Erschienen in:
01.12.2000 | Paper Report
BLyS in humoral immunity
verfasst von:
Chaim Putterman
Erschienen in:
Arthritis Research & Therapy
|
Ausgabe 1/2000
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Excerpt
The identification and biological actions of a newly described TNF homologue alternatively known as BLyS, BAFF and zTNF4 has generated much interest among immunologists. In previous paper reports, I discussed recent articles describing autoimmune features in BAFF-transgenic mice. A possible role for this molecule in autoimmunity could also be inferred by the presence of high levels of this mediator in murine models of lupus, and a moderate therapeutic effect of the soluble BAFF receptor TACI (transmembrane activator and CAML-interactor) in murine lupus. To study the molecular effects of the molecule and define a role for BLyS in humoral immunity. …