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Archives of Gynecology and Obstetrics
Erschienen in: Archives of Gynecology and Obstetrics 4/2012

01.04.2012 | General Gynecology

Bone mineral density is not associated with homocysteine level, folate and vitamin B12 status

verfasst von: Ivana Rumbak, Vesna Žižić, Lea Sokolić, Selma Cvijetić, Romana Kajfež, Irena Colić Barić

Erschienen in: Archives of Gynecology and Obstetrics | Ausgabe 4/2012

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Abstract

Purpose

The relationship of homocysteine (Hcy), folate and vitamin B12 with bone mineral density (BMD) has been studied in various populations but still remains inconsistent. The aim of this study was to test whether the levels of plasma Hcy, serum and red blood cell folate, and vitamin B12 are related to BMD in the group of adult Croatian women regardless of menopausal status. Some other lifestyle and dietary habits like smoking, physical activity and alcohol consumption were also observed in relation to BMD.

Methods

One-hundred and thirty-one women, aged 45–65 years participated in the study. BMD was measured using dual-energy X-ray absorptiometry. Measurements were made at the lumbar spine (L1–L4), left femoral neck, total femur and distal third of the radius. Plasma total Hcy, serum folate, red blood cell folate and serum vitamin B12 were also determined.

Results

No significant correlations were found between Hcy, folate and/or vitamin B12 and BMD of measured skeletal sites. Body mass index (BMI), age, as well as alcohol consumption were significantly correlated with BMD at the lumbar spine. Positive significant correlation was found between BMI and BMD at the femoral neck and total femur while BMI and age were significant predictors of BMD at the radius (multiple regression analysis). When only postmenopausal women were included, significant predictors of BMD at the lumbar spine were age, BMI, alcohol consumption and intake of hormone replacement therapy.

