Skip to main content
Erschienen in: Current Bladder Dysfunction Reports 4/2023

30.09.2023

Bladder Stones in Pediatric Patients with Bladder Dysfunction: a Review of Pathophysiology and Management

verfasst von: Christopher J. Staniorski, Esther K. Liu, Rajeev Chaudhry

Erschienen in: Current Bladder Dysfunction Reports | Ausgabe 4/2023

Einloggen, um Zugang zu erhalten

Abstract

Purpose of Review

Bladder stones are a prevalent problem in children with neurogenic bladder that impact quality of life and subject patients to multiple procedures. The physiology of bladder dysfunction as well as medical interventions employed to efficiently empty the bladder and lower bladder pressures contribute to the formation of stones. In this paper, we aim to review the literature concerning bladder stone pathophysiology, prevention, surveillance, and surgical management for pediatric patients suffering from neurogenic bladder.

Recent Findings

Historical data has provided the basis of our understanding of pathophysiology and formation of bladder stones in this population. Various prevention strategies seek to counteract the limitations of catheterization and augmentation to limit the likelihood of stone formation. More recent literature has evaluated strategies to limit the morbidity of recurrent stone procedures with minimally invasive techniques.

Summary

Bladder calculi are a common problem in the pediatric neurogenic population due to alterations in physiology and interventions. Current work in prevention and minimally invasive stone removal techniques will inform our practice for these patients going forward.
Literatur
1.
Zurück zum Zitat •• Schlomer BJ, Copp HL. Cumulative incidence of outcomes and urologic procedures after augmentation cystoplasty. J Pediatr Urol. 2014;10:1043–50. This retrospective analysis of the Pediatric Health Information System includes over 2800 patients undergoing bladder augment and characterizes rates of bladder stone formation and risk factors.CrossRefPubMedPubMedCentral •• Schlomer BJ, Copp HL. Cumulative incidence of outcomes and urologic procedures after augmentation cystoplasty. J Pediatr Urol. 2014;10:1043–50. This retrospective analysis of the Pediatric Health Information System includes over 2800 patients undergoing bladder augment and characterizes rates of bladder stone formation and risk factors.CrossRefPubMedPubMedCentral
2.
Zurück zum Zitat Douenias R, Rich M, Badlani G, Mazor D, Smith A. Predisposing factors in bladder calculi: review of 100 cases. Urology. 1991;37:240–3.CrossRefPubMed Douenias R, Rich M, Badlani G, Mazor D, Smith A. Predisposing factors in bladder calculi: review of 100 cases. Urology. 1991;37:240–3.CrossRefPubMed
3.
Zurück zum Zitat Weld KJ, Dmochowski RR. Effect of bladder management on urological complications in spinal cord injured patients. J Urol. 2000;163:768–72.CrossRefPubMed Weld KJ, Dmochowski RR. Effect of bladder management on urological complications in spinal cord injured patients. J Urol. 2000;163:768–72.CrossRefPubMed
4.
Zurück zum Zitat Barroso U Jr, Jednak R, Fleming P, Barthold J, Gonzalez R. Bladder calculi in children who perform clean intermittent catheterization. BJU Int. 2000;85:879–84.CrossRefPubMed Barroso U Jr, Jednak R, Fleming P, Barthold J, Gonzalez R. Bladder calculi in children who perform clean intermittent catheterization. BJU Int. 2000;85:879–84.CrossRefPubMed
5.
Zurück zum Zitat •• Berkowitz J, North A, Tripp R, Gearhart JP, Lakshmanan Y. Mitrofanoff continent catheterizable conduits: top down or bottom up? J Pediatr Urol. 2009;5:122–5. This reference demonstrates the importance of a posteriorly placed catheterizable channel.CrossRefPubMed •• Berkowitz J, North A, Tripp R, Gearhart JP, Lakshmanan Y. Mitrofanoff continent catheterizable conduits: top down or bottom up? J Pediatr Urol. 2009;5:122–5. This reference demonstrates the importance of a posteriorly placed catheterizable channel.CrossRefPubMed
6.
Zurück zum Zitat Djojodimedjo T, Soebadi DM. Escherichia coli infection induces mucosal damage and expression of proteins promoting urinary stone formation. Urolithiasis. 2013;41:295–301.CrossRefPubMed Djojodimedjo T, Soebadi DM. Escherichia coli infection induces mucosal damage and expression of proteins promoting urinary stone formation. Urolithiasis. 2013;41:295–301.CrossRefPubMed
7.
Zurück zum Zitat DeFoor W, Minevich E, Reddy P, Sekhon D, Polsky E, Wacksman J, et al. Bladder calculi after augmentation cystoplasty: risk factors and prevention strategies. J Urol. 2004;172:1964–6.CrossRefPubMed DeFoor W, Minevich E, Reddy P, Sekhon D, Polsky E, Wacksman J, et al. Bladder calculi after augmentation cystoplasty: risk factors and prevention strategies. J Urol. 2004;172:1964–6.CrossRefPubMed
8.
Zurück zum Zitat Marei MM, Jackson R, Keene DJ. Intravesical gentamicin instillation for the treatment and prevention of urinary tract infections in complex paediatric urology patients: evidence for safety and efficacy. J Pediatr Urol. 2021;17:65-e1.CrossRef Marei MM, Jackson R, Keene DJ. Intravesical gentamicin instillation for the treatment and prevention of urinary tract infections in complex paediatric urology patients: evidence for safety and efficacy. J Pediatr Urol. 2021;17:65-e1.CrossRef
9.
Zurück zum Zitat Kronner KM, Casale AJ, Cain MP, Zerin MJ, Keating MA, Rink RC. Bladder calculi in the pediatric augmented bladder. J Urol. 1998;160:1096–8.CrossRefPubMed Kronner KM, Casale AJ, Cain MP, Zerin MJ, Keating MA, Rink RC. Bladder calculi in the pediatric augmented bladder. J Urol. 1998;160:1096–8.CrossRefPubMed
10.
Zurück zum Zitat Hayashi Y, Nishimura E, Shimizu S, Miyano G, Okawada M, Nagae I, et al. Sigmoidocolocystoplasty for neurogenic bladder reviewed after 20 years. J Pediatr Surg. 2017;52:2070–3.CrossRefPubMed Hayashi Y, Nishimura E, Shimizu S, Miyano G, Okawada M, Nagae I, et al. Sigmoidocolocystoplasty for neurogenic bladder reviewed after 20 years. J Pediatr Surg. 2017;52:2070–3.CrossRefPubMed
