Ausgabe 4/2010
Inhalt (21 Artikel)
Identification of type-specific anticancer histone deacetylase inhibitors: road to success
Nighat Noureen, Hamid Rashid, Saima Kalsoom
Antitumor activity and pharmacokinetics of oral gimatecan on pediatric cancer xenografts
Massimo Zucchetti, Daniela Meco, Angela Maria Di Francesco, Tiziana Servidei, Valentina Patriarca, Gabriella Cusano, Maurizio D’Incalci, Daniele Forestieri, Claudio Pisano, Riccardo Riccardi
Concurrent chemoradiation followed by adjuvant chemotherapy in patients with locoregionally advanced nasopharyngeal carcinoma in Korea
Kyong Hwa Park, Jeong Sun Kim, Yong Park, Hee Yeon Seo, Young Je Park, In Keun Choi, Sang Chul Oh, Jae Hong Seo, Chul Yong Kim, Kwang Yoon Jung, Sang Won Shin, Yeul Hong Kim, Jun Suk Kim, Nam Joon Lee
The impact of high-dose methotrexate on intracellular 6-mercaptopurine disposition during interval therapy of childhood acute lymphoblastic leukemia
T. Adam de Beaumais, T. Dervieux, M. Fakhoury, Y. Medard, S. Azougagh, D. Zhang, K. Yakouben, E. Jacqz-Aigrain
Clinical impact of microsatellite instability in colon cancer following adjuvant FOLFOX therapy
Seung Tae Kim, Jeeyun Lee, Se Hoon Park, Joon Oh Park, Ho Yeong Lim, Won Ki Kang, Jin Yong Kim, Young Ho Kim, Dong Kyung Chang, Poong-Lyul Rhee, Dae Shick Kim, Haeran Yun, Yong Beom Cho, Hee Cheol Kim, Seong Hyeon Yun, Woo Yong Lee, Ho-Kyung Chun, Young Suk Park
Sunitinib in combination with docetaxel in patients with advanced solid tumors: a phase I dose-escalation study
Francisco Robert, Alan Sandler, Joan H. Schiller, Glenn Liu, Karen Harper, Lev Verkh, Xin Huang, Jennifer Ilagan, Lesley Tye, Richard Chao, Anne M. Traynor
Down-regulation of heat shock protein 70 improves arsenic trioxide and 17-DMAG effects on constitutive signal transducer and activator of transcription 3 activity
Sampa Ghoshal, Indranil Rao, Justin C. Earp, William J. Jusko, Meir Wetzler
Impact of functional ABCG2 polymorphisms on the adverse effects of gefitinib in Japanese patients with non–small-cell lung cancer
Keiichi Akasaka, Takayuki Kaburagi, Shin’ichi Yasuda, Kyoko Ohmori, Kaori Abe, Hironori Sagara, Yoshihiko Ueda, Koshu Nagao, Johji Imura, Yasuo Imai
Pharmacokinetics of sunitinib malate in subjects with hepatic impairment
Carlo L. Bello, May Garrett, Laurie Sherman, John Smeraglia, Bob Ryan, Melvin Toh
Corchorusin-D, a saikosaponin-like compound isolated from Corchorus acutangulus Lam., targets mitochondrial apoptotic pathways in leukemic cell lines (HL-60 and U937)
Sumana Mallick, Papiya Ghosh, Suman K. Samanta, Sumita Kinra, Bikas C. Pal, Aparna Gomes, Joseph R. Vedasiromoni
Phase II study of S-1, docetaxel and cisplatin combination chemotherapy in patients with unresectable metastatic gastric cancer
Yasushi Sato, Tetsuji Takayama, Tamotsu Sagawa, Yasuo Takahashi, Hiroyuki Ohnuma, Syunichi Okubo, Naoaki Shintani, Shingo Tanaka, Masaya Kida, Yasuhiro Sato, Hidetoshi Ohta, Koji Miyanishi, Tsutomu Sato, Rishu Takimoto, Masayoshi Kobune, Koji Yamaguchi, Koichi Hirata, Yoshiro Niitsu, Junji Kato
