Ausgabe 1/2014
Inhalt (25 Artikel)
Mechanisms of action of tasquinimod on the tumour microenvironment
E. Raymond, A. Dalgleish, J.-E. Damber, M. Smith, R. Pili
Open-label, randomized, single-dose, crossover study to evaluate the pharmacokinetics and safety differences between two docetaxel products, CKD-810 and Taxotere injection, in patients with advanced solid cancer
Eun Kyung Cho, Ji-Young Park, Kyung Hee Lee, Hong Suk Song, Young Joo Min, Yeul Hong Kim, Jin-Hyoung Kang
A phase II study of pemetrexed in patients with previously heavily treated non-squamous non-small cell lung cancer (HANSHIN Oncology Group 001)
Yoshihiro Hattori, Miyako Satouchi, Nobuyuki Katakami, Shiro Fujita, Reiko Kaji, Akito Hata, Yoshiko Urata, Temiko Shimada, Junji Uchida, Keisuke Tomii, Satoshi Morita, Shunichi Negoro
Toll-like receptor signaling regulates cisplatin-induced mechanical allodynia in mice
Hue Jung Park, Jennifer A. Stokes, Maripat Corr, Tony L. Yaksh
Evaluation of the QTc prolongation potential of a monoclonal antibody, siltuximab, in patients with monoclonal gammopathy of undetermined significance, smoldering multiple myeloma, or low-volume multiple myeloma
Sheeba K. Thomas, Alexander Suvorov, Lucien Noens, Oleg Rukavitsin, Joseph Fay, Ka Lung Wu, Todd M. Zimmerman, Helgi van de Velde, Rajesh Bandekar, Thomas A. Puchalski, Ming Qi, Clarissa Uhlar, Olga S. Samoylova
Longitudinal assessment of TUBB3 expression in non-small cell lung cancer patients
Jan Nyrop Jakobsen, Eric Santoni-Rugiu, Jens Benn Sørensen
Peptide-based inhibition of the HOXA9/PBX interaction retards the growth of human meningioma
Hitoshi Ando, Atsushi Natsume, Takeshi Senga, Reiko Watanabe, Ichiro Ito, Masasuke Ohno, Kenichiro Iwami, Fumiharu Ohka, Kazuya Motomura, Sayano Kinjo, Maki Ito, Kiyoshi Saito, Richard Morgan, Toshishiko Wakabayashi
Pegylated liposomal doxorubicin and cyclophosphamide in early recurrent ovarian carcinoma: phase I dose-finding study
Anne Floquet, Adélaïde Doussau, Véronique Brouste, Laurent Cany, Jean-Philippe Dutin, Simone Mathoulin-Pélissier
Bortezomib-induced apoptosis in cultured pancreatic cancer cells is associated with ceramide production
Lei Gong, Bo Yang, Ming Xu, Bo Cheng, Xuejun Tang, Ping Zheng, Yan Jing, Gao-jue Wu
Serum creatinine and creatinine clearance for predicting plasma methotrexate concentrations after high-dose methotrexate chemotherapy for the treatment for childhood lymphoblastic malignancies
Wei-qun Xu, Ling-yan Zhang, Xue-ying Chen, Bin-hua Pan, Jun-qing Mao, Hua Song, Jing-yuang Li, Yong-min Tang
Midazolam as a phenotyping probe to predict sunitinib exposure in patients with cancer
D. de Wit, H. Gelderblom, A. Sparreboom, J. den Hartigh, M. den Hollander, J. M. C. König-Quartel, T. Hessing, H. J. Guchelaar, N. P. van Erp
Phase II clinical study of alternate-day oral therapy with S-1 as first-line chemotherapy for locally advanced and metastatic pancreatic cancer
Hiroki Yamaue, Sohei Satoi, Takamasa Kanbe, Motoki Miyazawa, Masaji Tani, Manabu Kawai, Seiko Hirono, Kenichi Okada, Hiroaki Yanagimoto, A-Hon Kwon, Tomoyuki Mukouyama, Hiroaki Tsunoda, Kazuo Chijiiwa, Jiro Ohuchida, Jun Kato, Kazuki Ueda, Taketo Yamaguchi, Shinichi Egawa, Kazuhiko Hayashi, Tetsuhiko Shirasaka
A phase I, randomized, open-label study of the multiple-dose pharmacokinetics of vemurafenib in patients with BRAF V600E mutation-positive metastatic melanoma