11.
Zurück zum Zitat • Szymanski KM, Misseri R, Whittam B, Lingeman JE, Amstutz S, Ring JD, et al. Bladder stones after bladder augmentation are not what they seem. J Pediatr Urol. 2016;12:98-e1. This study characterizes bladder stone composition in neurogenic augmented bladders.CrossRef • Szymanski KM, Misseri R, Whittam B, Lingeman JE, Amstutz S, Ring JD, et al. Bladder stones after bladder augmentation are not what they seem. J Pediatr Urol. 2016;12:98-e1. This study characterizes bladder stone composition in neurogenic augmented bladders.CrossRef
12.
Zurück zum Zitat Khoury AE, Salomon M, Doche R, Soboh F, Ackerley C, Jayanthi R, et al. Stone formation after augmentation cystoplasty: the role of intestinal mucus. J Urol. 1997;158:1133–7.CrossRefPubMed Khoury AE, Salomon M, Doche R, Soboh F, Ackerley C, Jayanthi R, et al. Stone formation after augmentation cystoplasty: the role of intestinal mucus. J Urol. 1997;158:1133–7.CrossRefPubMed
13.
Zurück zum Zitat van den Heijkant M, Haider N, Taylor C, Subramaniam R. Efficacy of bladder irrigation and surveillance program in prevention of urinary tract infections and bladder calculi in children with an ileocystoplasty and bladder neck repair. Pediatr Surg Int. 2011;27:781–5.CrossRefPubMed van den Heijkant M, Haider N, Taylor C, Subramaniam R. Efficacy of bladder irrigation and surveillance program in prevention of urinary tract infections and bladder calculi in children with an ileocystoplasty and bladder neck repair. Pediatr Surg Int. 2011;27:781–5.CrossRefPubMed
14.
Zurück zum Zitat •• Szymanski KM, Misseri R, Whittam B, Amstutz S, Kaefer M, Rink RC, et al. Cutting for stone in augmented bladders—what is the risk of recurrence and is it impacted by treatment modality? J Urol. 2014;191:1375–80. This study established similar rates of recurrence in endoscopic compared to open bladder stone management.CrossRefPubMed •• Szymanski KM, Misseri R, Whittam B, Amstutz S, Kaefer M, Rink RC, et al. Cutting for stone in augmented bladders—what is the risk of recurrence and is it impacted by treatment modality? J Urol. 2014;191:1375–80. This study established similar rates of recurrence in endoscopic compared to open bladder stone management.CrossRefPubMed
15.
Zurück zum Zitat Joseph DB, Baum MA, Tanaka ST, Frimberger DC, Misseri R, Khavari R, et al. Urologic guidelines for the care and management of people with spina bifida. J Pediatr Rehabil Med. 2020;13:479–89.CrossRefPubMedPubMedCentral Joseph DB, Baum MA, Tanaka ST, Frimberger DC, Misseri R, Khavari R, et al. Urologic guidelines for the care and management of people with spina bifida. J Pediatr Rehabil Med. 2020;13:479–89.CrossRefPubMedPubMedCentral
16.
Zurück zum Zitat Husmann DA. Long-term complications following bladder augmentations in patients with spina bifida: bladder calculi, perforation of the augmented bladder and upper tract deterioration. Transl Androl Urol. 2016;5:3.PubMedPubMedCentral Husmann DA. Long-term complications following bladder augmentations in patients with spina bifida: bladder calculi, perforation of the augmented bladder and upper tract deterioration. Transl Androl Urol. 2016;5:3.PubMedPubMedCentral
17.
Zurück zum Zitat Roberts WW, Gearhart JP, Mathews RI. Time to recurrent stone formation in patients with bladder or continent reservoir reconstruction: fragmentation versus intact extraction. J Urol. 2004;172:1706–9.CrossRefPubMed Roberts WW, Gearhart JP, Mathews RI. Time to recurrent stone formation in patients with bladder or continent reservoir reconstruction: fragmentation versus intact extraction. J Urol. 2004;172:1706–9.CrossRefPubMed
18.
Zurück zum Zitat Van Savage JG, Khoury AE, McLorie GA, Churchill BM. Percutaneous vacuum vesicolithotomy under direct vision: a new technique. J Urol. 1996;156:706–8.CrossRefPubMed Van Savage JG, Khoury AE, McLorie GA, Churchill BM. Percutaneous vacuum vesicolithotomy under direct vision: a new technique. J Urol. 1996;156:706–8.CrossRefPubMed
19.
Zurück zum Zitat • Rhee AC, Cain MP. Percutaneous cystolithotomy in the pediatric neuropathic bladder with laparoscopic trocar access: a modified approach useful for the augmented and native bladder, and continent urinary reservoir. J Pediatr Urol. 2013;9:289–92. Introduced a popular method of percutaneous access for stone management.CrossRefPubMed • Rhee AC, Cain MP. Percutaneous cystolithotomy in the pediatric neuropathic bladder with laparoscopic trocar access: a modified approach useful for the augmented and native bladder, and continent urinary reservoir. J Pediatr Urol. 2013;9:289–92. Introduced a popular method of percutaneous access for stone management.CrossRefPubMed
20.
Zurück zum Zitat • Esposito C, Autorino G, Masieri L, Castagnetti M, Del Conte F, Coppola V, et al. Minimally invasive management of bladder stones in children. Front Pediatr. 2021;8:618756. This reference includes a description and initial results of the robotic cystolithotomy technique.CrossRefPubMedPubMedCentral • Esposito C, Autorino G, Masieri L, Castagnetti M, Del Conte F, Coppola V, et al. Minimally invasive management of bladder stones in children. Front Pediatr. 2021;8:618756. This reference includes a description and initial results of the robotic cystolithotomy technique.CrossRefPubMedPubMedCentral
Metadaten
Titel
Bladder Stones in Pediatric Patients with Bladder Dysfunction: a Review of Pathophysiology and Management
verfasst von
Christopher J. Staniorski
Esther K. Liu
Rajeev Chaudhry
Publikationsdatum
30.09.2023
Verlag
Springer US
Erschienen in
Current Bladder Dysfunction Reports / Ausgabe 4/2023
Print ISSN: 1931-7212
Elektronische ISSN: 1931-7220
DOI
https://doi.org/10.1007/s11884-023-00714-6