Randomized controlled phase II comparison study of concurrent chemoradiotherapy with docetaxel, cisplatin, and 5-fluorouracil versus CCRT with cisplatin, 5-fluorouracil, methotrexate and leucovorin in patients with locally advanced squamous cell carcinoma of the head and neck
Mamoru Tsukuda, Junichi Ishitoya, Hideki Matsuda, Choichi Horiuchi, Takahide Taguchi, Masahiro Takahashi, Goshi Nishimura, Mariko Kawakami, Makiko Watanabe, Tatsuo Niho, Toshiro Kawano, Yoichi Ikeda, Yasunori Sakuma, Osamu Shiono, Masanori Komatsu
Pharmacokinetics of orally administered ABT-751 in children with neuroblastoma and other solid tumors
Elizabeth Fox, John M. Maris, Susan L. Cohn, Wendy Goodspeed, Anne Goodwin, Marie Kromplewski, Diane Medina, Hao Xiong, Andrew Krivoshik, Brigitte Widemann, Peter C. Adamson, Frank M. Balis
Biodistribution of humanized anti-VEGF monoclonal antibody/bevacizumab on peritoneal metastatic models with subcutaneous xenograft of gastric cancer in mice
Yasumichi Yagi, Sachio Fushida, Shinichi Harada, Tomoya Tsukada, Jun Kinoshita, Katsunobu Oyama, Hideto Fujita, Itasu Ninomiya, Takashi Fujimura, Masato Kayahara, Seigo Kinuya, Masakazu Yashiro, Kousei Hirakawa, Tetsuo Ohta
Inhibition of experimental colorectal cancer and reduction in renal and gastrointestinal toxicities by copper–indomethacin in rats
Antonio M. Bonin, Jaime A. Yáñez, Chie Fukuda, Xiao Wei Teng, Carolyn T. Dillon, Trevor W. Hambley, Peter A. Lay, Neal M. Davies
PXR-mediated induction of P-glycoprotein by anticancer drugs in a human colon adenocarcinoma-derived cell line
Stefan Harmsen, I. Meijerman, C. L. Febus, R. F. Maas-Bakker, J. H. Beijnen, J. H. M. Schellens
Intravenous paclitaxel against metastasis of human gastric tumors of diffuse type
Tsung-Fan Tuan, Meng-Li Tsai, Kai-Chia Yeh, Hsin-Chieh Huang, Cheng-Ta Chung, Chen-Lung Huang, Chia-Hung Han, Ching-Ping Chen, Min-Hsien Wang, Chien-Chang Shen, Yiu-Kay Lai, Wen-Sen Lee, Ling-Ling Hwang, Chiung-Tong Chen
Semi-mechanistic population pharmacokinetic/pharmacodynamic model for neutropenia following therapy with the Plk-1 inhibitor BI 2536 and its application in clinical development
Elena Soto, Alexander Staab, Christiane Tillmann, Dirk Trommeshauser, Holger Fritsch, Gerd Munzert, Iñaki F. Trocóniz
Outcomes of multiple salvage chemotherapy for advanced gastric cancer: implications for clinical practice and trial design
Yong Wha Moon, Sun Young Rha, Hei-Cheul Jeung, Chan Kim, Min Hee Hong, Hyun Chang, Jae Kyung Roh, Sung Hoon Noh, Byung Soo Kim, Hyun Cheol Chung
Doxorubicin-induced suppression of poly(ADP-ribose) polymerase-1 (PARP-1) activity and expression and its implication for PARP inhibitors in clinical trials
Tomasz Zaremba, Huw Thomas, Michael Cole, Elizabeth R. Plummer, Nicola J. Curtin
Pharmacokinetic analysis of carboplatin in patients with cancer who are undergoing hemodialysis
Tomoyo Oguri, Tomoya Shimokata, Megumi Inada, Isao Ito, Yuichi Ando, Yasutsuna Sasaki, Yoshinori Hasegawa