Background
Methods
Subjects
Forensic group
|
Statistical analysis
| ||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Total (
n = 34)
|
Premeditated action group (
n = 15)
|
Impulsive group (
n = 19)
|
Control patient group (
n = 23)
|
Forensic (
n = 34) vs. Control (
n = 23)
a
|
Premeditated (
n = 15) vs. Control
b
|
Impulsive (
n = 19) vs. Control
c
| |||||||
Mean ± SD
|
Mean ± SD
|
Mean ± SD
|
Mean ± SD
|
t or U
|
df
|
p
|
t or U
|
df
|
p
|
t or U
|
df
|
p
| |
Age, years (range)
|
40.6 ± 9.5 (22–58)
|
44.1 ± 9.2
|
37.9 ± 9.1
|
36.8 ± 11.0 (20–53)
|
1.385
|
55
|
0.172
|
2.112
|
36
|
0.042
|
0.338
|
40
|
0.737
|
Duration of education, years
|
12.4 ± 2.7
|
11.9 ± 2.2
|
12.9 ± 3.1
|
14.4 ± 2.0
|
2.965
|
55
|
0.004
|
3.673
|
36
|
0.001
|
1.939
|
40
|
0.060
|
Substance abuse, Alcohol/Others/Both
|
2/6/2
|
1/3/0
|
1/3/2
|
0/0/0
| |||||||||
Age of onset
|
25.4 ± 7.2
|
26.3 ± 8.5
|
24.7 ± 6.1
|
22.0 ± 6.7
|
1.834
|
55
|
0.072
|
1.743
|
36
|
0.090
|
1.398
|
40
|
0.170
|
Duration of illness, years
|
15.6 ± 10.0
|
18.0 ± 10.6
|
13.8 ± 9.3
|
15.0 ± 10.4
|
0.227
|
55
|
0.822
|
0.854
|
36
|
0.399
|
0.403
|
40
|
0.689
|
Duration of untreated psychosis, months
|
26.2 ± 41.8
|
36.2 ± 55.3
|
18.3 ± 26.2
|
18.8 ± 36.3
|
465
|
0.219
|
216
|
0.202
|
249
|
0.429
| |||
Duration of medication
a
, years
|
13.2 ± 10.2
|
14.4 ± 10.5
|
12.2 ± 10.1
|
13.6 ± 10.1
|
0.164
|
55
|
0.870
|
0.233
|
36
|
0.817
|
0.457
|
40
|
0.650
|
Medication dose, mg
d
|
706.9 ± 606.4
|
682.3 ± 543.7
|
726.3 ± 665.7
|
477.3 ± 434.8
|
476.5
|
0.164
|
212.5
|
0.235
|
264
|
0.249
| |||
Medication type, Typical/Atypical/Both/Non
|
2/18/13/1
|
1/5/8/1
|
1/13/5/1
|
2/12/4/5
|
7.000
|
3
|
0.072
f
|
5.883
|
3
|
0.117
f
|
7.041
|
3
|
0.071
f
|
PANSS
e
| |||||||||||||
Positive
|
12.2 ± 4.8
|
14.3 ± 5.3
|
10.5 ± 3.8
|
9.4 ± 3.6
|
2.356
|
55
|
0.022
|
3.445
|
36
|
0.001
|
0.952
|
40
|
0.347
|
Negative
|
17.1 ± 7.0
|
19.7 ± 6.7
|
15.0 ± 6.8
|
14.7 ± 6.2
|
1.292
|
55
|
0.202
|
2.344
|
36
|
0.025
|
0.130
|
40
|
0.897
|
Disorganization
|
8.4 ± 3.2
|
9.2 ± 3.4
|
7.7 ± 2.9
|
6.8 ± 3.7
|
1.737
|
55
|
0.088
|
2.020
|
36
|
0.051
|
0.910
|
40
|
0.368
|
Depressive
|
6.7 ± 2.6
|
7.4 ± 2.9
|
6.1 ± 2.3
|
7.0 ± 3.2
|
0.420
|
55
|
0.676
|
0.395
|
36
|
0.695
|
1.024
|
40
|
0.312
|
Excitement
|
8.3 ± 3.5
|
8.4 ± 3.4
|
8.2 ± 3.8
|
6.7 ± 3.0
|
1.775
|
55
|
0.081
|
1.627
|
36
|
0.112
|
1.450
|
40
|
0.155
|
Intracranial volume, ml
|
1619.8 ± 154.2
|
1589.4 ± 173.6
|
1643.7 ± 137.1
|
1618.0 ± 136.8
|
0.045
|
55
|
0.964
|
0.565
|
36
|
0.576
|
0.606
|
40
|
0.548
|
MRI acquisition and processing
Statistical analysis
Results
Cluster | Cluster-level p value (FWE-corrected) | Number of voxels | Area | Peak coordinatea
| ||
---|---|---|---|---|---|---|
x | y | z | ||||
Forensic group (n = 34) vs. Control patient group (n = 23) | ||||||
For-1 | 0.001 | 3336 | Right ITG, Right TP, Right MTG | 44 | 0 | -42 |
46 | -6 | -50 | ||||
57 | -6 | -33 | ||||
For-2 | 0.003 | 2369 | Right PINS, Right AINS, Right VD | 38 | -6 | -16 |
40 | 3 | -9 | ||||
20 | -10 | -10 | ||||
Forensic group excluded subjects with a history of substance abuse (n = 24) vs. Control patient group (n = 23) | ||||||
For(noS)-1 | 0.043 | 1194 | Right ITG, Right TP | 45 | 0 | -40 |
48 | -6 | -50 | ||||
42 | 9 | -42 |
Cluster | Cluster-level p value (FWE-corrected) | Number of voxels | Area | Peak coordinatea
| ||
---|---|---|---|---|---|---|
x | y | z | ||||
Premeditated action group (n = 15) vs control group (n = 23) | ||||||
Prem-1 | <0.001 | 6836 | Right VD, Right AINS, Right PINS | 20 | -10 | -10 |
42 | 4 | -9 | ||||
38 | -4 | -16 | ||||
Prem-2 | 0.009 | 1789 | Left PP, Left PINS, Left AINS | -45 | -8 | -4 |
-42 | -2 | -9 | ||||
-33 | -6 | -22 | ||||
Prem-3 | 0.005 | 2109 | Left PCu, Right PCu, Left PCgG | 0 | -50 | 36 |
6 | -62 | 22 | ||||
-9 | -44 | 28 | ||||
Impulsive group (n = 19) vs control group (n = 23) | ||||||
Imp-1 | 0.02 | 1456 | Right ITG, Right TP | 45 | 0 | -40 |
46 | -6 | -50 | ||||
42 | 8 | -44 |