Weitere Artikel der Ausgabe 4/2023

Current Bladder Dysfunction Reports 4/2023 Zur Ausgabe

Neue S3-Leitlinie zur unkomplizierten Zystitis: Auf Antibiotika verzichten?

15.05.2024 Harnwegsinfektionen Nachrichten

Welche Antibiotika darf man bei unkomplizierter Zystitis verwenden und wovon sollte man die Finger lassen? Welche pflanzlichen Präparate können helfen? Was taugt der zugelassene Impfstoff? Antworten vom Koordinator der frisch überarbeiteten S3-Leitlinie, Prof. Florian Wagenlehner.

Viel pflanzliche Nahrung, seltener Prostata-Ca.-Progression

12.05.2024 Prostatakarzinom Nachrichten

Ein hoher Anteil pflanzlicher Nahrung trägt möglicherweise dazu bei, das Progressionsrisiko von Männern mit Prostatakarzinomen zu senken. In einer US-Studie war das Risiko bei ausgeprägter pflanzlicher Ernährung in etwa halbiert.

Darf man die Behandlung eines Neonazis ablehnen?

08.05.2024 Gesellschaft Nachrichten

In einer Leseranfrage in der Zeitschrift Journal of the American Academy of Dermatology möchte ein anonymer Dermatologe bzw. eine anonyme Dermatologin wissen, ob er oder sie einen Patienten behandeln muss, der eine rassistische Tätowierung trägt.

Hypertherme Chemotherapie bietet Chance auf Blasenerhalt

07.05.2024 Harnblasenkarzinom Nachrichten

Eine hypertherme intravesikale Chemotherapie mit Mitomycin kann für Patienten mit hochriskantem nicht muskelinvasivem Blasenkrebs eine Alternative zur radikalen Zystektomie darstellen. Kölner Urologen berichten über ihre Erfahrungen.

Update Urologie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.