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Current Hematologic Malignancy Reports

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17.08.2018 | Acute Lymphocytic Leukemias (K Ballen and M Keng, Section Editors)

CAR-T Cell Therapy for Acute Lymphoblastic Leukemia: Transforming the Treatment of Relapsed and Refractory Disease

verfasst von: Katherine C. Pehlivan, Brynn B. Duncan, Daniel W. Lee

Erschienen in: Current Hematologic Malignancy Reports | Ausgabe 5/2018

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Abstract

Purpose of Review

Genetically engineered T cells expressing a chimeric antigen receptor (CAR-T) targeting specific antigens present on acute lymphoblastic leukemia (ALL) blasts have generated promising results in children and adults with relapsed and refractory disease. We review the current evidence for CAR-T cell therapy in ALL, associated toxicities, and efforts to improve durable response to therapy.

Recent Findings

CD19-directed CAR-T cells have recently been approved by the FDA for use in children and young adults with ALL and in adults with diffuse large B cell lymphoma (DLBCL) in the relapsed/refractory setting. CD22-directed CAR-T cells have shown efficacy against leukemia as well in a recent clinical trial, representing the first alternative CAR target to approach comparable efficacy to CD19 CAR-T cells. Standardization of toxicity grading and management, strategies to combat significant relapse rates after CAR-T therapy, and applicability of CAR-T cells to treat central nervous system (CNS) disease remain challenges in the field and represent priorities for continued research.

Summary

CAR-T cells are a feasible, effective, and rapidly evolving therapy for patients with relapsed and refractory B cell malignancies.

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Titel: CAR-T Cell Therapy for Acute Lymphoblastic Leukemia: Transforming the Treatment of Relapsed and Refractory Disease
verfasst von: Katherine C. Pehlivan
Brynn B. Duncan
Daniel W. Lee
Publikationsdatum: 17.08.2018
Verlag: Springer US
Erschienen in: Current Hematologic Malignancy Reports / Ausgabe 5/2018
Print ISSN: 1558-8211
Elektronische ISSN: 1558-822X
DOI: https://doi.org/10.1007/s11899-018-0470-x

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