Erschienen in:
01.12.2000 | Paper Report
Identification of a B cell activation specific enzyme
verfasst von:
Thomas Dorner
Erschienen in:
Arthritis Research & Therapy
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Ausgabe 1/2000
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Excerpt
Although recombination of V genes is well characterized, other fundamental processes further diversifying the Ig repertoire, such as class switching and in particular somatic hypermutation still remain enigmatic. Notably, these two types of genetic alteration in the immune system take place in a highly specialized microenvironment called the germinal center resulting in the generation of high-affinity antibodies for a given antigen during affinity maturation. However, the involved enzymes or enzymatic complexes are not identified to date. Previously, cDNA subtraction between stimulated and nonstimulated CH12F3-2 cells identified a novel member of the RNA editing cytidine deaminase family, activation-induced cytidine deaminase (AID) which was specifically expressed in germinal center B cells (see Additional information). …