Background
Methods
Search strategy and information sources
Study selection and eligibility criteria
Exposure and outcome measures
Assessment of heterogeneity
Risk of bias and quality assessment
Statistical analysis
Results
Search results
Study characteristics
Study ID and Location | Study Design | Number of Participants, n (singletons) | Maternal Age, mean ± SD number or % | Exposure | NOS Score |
---|---|---|---|---|---|
Anzola et al. (2019) [26] France | Retrospective hospital- based/ Matched | Fresh ET = 5883 Frozen ET= 366 SC = 6981 | Fresh ET 32.8 ± 4.4 Frozen ET 33.1 ± 4.3 SC not available | IVF and IVF + ICSI, Fresh ET or Frozen ET | 8 |
Apantaku et al. (2008) [27] England | Retrospective hospital- based/ Matched | ART = 88 SC = 88 | ART 33.5 + 4.0 SC-33.2 + 4.1 | IFV/ICSI | 8 |
Beyer et al. (2016) [40] Germany | Retrospective hospital- based | ART = 467 SC = 6417 | ART 33.7 + 4.0 SC 28 | ART (Fresh ET, Slow-rate Freezing, Vitrification) | 7 |
Buckett et al. (2007) [28] Canada | Retrospective hospital- based/ Matched | IVF = 133 ICSI = 104 SC = 338 | IVF 35 ICSI- 34 SC 34 | Fresh ET after IVF Fresh ET after ICSI | 9 |
Carbillon et al. (2017) [41] France | Retrospective hospital- based | IVF/ICSI = 119 SC = 7993 | Mild ovarian stimulation with ART- 30.2 + 5.9 Multi-follicular stimulation and ART- 29.9 + 6.0 SC - 29.7 + 5.8 | IFV/ICSI (Excluded oocyte donation, previous diabetes) | 7 |
Dayan et al. (2018) [42] Canada | Retrospective population-based | IVF = 1596 SC = 112,813 | IVF 35.7 ± 4.6 SC 30.3 ± 5.2 | IVF including (ICSI both fresh and frozen embryo transfer) | 9 |
D’Souza et al. (1997) [29] England | Prospective hospital-based/Matched | IVF = 150 SC = 150 | Not available | Fresh ET after IVF | 9 |
Ensing et al. (2015) [30] Netherlands | Retrospective population-based/ Matched/ adjusted | IVF = 16,177 SC = 1,905,011 | IFV 32.7 + 4.6 SC 32.7 + 4.5 | IVF as a subgroup | 9 |
Ernstad et al. (2016) [43] Sweden | Retrospective population-based | Fresh ET = 22,771 Frozen ET = 7795 SC = 1,196,394 | > 35 years All blastocyst (47.1%) All cleavage (45.7%) SC (20.4%) | Fresh ET after IVF Frozen ET after IVF (excluded oocyte donation) | 7 |
Farhi et al. (2013) [44] Israel | Prospective hospital-based | IVF = 202 ICSI = 307 SC = 587 | ART - 33.1 ± 4.9 SC - 30.1 ± 4.9 | ART (IVF and ICSI) | 6 |
Fedder et al. (2013) [18] Denmark | Retrospective population-based/ Matched/ adjusted | ICSI = 6156 IVF = 11,060 SC = 33,852 | ICSI (Group A = 32.78 + 4.27, Group B = 33.16 + 4.05) IVF (Group C): 34.01 + 4.04 SC (Group D): 30.23 + 4.86 | IVF and ICSI | 9 |
Gambadauro et al. (2017) [45] Sweden | Prospective population-based | IVF = 167 SC = 3116 | > 35 years IVF 46.1% SC 22.6% | IVF with or without ICSI | 7 |
Gillet et al. (2011) [31] Belgium | Retrospective population-based/Matched | IVF/ICSI = 1866 SC = 15,228 | IVF/ICSI − 37.8 ± 2.4 SC 37.3 ± 2.0 | IFV/ICSI | 9 |
Harlev et al. (2018) [46] Israel | Retrospective hospital- based | IVF = 229 SC = 7929 | IVF 41 + 1.35 SC 41 + 1.20 | IVF and Ovulation induction | 9 |
Katalinic et al. (2004) [19] Germany | Prospective hospital-based | ICSI = 2055 SC = 7861 | ICSI 32.9 + 3.9 SC 27.0 + 4.7 | Fresh embryo transfer (ET) after ICSI | 7 |
Koudstaal et al. (2000) [20] Netherlands | Retrospective hospital- based/ Matched | IVF = 307 SC = 307 | IVF 32.8 (+ 4.3) SC 32.7 + (4.4) | Fresh ET after IVF (excluded frozen and embryo reduction) | 9 |