Conclusion

Results of this study suggest that Hcy, folate or vitamin B12 levels were not related to BMD in population of healthy Croatian women aged 45–65. In the group of postmenopausal Croatian women, beside BMI and age, alcohol consumption was significant positive predictor of BMD at the lumbar spine.
Literatur
1.
McLean RR, Jacques PF, Selhub J, Tucker KL, Samelson EJ, Broe KE, Hannan MT, Cupples LA, Kiel DP (2004) Homocysteine as a predictive factor for hip fracture in older persons. N Engl J Med 350:2042–2049PubMedCrossRef
2.
3.
Mudd SH, Skovby F, Levy HL, Pettigrew KD, Wilcken B, Pyeritz RE, Wilcken B, Pyeritz RE, Andria G, Boers GHJ, Bromberg IL, Cerone R, Fowler B, Grobe H, Schmidt H, Schweitzer L (1985) The natural history of homocystinuria due to cystathionine beta-synthase deficiency. Am J Hum Genet 37:1–31PubMed
4.
Miyao M, Morita H, Hosoi T, Kurihara H, Inoue S, Hoshino S, Shiraki M, Yazaki Y, Ouchi Y (2000) Association of methylene tetrahydrofolate-reductase (MTHFR) polymorphism with bone mineral density in postmenopausal Japanese women. Calcif Tissue Int 66:190–194PubMedCrossRef
5.
Jorgensen HL, Madsen JS, Madsen B, Saleh MMA, Abrahamsem B, Fenger M, Lauritzen JB (2002) Association of a common allelic polymorphism (C677T) in the methylene tetrahydrofolate reductase gene with a reduced risk of osteoporotic fractures: a case control study in Danish postmenopausal women. Calcif Tissue Int 71:386–392PubMedCrossRef
6.
Abrahamsen B, Madsen JS, Tofteng CL, Stilgren L, Bladbjerg EM, Kristensen SR, Brixen K, Mosekilde L (2003) A common methylenetetrahydrofolate reductase (C677T) polymorphism is associated with low bone mineral density and increased fracture incidence after menopause: longitudinal data from the Danish Osteoporosis Prevention Study. J Bone Miner Res 18:723–729PubMedCrossRef
7.
van Meurs JB, Dhonukshe-Rutten RA, Pluijm SM, van der Klift M, de Jonge R, Lindemans J, de Groot LC, Hofman A, Witteman JC, van Leeuwen JP, Breteler MM, Lips P, Pols HA, Uitterlinden AG (2004) Homocysteine levels and the risk of osteoporotic fracture. N Engl J Med 350:2033–2041PubMedCrossRef
8.
McLean RR, Jacques PF, Selhub J, Tucker KL, Samelson EJ, Broe KE, Hannan MT, Cupples LA, Kiel DP (2004) Homocysteine as a predictive factor for hip fracture in older persons. N Engl J Med 350:2042–2049PubMedCrossRef
9.
Elshorbagy AK, Gjesdal CG, Nurk E, Tell GS, Ueland PM, Nygård O, Tverdal A, Vollset SE, Smith AD, Refsum H (2009) Cysteine, homocysteine and bone mineral density: a role for body composition? Bone 44(5):954–958PubMedCrossRef
10.
Golbahar J, Aminzadeh MA, Hamidi SA, Omrani GR (2005) Association of red blood cell 5-methyltetrahydrfoate folate with bone mineral density in postmenopausal Iranian women. Osteoporos Int 16:1894–1898PubMedCrossRef
11.
Tucker KL, Hannan MT, Qiao N, Jacques PF, Selhub J, Cupples LA, Kiel DP (2005) Low plasma vitamin B12 is associated with lower BMD: The Framingham Osteoporosis Study. J Bone Miner Res 20:152–158PubMedCrossRef
12.
Dhonukshe-Rutten RA, van Dusseldorp M, Schneede J, de Groot LC, van Staveren WA (2005) Low bone mineral density and bone mineral content are associated with low cobalamin status in adolescents. Eur J Nutr 44(6):341–347PubMedCrossRef
13.
Dhonukshe-Rutten RA, Lips M, de Jong N, Chin A, Paw MJ, Hiddink GJ, van Dusseldorp M, De Groot LC, van Staveren WA (2003) Vitamin B12 status is associated with bone mineral content and bone mineral density in frail elderly women but not in men. J Nutr 133(3):801–807PubMed
14.
Bozkurt N, Erdem M, Yilmaz E, Erdem A, Biri A, Kubatova A, Bozkurt M (2009) The relationship of homocysteine, B12 and folic acid with the bone mineral density of the femur and lumbar spine in Turkish postmenopausal women. Arch Gynecol Obstet 280:381–387PubMedCrossRef
15.
Morris MS, Jacques PF, Selhub J (2005) Relation between homocysteine and B-vitamin status indicators and bone mineral density in older Americans. Bone 37:234–242PubMedCrossRef
16.
Gjesdal CG, Vollset SE, Ueland PM, Refsum H, Drevon CA, Gjessing HK, Tell GS (2006) Plasma total homocysteine level and bone mineral density: The Hordaland homocysteine study. Arch Intern Med 166(1):88–94PubMedCrossRef
