4):1210–1214PubMed

Meghwal M, Goswami TK (2013) Piper nigrum and piperine: an update. Phytother Res. 27(8):1121–1130CrossRefPubMed

Mignogna MD, Fedele S, Lo RL, Lo ML, Bucci E (2004) Immune activation and chronic inflammation as the cause of malignancy in oral lichen planus: is there any evidence. Oral Oncol 40(2):120–130CrossRefPubMed

Misra S, Sharma K (2014) COX-2 signaling and cancer: new players in old arena. Curr Drug Targets 15(3):347–359CrossRefPubMed

Mittal R, Gupta RL (2000) In vitro antioxidant activity of piperine. Methods Find Exp Clin Pharmacol 22(5):271–274CrossRefPubMed

Myers LK, Kang AH, Postlethwaite AE et al (2000) The genetic ablation of cyclooxygenase 2 prevents the development of autoimmune arthritis. Arthritis Rheum 43(12):2687–2693CrossRefPubMed

Nadendla LK, Meduri V, Paramkusam G, Pachava KR (2014) Association of salivary cortisol and anxiety levels in lichen planus patients. J Clin Diagn Res. 8(12):ZC01–ZC03PubMedPubMedCentral

Nagler RM, Klein I, Zarzhevsky N, Drigues N, Reznick AZ (2002) Characterization of the differentiated antioxidant profile of human saliva. Free Radic Biol Med. 32(3):268–277CrossRefPubMed

Nogueira PA, Carneiro S, Ramos-e-Silva M (2015) Oral lichen planus: an update on its pathogenesis. Int J Dermatol 54(9):1005–1010CrossRefPubMed

Payeras MR, Cherubini K, Figueiredo MA, Salum FG (2013) Oral lichen planus: focus on etiopathogenesis. Arch Oral Biol 58(9):1057–1069CrossRefPubMed

Peng Q, Zhang J, Ye X, Zhou G (2017) Tumor-like microenvironment in oral lichen planus: evidence of malignant transformation. Expert Rev Clin Immunol. 13(6):635–643CrossRefPubMed

Pippi R, Patini R, Ghiciuc CM et al (2014) Diurnal trajectories of salivary cortisol, salivary α-amylase and psychological profiles in oral lichen planus patients. J Biol Regul Homeost Agents 28(1):147–156PubMed

Pippi R, Romeo U, Santoro M, Del VA, Scully C, Petti S (2016) Psychological disorders and oral lichen planus: matched case-control study and literature review. Oral Dis 22(3):226–234CrossRefPubMed

Pradeep CR, Kuttan G (2004) Piperine is a potent inhibitor of nuclear factor-kappaB (NF-kappaB), c-Fos, CREB, ATF-2 and proinflammatory cytokine gene expression in B16F-10 melanoma cells. Int Immunopharmacol 4(14):1795–1803CrossRefPubMed

Prolo P, Chiappelli F, Cajulis E et al (2002) Psychoneuroimmunology in oral biology and medicine: the model of oral lichen planus. Ann N Y Acad Sci 966:429–440CrossRefPubMed

Rauscher FM, Sanders RA, Watkins JB (2000) Effects of piperine on antioxidant pathways in tissues from normal and streptozotocin-induced diabetic rats. J Biochem Mol Toxicol 14(6):329–334CrossRefPubMed

Rekha VR, Sunil S, Rathy R (2017) Evaluation of oxidative stress markers in oral lichen planus. J Oral Maxillofac Pathol. 21(3):387–393CrossRefPubMedPubMedCentral

Rodgers G, Doucette CD, Soutar DA, Liwski RS, Hoskin DW (2016) Piperine impairs the migration and T cell-activating function of dendritic cells. Toxicol Lett 242:23–33CrossRefPubMed

Roopashree MR, Gondhalekar RV, Shashikanth MC, George J, Thippeswamy SH, Shukla A (2010) Pathogenesis of oral lichen planus–a review. J Oral Pathol Med 39(10):729–734CrossRefPubMed

Scrobotă I, Mocan T, Cătoi C, Bolfă P, Mureşan A, Băciuţ G (2011) Histopathological aspects and local implications of oxidative stress in patients with oral lichen planus. Rom J Morphol Embryol 52(4):1305–1309PubMed

Sezer E, Ozugurlu F, Ozyurt H, Sahin S, Etikan I (2007) Lipid peroxidation and antioxidant status in lichen planus. Clin Exp Dermatol 32(4):430–434CrossRefPubMed

