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08.01.2021 | Original Contribution

Buttermilk: an important source of lipid soluble forms of choline that influences the immune system development in Sprague–Dawley rat offspring

verfasst von: Jessy Azarcoya-Barrera, Catherine J. Field, Susan Goruk, Alexander Makarowski, Jonathan M. Curtis, Yves Pouliot, René L. Jacobs, Caroline Richard

Erschienen in: European Journal of Nutrition | Ausgabe 5/2021

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Abstract

Purpose

To determine the effect of feeding buttermilk-derived choline metabolites on the immune system development in Sprague–Dawley rat pups.

Methods

Sprague–Dawley dams were randomized to one of the three diets containing 1.7 g/kg choline: 1-Control (100% free choline (FC)), 2-Buttermilk (BM, 37% phosphatidylcholine (PC), 34% sphingomyelin (SM), 17% glycerophosphocholine (GPC), 7% FC, 5% phosphocholine), and 3-Placebo (PB, 50% PC, 25% FC, 25% GPC) until the end of the lactation period. At weaning, pups continued on the same diet as their mom. Cell phenotypes and cytokine production by mitogen-stimulated splenocytes isolated from 3- and 10-week-old pups were measured.

Results

At 3 weeks, BM-pups had a higher proportion of cytotoxic T cells (CTL; CD3 + CD8 +) while both BM- and PB-pups had an increased proportion of cells expressing CD28 + , CD86 + and CD27 + (all p > 0.05). Following ConA stimulation, splenocytes from BM- and PB-pups produced more TNF-α and IFN-γ and after LPS stimulation produced more IL-10 and TNF-α (all p > 0.05). Starting at week 6 of age, BM-pups had a higher body weight. At 10 weeks, both the BM- and PB-pups had a higher proportion of CTL expressing CD27 + . After ConA stimulation, splenocytes from BM- and PB-pups produced more IL-2, IFN-γ and IL-6 and more IL-10 after LPS stimulation (all p > 0.05).

Conclusion

The proportion of lipid soluble forms of choline in the diet during lactation and weaning periods influence the immune system development in rat offspring.

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Titel: Buttermilk: an important source of lipid soluble forms of choline that influences the immune system development in Sprague–Dawley rat offspring
verfasst von: Jessy Azarcoya-Barrera
Catherine J. Field
Susan Goruk
Alexander Makarowski
Jonathan M. Curtis
Yves Pouliot
René L. Jacobs
Caroline Richard
Publikationsdatum: 08.01.2021
Verlag: Springer Berlin Heidelberg
Erschienen in: European Journal of Nutrition / Ausgabe 5/2021
Print ISSN: 1436-6207
Elektronische ISSN: 1436-6215
DOI: https://doi.org/10.1007/s00394-020-02462-3

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