17.
Golbahar J, Hamidi A, Aminzadeh MA, Omrani GR (2004) Association of plasma folate, plasma total homocysteine, but not methylenetetrahydrofolate reductase C667T polymorphism, with bone mineral density in postmenopausal Iranian women: a cross-sectional study. Bone 35:760–765PubMedCrossRef
18.
Cagnacci A, Baldassari F, Rivolta G, Arangino S, Volpe A (2003) Relation of homocysteine, folate and vitamin B12 to bone mineral density of postmenopausal women. Bone 33:956–999PubMedCrossRef
19.
Baines M, Kredan M-B, Usher J, Davison A, Higgins G, Taylor W, West C, Fraser WD, Ranganath LR (2007) The association of homocysteine and its determinants MTHFR genotype, folate, vitamin B12 and vitamin B6 with bone mineral density in postmenopausal British women. Bone 40(3):730–736PubMedCrossRef
20.
Haliloglu B, Aksungar FB, Ilter E, Peker H, Akin FT, Ozekici U (2010) Relationship between bone mineral density, bone turnover markers and homocysteine, folate and vitamin B12 levels in postmenopausal women. Arch Gynecol Obstet 281(4):663–668PubMedCrossRef
21.
Herrmann M, Kraenzlin M, Pape G, Sand-Hill M, Herrmann W (2005) Relation between homocysteine and biochemical bone turnover markers and bone mineral density in peri- and post-menopausal women. Clin Chem Lab Med 43(10):1118–1123PubMedCrossRef
22.
Bruschi F, Daguati R, Parazzini F, Dal Pino D, Fiore V, Di Pace R, Melotti D, Moroni S, Maffioletti C, Rossi M, Crosignani PG (2005) Age, menopausal status and homocysteine levels in women around menopause. Eur J Obstet Gynecol Reprod Biol 120(2):195–197PubMedCrossRef
23.
Callaway CW, Chumlea WC, Bouchard C, Himes JH, Lohman TG, Martin AD, Mitchell CD, Mueller WH, Roche AF, Seefeldt VD (1988) Circumferences. In: Lohman TG, Roche AF, Martorell R (eds) Anthropometric standardization reference manual. Human Kinetics Books, Champaign, p 39
24.
Prodigy Safety Information and Technical Specifications. Document version:9/00A, GE Lunar Corporation, USA
25.
26.
Ouzzif Z, Oumghar K, Sbai K, Mounach A, Derouiche EM, El Maghraoui A (2010) Relation of plasma total homocysteine, folate and vitamin B12 levels to bone mineral density in Moroccan healthy postmenopausal women. Rheumatol Int (epub ahead of print)
27.
Bucciarelli P, MartiniG MartinelliI, Ceccarelli E, Gennari L, Bader R, Valenti R, Franci B, Nuti R, Mannucci P (2010) The relationship between plasma homocysteine levels and bone mineral density in post-menopausal women. Eur J Intern Med 21:301–305PubMedCrossRef
28.
Burger H, De Laet CE, van Daele PL, Weel AE, Witteman JC, Hofman A, Pols HA (1998) Risk factors for increased bone loss in an elderly population: the Rotterdam Study. Am J Epidemiol 147:871–879PubMed
29.
Dargent-Molina P, Poitiers F, Breart G (2000) In elderly women weight is the best predictor of a very low bone mineral density: evidence from the EPIDOS study. Osteoporos Int 11:881–888PubMedCrossRef
30.
van der Voort DJ, Geusens PP, Dinant GJ (2001) Risk factors for osteoporosis related to their outcome: fractures. Osteoporos Int 12:630–638PubMedCrossRef
31.
Cummings SR, Nevitt MC, Browner WS, Stone K, Fox KM, Ensrud KE, Cauley J, Black D, Vogt TM (1995) Risk factors for hip fracture in white women. N Engl J Med 332:767–773PubMedCrossRef
32.
Farahmand BY, Michaelsson K, Baron JA, Persson PG, Ljunghall S (2000) Body size and hip fracture risk. Swedish Hip Fracture Study Group. Epidemiology 11:214–219PubMedCrossRef
33.
Ilich JZ, Cvijetic S, Colic Baric I, Cecic I, Saric M, Crncevic-Orlic Z, Blanusa M, Korsic M (2009) Nutrition and lifestyle in relation to bone health and body weight in Croatian postmenopausal women. Int J Food Sci Nutr 60:319–332PubMedCrossRef
Metadaten
Titel
Bone mineral density is not associated with homocysteine level, folate and vitamin B12 status
verfasst von
Ivana Rumbak
Vesna Žižić
Lea Sokolić
Selma Cvijetić
Romana Kajfež
Irena Colić Barić
Publikationsdatum
01.04.2012
Verlag
Springer-Verlag
Erschienen in
Archives of Gynecology and Obstetrics / Ausgabe 4/2012
Print ISSN: 0932-0067
Elektronische ISSN: 1432-0711
DOI
https://doi.org/10.1007/s00404-011-2079-3

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