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Erschienen in:
01.01.2014 | Short Communication
Calcium carbonate does not affect imatinib pharmacokinetics in healthy volunteers
Erschienen in: Cancer Chemotherapy and Pharmacology | Ausgabe 1/2014
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Purpose
Imatinib mesylate (Gleevec®/Glivec®) has revolutionized the treatment of chronic myeloid leukemias and gastrointestinal stromal tumors, and there is evidence for an exposure response relationship. Calcium carbonate is increasingly used as a calcium supplement and in the setting of gastric upset associated with imatinib therapy. Calcium carbonate could conceivably elevate gastric pH and complex imatinib, thereby influencing imatinib absorption and exposure. We aimed to evaluate whether use of calcium carbonate has a significant effect on imatinib pharmacokinetics.
Methods
Eleven healthy subjects were enrolled in a 2-period, open-label, single-institution, randomized crossover, fixed-schedule study. In one period, each subject received 400 mg of imatinib p.o. In the other period, 4,000 mg calcium carbonate (Tums Ultra®) was administered p.o. 15 min before 400 mg of imatinib. Plasma concentrations of imatinib and its active N-desmethyl metabolite CGP74588 were assayed by LC–MS; data were analyzed non-compartmentally and compared after log transformation.
Results
Calcium carbonate administration did not significantly affect the imatinib area under the plasma concentration versus time curve (AUC) (41.2 μg/mL h alone vs. 40.8 μg/mL h with calcium carbonate, P = 0.99), maximum plasma concentration (C
max) (2.35 μg/mL alone vs. 2.39 μg/mL with calcium carbonate, P = 0.89).
Conclusions
Our results indicate that the use of calcium carbonate does not significantly affect imatinib pharmacokinetics.