J. F. Grippo, W. Zhang, D. Heinzmann, K. H. Yang, J. Wong, A. K. Joe, P. Munster, N. Sarapa, A. Daud
Safety and pharmacology of gemcitabine and capecitabine in patients with advanced pancreatico-biliary cancer and hepatic dysfunction
M. Joerger, A. D. R. Huitema, D. Koeberle, H. Rosing, J. H. Beijnen, F. Hitz, T. Cerny, J. H. M. Schellens, S. Gillessen
Randomized double-blinded, placebo-controlled phase II trial of simvastatin and gemcitabine in advanced pancreatic cancer patients
Jung Yong Hong, Eun Mi Nam, Jeeyun Lee, Joon Oh Park, Sang-Cheol Lee, Seo-Young Song, Seong Ho Choi, Jin Seok Heo, Se Hoon Park, Ho Yeong Lim, Won Ki Kang, Young Suk Park
Changes in epidermal growth factor receptor expression during chemotherapy in non-small cell lung cancer
Jan Nyrop Jakobsen, Eric Santoni-Rugiu, Jens Benn Sørensen
Enhanced efficacy of postoperative adjuvant chemotherapy in advanced gastric cancer: results from a phase 3 randomized trial (AMC0101)
Yoon-Koo Kang, Jeong Hwan Yook, Heung-Moon Chang, Min-Hee Ryu, Changhoon Yoo, Dae Young Zang, Jae-Lyun Lee, Tae Won Kim, Dae Hyun Yang, Se Jin Jang, Young Soo Park, Young Jack Lee, Hwoon-Yong Jung, Jin-Ho Kim, Byung Sik Kim
Circulating proteins as potential biomarkers of sunitinib and interferon-α efficacy in treatment-naïve patients with metastatic renal cell carcinoma
Charles S. Harmon, Samuel E. DePrimo, Robert A. Figlin, Gary R. Hudes, Thomas E. Hutson, M. Dror Michaelson, Sylvie Négrier, Sindy T. Kim, Xin Huang, J. Andrew Williams, Tim Eisen, Robert J. Motzer
A randomized phase II study of weekly docetaxel/cisplatin versus weekly docetaxel/oxaliplatin as first-line therapy for patients with advanced gastric cancer
Young Saing Kim, Sun Jin Sym, Se Hoon Park, Inkeun Park, Junshik Hong, Hee Kyung Ahn, Jinny Park, Eun Kyung Cho, Woon Ki Lee, Min Chung, Jae Hoon Lee, Dong Bok Shin
E5501: phase II study of topotecan sequenced with etoposide/cisplatin, and irinotecan/cisplatin sequenced with etoposide for extensive-stage small-cell lung cancer
Taofeek K. Owonikoko, Joseph Aisner, Xin Victoria Wang, Suzanne E. Dahlberg, Eric H. Rubin, Suresh S. Ramalingam, Murugesan Gounder, Paul Gregory Rausch, Rita S. Axelrod, Joan H. Schiller
A phase 1b clinical trial of the multi-targeted tyrosine kinase inhibitor lenvatinib (E7080) in combination with everolimus for treatment of metastatic renal cell carcinoma (RCC)
Ana M. Molina, Thomas E. Hutson, James Larkin, Anne M. Gold, Karen Wood, Dave Carter, Robert Motzer, M. Dror Michaelson
Efficacy of concurrent chemoradiotherapy with 5-fluorouracil or gemcitabine in locally advanced biliary tract cancer
Seung Woo Yi, Dae Ryong Kang, Kyung Sik Kim, Mi Suk Park, Jinsil Seong, Jeong Youp Park, Seung Min Bang, Si Young Song, Jae Bock Chung, Seung Woo Park
The effect of chemotherapy with cisplatin and pemetrexed for choroidal metastasis of non-squamous cell carcinoma
Chih-Jen Yang, Ying-Ming Tsai, Ming-Ju Tsai, Hsu-Liang Chang, Ming-Shyan Huang
Calcium carbonate does not affect imatinib pharmacokinetics in healthy volunteers
Hussein Tawbi, Susan M. Christner, Yan Lin, Matthew Johnson, Emily T. Mowrey, Craig Cherrin, Edward Chu, James J. Lee, Shannon Puhalla, Ronald Stoller, Leonard R. Appleman, Brian M. Miller, Jan H. Beumer
Results of a phase I, open-label, randomized, crossover study evaluating the effects of linifanib on QTc intervals in patients with solid tumors
Yi-Lin Chiu, Patricia LoRusso, Balakrishna Hosmane, Justin L. Ricker, Walid Awni, Dawn M. Carlson