Shah B, Ashok L, Sujatha GP (2009) Evaluation of salivary cortisol and psychological factors in patients with oral lichen planus. Indian J Dent Res. 20(3):288–292CrossRefPubMed

Shirzad A, Pouramir M, Seyedmajidi M, Jenabian N, Bijani A, Motallebnejad M (2014) Salivary total antioxidant capacity and lipid peroxidation in patients with erosive oral lichen planus. J Dent Res Dent Clin Dent Prospects. 8(1):35–39PubMedPubMedCentral

Singh P, Grover J, Byatnal AA, Guddattu V, Radhakrishnan R, Solomon MC (2017) Elucidating the role of Cyclooxygenase-2 in the pathogenesis of oral lichen planus—an immunohistochemical study with supportive histochemical analysis. J Oral Pathol Med 46(5):381–386CrossRefPubMed

Sloberg K, Jonsson R, Jontell M (1984) Assessment of Langerhans’ cells in oral lichen planus using monoclonal antibodies. J Oral Pathol 13(5):516–524CrossRefPubMed

Smith WL, Garavito RM, DeWitt DL (1996) Prostaglandin endoperoxide H synthases (cyclooxygenases)-1 and -2. J Biol Chem 271(52):33157–33160CrossRefPubMed

Srinivasan K (2007) Black pepper and its pungent principle-piperine: a review of diverse physiological effects. Crit Rev Food Sci Nutr 47(8):735–748CrossRefPubMed

Sugerman PB, Satterwhite K, Bigby M (2000) Autocytotoxic T-cell clones in lichen planus. Br J Dermatol 142(3):449–456CrossRefPubMed

Sugerman PB, Savage NW, Walsh LJ et al (2002) The pathogenesis of oral lichen planus. Crit Rev Oral Biol Med 13(4):350–365CrossRefPubMed

Suzuki J, Ogawa M, Futamatsu H, Kosuge H, Tanaka H, Isobe M (2006) A cyclooxygenase-2 inhibitor alters Th1/Th2 cytokine balance and suppresses autoimmune myocarditis in rats. J Mol Cell Cardiol 40(5):688–695CrossRefPubMed

Tadakamadla J, Kumar S, Lalloo R, Johnson NW (2017) Qualitative analysis of the impact of oral potentially malignant disorders on daily life activities. PLoS One 12(4):e0175531CrossRefPubMedPubMedCentral

Tvarijonaviciute A, Aznar-Cayuela C, Rubio CP, Ceron JJ, López-Jornet P (2017) Evaluation of salivary oxidate stress biomarkers, nitric oxide and C-reactive protein in patients with oral lichen planus and burning mouth syndrome. J Oral Pathol Med 46(5):387–392CrossRefPubMed

Uma PK, Geervani P, Eggum BO (1993) Common Indian spices: nutrient composition, consumption and contribution to dietary value. Plant Foods Hum Nutr 44(2):137–148CrossRef

Upadhyay RB, Carnelio S, Shenoy RP, Gyawali P, Mukherjee M (2010) Oxidative stress and antioxidant defense in oral lichen planus and oral lichenoid reaction. Scand J Clin Lab Invest 70(4):225–228CrossRefPubMed

Upadhyay J, Upadhyay RB, Agrawal P, Jaitley S, Shekhar R (2013) Langerhans cells and their role in oral mucosal diseases. N Am J Med Sci. 5(9):505–514CrossRefPubMedPubMedCentral

Vaibhav K, Shrivastava P, Javed H et al (2012) Piperine suppresses cerebral ischemia-reperfusion-induced inflammation through the repression of COX-2, NOS-2, and NF-κB in middle cerebral artery occlusion rat model. Mol Cell Biochem 367(1–2):73–84CrossRefPubMed

Vallejo MJ, Huerta G, Cerero R, Seoane JM (2001) Anxiety and depression as risk factors for oral lichen planus. Dermatology 203(4):303–307CrossRefPubMed

van der Waal I (2009) Potentially malignant disorders of the oral and oropharyngeal mucosa; terminology, classification and present concepts of management. Oral Oncol 45(4–5):317–323CrossRef

Vardell E (2015) Natural Medicines: a Complementary and Alternative Medicines Tool Combining Natural Standard and the Natural Medicines Comprehensive Database. Med Ref Serv Q. 34(4):461–470CrossRefPubMed

Verma A, Kushwaha HN, Srivastava AK et al (2017) Piperine attenuates UV-R induced cell damage in human keratinocytes via NF-kB, Bax/Bcl-2 pathway: an application for photoprotection. J Photochem Photobiol, B 172:139–148CrossRef

