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International Journal of Hematology
Erschienen in: International Journal of Hematology 5/2019

23.01.2019 | Case Report

Brentuximab vedotin as frontline treatment for HIV-related extracavitary primary effusion lymphoma

verfasst von: Jose D. Sandoval-Sus, Amanda Brahim, Alina Khan, Barbara Raphael, Ali Ansari-Lari, Marco Ruiz

Erschienen in: International Journal of Hematology | Ausgabe 5/2019

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Abstract

Primary effusion lymphoma (PEL) is a rare and aggressive herpesvirus-8 (HHV-8) driven B cell non-Hodgkin’s lymphoma (NHL) that is usually associated with human immunodeficiency virus (HIV) infection, and has a poor prognosis. PEL is comprised of two clinically distinct but pathologically similar variants: classic and extracavitary PEL. Based on retrospective series, treatment options include combined antiretroviral therapy (cART) in conjunction with chemotherapy regimens used in other forms of NHLs. Treatment outcomes with this approach are usually dismal and there is no standard of care. We present a case of a patient with HIV associated CD30+ extracavitary PEL unfit for multi-agent chemotherapy, who achieved a durable complete response with single agent brentuximab-vedotin and cART.
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Metadaten
Titel
Brentuximab vedotin as frontline treatment for HIV-related extracavitary primary effusion lymphoma
verfasst von
Jose D. Sandoval-Sus
Amanda Brahim
Alina Khan
Barbara Raphael
Ali Ansari-Lari
Marco Ruiz
Publikationsdatum
23.01.2019
Verlag
Springer Japan
Erschienen in
International Journal of Hematology / Ausgabe 5/2019
Print ISSN: 0925-5710
Elektronische ISSN: 1865-3774
DOI
https://doi.org/10.1007/s12185-019-02592-3

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