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29.01.2016 | Review Article

Braf V600E mutation in melanoma: translational current scenario

verfasst von: J. A. Guadarrama-Orozco, A. Ortega-Gómez, E. B. Ruiz-García, H. Astudillo-de la Vega, A. Meneses-García, C. Lopez-Camarillo

Erschienen in: Clinical and Translational Oncology | Ausgabe 9/2016

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Abstract

Melanoma was one of the translational cancer examples in clinic, including target therapy related to specific biomarkers impacting in the outcome of melanoma patients. Melanomagenesis involved a wide variety of mutations during his evolution; many of these mutated proteins have a kinase activity. One of the most cited proteins in melanoma is BRAF (about 50–60 % of melanomas harbors activating BRAF mutations), for these the most common is a substitution of valine to glutamic acid at codon 600 (p.V600E). Therefore, the precise identification of this underlying somatic mutation is essential; knowing the translational implications has opened a wide view of melanoma biology and therapy.

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Titel: Braf V600E mutation in melanoma: translational current scenario
verfasst von: J. A. Guadarrama-Orozco
A. Ortega-Gómez
E. B. Ruiz-García
H. Astudillo-de la Vega
A. Meneses-García
C. Lopez-Camarillo
Publikationsdatum: 29.01.2016
Verlag: Springer International Publishing
Erschienen in: Clinical and Translational Oncology / Ausgabe 9/2016
Print ISSN: 1699-048X
Elektronische ISSN: 1699-3055
DOI: https://doi.org/10.1007/s12094-015-1469-6

Springer Medizin

Braf V600E mutation in melanoma: translational current scenario

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