Vijayakumar RS, Surya D, Nalini N (2004) Antioxidant efficacy of black pepper (Piper nigrum L.) and piperine in rats with high fat diet induced oxidative stress. Redox Rep. 9(2):105–110CrossRefPubMed

Vlková B, Stanko P, Minárik G et al (2012) Salivary markers of oxidative stress in patients with oral premalignant lesions. Arch Oral Biol 57(12):1651–1656CrossRefPubMed

Wattanathorn J, Chonpathompikunlert P, Muchimapura S, Priprem A, Tankamnerdthai O (2008) Piperine, the potential functional food for mood and cognitive disorders. Food Chem Toxicol 46(9):3106–3110CrossRefPubMed

Ying X, Chen X, Cheng S, Shen Y, Peng L, Xu HZ (2013a) Piperine inhibits IL-β induced expression of inflammatory mediators in human osteoarthritis chondrocyte. Int Immunopharmacol 17(2):293–299CrossRefPubMed

Ying X, Yu K, Chen X et al (2013b) Piperine inhibits LPS induced expression of inflammatory mediators in RAW 264.7 cells. Cell Immunol. 285(1–2):49–54CrossRefPubMed

Zaugg J, Baburin I, Strommer B, Kim HJ, Hering S, Hamburger M (2010) HPLC-based activity profiling: discovery of piperine as a positive GABA(A) receptor modulator targeting a benzodiazepine-independent binding site. J Nat Prod 73(2):185–191CrossRefPubMedPubMedCentral

Zhai WJ, Zhang ZB, Xu NN et al (2016) Piperine plays an anti-inflammatory role in staphylococcus aureus endometritis by inhibiting activation of NF-κB and MAPK pathways in mice. Evid Based Complement Alternat Med. 2016:8597208PubMedPubMedCentral

Zhang L, Bertucci AM, Smith KA, Xu L, Datta SK (2007) Hyperexpression of cyclooxygenase 2 in the lupus immune system and effect of cyclooxygenase 2 inhibitor diet therapy in a murine model of systemic lupus erythematosus. Arthritis Rheum 56(12):4132–4141CrossRefPubMed

Zhang J, Zhu X, Li H et al (2015) Piperine inhibits proliferation of human osteosarcoma cells via G2/M phase arrest and metastasis by suppressing MMP-2/-9 expression. Int Immunopharmacol 24(1):50–58CrossRefPubMed

Zhou XJ, Sugerman PB, Savage NW, Walsh LJ (2001) Matrix metalloproteinases and their inhibitors in oral lichen planus. J Cutan Pathol 28(2):72–82CrossRefPubMed

Zhou G, Xia K, Du GF et al (2009) Activation of nuclear factor-kappa B correlates with tumor necrosis factor-alpha in oral lichen planus: a clinicopathologic study in atrophic-erosive and reticular form. J Oral Pathol Med 38(7):559–564CrossRefPubMed

Zhou G, Zhang J, Ren XW, Hu JY, Du GF, Xu XY (2012) Increased B7-H1 expression on peripheral blood T cells in oral lichen planus correlated with disease severity. J Clin Immunol 32(4):794–801CrossRefPubMed

Titel: Black pepper and its bioactive constituent piperine: promising therapeutic strategies for oral lichen planus
verfasst von: Jing-Ya Yang
Jing Zhang
Gang Zhou
Publikationsdatum: 20.10.2018
Verlag: Springer International Publishing
Erschienen in: Inflammopharmacology / Ausgabe 1/2019
Print ISSN: 0925-4692
Elektronische ISSN: 1568-5608
DOI: https://doi.org/10.1007/s10787-018-0540-7

Springer Medizin

Abstract

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

Weitere Artikel der Ausgabe 1/2019

Nimbolide ameliorates fibrosis and inflammation in experimental murine model of bleomycin-induced scleroderma

Dr. Stewart Sanders Adams (16 April 1923 to 30 January 2019)

SB203580 attenuates acute lung injury and inflammation in rats with acute pancreatitis in pregnancy

Anti-inflammatory mechanisms of cannabinoids: an immunometabolic perspective

Antineoplastic influence of nimesulide in chemically induced hepatocellular carcinoma by inhibition of DNA synthesis

Preventive treatment with dizocilpine attenuates oedema in a carrageenan model of inflammation: the interaction of glutamatergic and nitrergic signaling