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Current HIV/AIDS Reports
Erschienen in: Current HIV/AIDS Reports 5/2022

20.06.2022 | Co-infections and Comorbidity (D Bhattacharya, Section Editor)

Bone Quality in Relation to HIV and Antiretroviral Drugs

verfasst von: Arnold Z. Olali, Kelsey A. Carpenter, Maria Myers, Anjali Sharma, Michael T. Yin, Lena Al-Harthi, Ryan D. Ross

Erschienen in: Current HIV/AIDS Reports | Ausgabe 5/2022

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Abstract

Purpose of Review

People living with HIV (PLWH) are at an increased risk for osteoporosis, a disease defined by the loss of bone mineral density (BMD) and deterioration of bone quality, both of which independently contribute to an increased risk of skeletal fractures. While there is an emerging body of literature focusing on the factors that contribute to BMD loss in PLWH, the contribution of these factors to bone quality changes are less understood. The current review summarizes and critically reviews the data describing the effects of HIV, HIV disease-related factors, and antiretroviral drugs (ARVs) on bone quality.

Recent Findings

The increased availability of high-resolution peripheral quantitative computed tomography has confirmed that both HIV infection and ARVs negatively affect bone architecture. There is considerably less data on their effects on bone remodeling or the composition of bone matrix. Whether changes in bone quality independently predict fracture risk, as seen in HIV-uninfected populations, is largely unknown.

Summary

The available data suggests that bone quality deterioration occurs in PLWH. Future studies are needed to define which factors, viral or ARVs, contribute to loss of bone quality and which bone quality factors are most associated with increased fracture risk.
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Metadaten
Titel
Bone Quality in Relation to HIV and Antiretroviral Drugs
verfasst von
Arnold Z. Olali
Kelsey A. Carpenter
Maria Myers
Anjali Sharma
Michael T. Yin
Lena Al-Harthi
Ryan D. Ross
Publikationsdatum
20.06.2022
Verlag
Springer US
Erschienen in
Current HIV/AIDS Reports / Ausgabe 5/2022
Print ISSN: 1548-3568
Elektronische ISSN: 1548-3576
DOI
https://doi.org/10.1007/s11904-022-00613-1

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