Liu et al. (2015) [53] China | Retrospective hospital- based | IVF = 380 SC = 405 | IVF/ICSI 31.59 ± 3.48 years SC 31.31 ± 3.45 years | IVF/ICSI | 4 |
Malchau et al. (2014) [47] Denmark | Retrospective population-based | IVF = 4135 ICSI = 3635 SC = 229,749 | IVF 34.2 (+ 4.4) ICSI 33.4 (+ 4.3) SC 30.7 (+ 4.9) | IUI IVF and ICSI | 9 |
Ochsenkuhn et al. (2003) [32] Germany | Retrospective hospital- based/ Matched/ adjusted | IVF = 163 SC = 322 | IVF 32.6 SC 32.2 | IVF GIFT | 9 |
Olivennes et al. (1993) [21] France | Retrospective hospital- based | IVF = 162 SC = 5096 | IVF 33.6 ± 3.9 SC 29.9 ± 4.7 | IVF | 7 |
Olson et al. (2005) [33] United States | Retrospective hospital- based/ Matched | IVF/ICSI = 645 SC = 4590 | IVF 33.9 + 4.6 SC 33.3 + 4.3 | IVF/ICSI | 8 |
Perri et al. (2001) [34] Israel | Retrospective hospital- based/ Matched | ART = 95 SC = 190 | ART 32.15 + 4.5 SC 32.13 + 4.5 | IFV/ICSI Transferring both IVF- and ICSI-derived embryos | 9 |
Pinborg et al. (2010) [35] Denmark | Retrospective population-based/ Matched/ adjusted | Frozen = 957 Fresh =10,329 Non-ART = 4800 | Frozen 34.0 (3.8) Fresh 33.7 (4.0) Non-ART 30.1 (4.8) | Frozen ET after IVF/ICSI Fresh ET after IVF/ICSI | 8 |
Poikkeus et al. (2007) [36] Finland | Retrospective hospital- based/ Matched/ adjusted | IVF/ICSI = 499 (SET = 269; DET = 230) SC = 15,037 | Single ET 32.6 + 3.9 Double ET 34.2 + 3.8 SC 30.3 + 5.3 | IFV/ICSI (Single ET or Double ET) | 8 |
Rahu et al. (2019) [48] Estonia | Retrospective population-based | IVF/ICSI = 1778 SC = 33,555 | IVF/ICSI 32.5 ± 3.8 SC 28.6 ± 3.3 | IVF/ICSI, autologous | 9 |
Romundstad et al. (2008) [49] Norway | Retrospective population-based | ART = 8229 SC = 1,200,922 | All ranges, and ≥35 years ART 35% SC 12% | IFV/ICSI | 9 |
Sazonova et al. (2012) [50] Sweden | Retrospective population-based | Frozen = 2348 Fresh = 8944 SC = 571,914 | n 30–39 ART = 8754 SC = 297,818 n ≥ 40 ART = 836 SC = 18,096 | Frozen ET after IVF/ICSI Fresh ET after IVF/ICSI (excluded oocyte donation) | 9 |
Shevell et al. (2005) [22] United States | Prospective hospital-based | ART = 554 SC = 34,286 | IVF 34.5 (+ 5.2) SC 29.9 (+ 5.7) | IVF ICSI GIFT/ZIFT | 8 |
Stojnic et al. (2013) [37] Serbia | Retrospective hospital- based/ Matched / adjusted | IVF = 351 ICSI = 283 SC = 634 | IVF/ICSI 36 ± 4.2 SC 35 ± 4.1 | IVF/ICSI (excluded oocyte donation, frozen and vanishing twins) | 9 |
Sun et al. (2014) [38] Canada | Retrospective hospital- based/ Matched/adjusted | ART = 1327 SC = 5222 | All ranges, and ≥ 35 years: ART 51% SC 50% | IFV/ICSI | 9 |
Suzuki et al. (2007) [51] Japan | Retrospective hospital- based | IVF-ET = 89 SC = 849 | All ≥35 years | IVF/ICSI | 8 |
Tomic et al. (2011) [39] Croatia | Retrospective hospital- based/ Matched | IVF = 283 SC = 283 | IVF = 37.8 ± 3.9 SC = 37.4 ± 3.8 | IVF in advanced age (excluded oocyte donation, cryopreservation, vanishing twins) | 9 |
Toshimitsu et al. (2014) [52] Tokyo | Retrospective hospital- based | IVF/ICSI = 116 SC = 662 | IVF/ICSI41.5 ± 1.5 SC 41.2 ± 1.4 | IVF/ICSI, autologous | 7 |
Wennerholm et al. (2013) [23] Denmark, Norway and Sweden | Retrospective population-based/Matched/ adjusted | Frozen ET = 6647 Fresh ET = 42,242 SC = 288,542 | Frozen: 33.7 + 3.9 Fresh: 33.3 + 4.0 SC:28.5 + 5.0 | Frozen ET after IVF/ICSI | 9 |