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Journal of Echocardiography
Erschienen in: Journal of Echocardiography 3/2016

30.06.2016 | Original Investigation

Carotid atherosclerosis is associated with left ventricular diastolic function

verfasst von: Masahiko Harada, Satoshi Tabako

Erschienen in: Journal of Echocardiography | Ausgabe 3/2016

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Abstract

Background

It has been reported that carotid intima-media thickness (IMT) correlates with the risk of stroke or cardiovascular disease. The purpose of this study was to analyze the relationships between echocardiographic findings and carotid atherosclerosis.

Methods

A total of 234 patients (62 ± 15 years) were referred for echocardiography to evaluate the left ventricular (LV) function. The LV ejection fraction, the ratio of the peak velocity of early rapid filling and the peak velocity of atrial filling (E/A), and the peak early diastolic mitral annular velocity (e′) were obtained by echocardiography. The maximum IMT (Max-IMT) and plaque score (PS) were measured by carotid ultrasonography within 1 month of the echocardiographic examination.

Results

The mean values of Max-IMT and carotid PS were 2.41 ± 1.23 mm and 8.5 ± 6.3, respectively. The decreased mean E/A (0.94 ± 0.39) and mitral e′ (5.5 ± 1.9 cm/s) indicated LV diastolic dysfunction. A good correlation was observed between Max-IMT and PS (r = 0.83, p < 0.0001). It was shown that 2.8 mm of Max-IMT was equivalent to 10.1 of carotid PS, which indicated severe carotid atherosclerosis. In multiple logistic stepwise regression analysis, among the echocardiographic parameters, only e′ was independently associated with severe carotid atherosclerosis (Max-IMT ≥ 2.8 mm or PS ≥ 10.1).

Conclusions

The present study demonstrated that decreased early diastolic mitral annular velocity relates to the parameter reflecting carotid atherosclerosis. Therefore, the presence of severe carotid atherosclerosis may affect LV diastolic dysfunction.
Literatur
1.
Prati P, Tosetto A, Vanuzzo D, et al. Carotid intima media thickness and plaques can predict the occurrence of ischemic cerebrovascular events. Stroke. 2008;39:2470–6.CrossRefPubMed
2.
Nambi V, Chambless L, Folson AR, et al. Carotid intima-media thickness and presence or absence of plaque improves prediction of coronary heart disease risk: the ARIC (Atherosclerosis Risk in Communities) study. J Am Coll Cardiol. 2010;55:1600–7.CrossRefPubMedPubMedCentral
3.
Den Ruijter HM, Peters SAE, Anderson T, et al. Common carotid intima-media thickness measurements in cardiovascular risk prediction a meta-analysis. JAMA. 2012;308:796–803.CrossRef
4.
5.
Naqvi T, Lee MS. Carotid intima-media thickness and plaque in cardiovascular risk assessment. J Am Coll Cardiol Img. 2014;7:1025–38.CrossRef
6.
Laurent S, Boutouyrie P, Asmer R, et al. Aortic stiffness is an independent predictor of all-cause and cardiovascular mortality in hypertensive patients. Hypertension. 2001;37:1236–41.CrossRefPubMed
7.
Shoji T, Emoto M, Shinohara K, et al. Diabetes mellitus, aortic stiffness, and cardiovascular mortality in end-stage renal disease. J Am Soc Nephrol. 2001;12:2117–24.PubMed
8.
Wang KL, Cheng HM, Sung SH, et al. Wave reflection and arterial stiffness in the prediction of 15-year all-cause and cardiovascular mortalities. A community-based study. Hypertension. 2010;55:799–805.CrossRefPubMedPubMedCentral
9.
Shoji T, Maekawa k, Emoto M, et al. Arterial stiffness predicts cardiovascular death independent of arterial thickness in a cohort of hemodialysis patients. Atherosclerosis. 2010;2010:145–9.CrossRef
10.
Vinereanu D, Nicolaides E, Boden L, et al. Conduit arterial stiffness is associated with impaired left ventricular subendocardial function. Heart. 2003;89:449–51.CrossRefPubMedPubMedCentral
11.
Yambe M, Tomiyama H, Hirayama Y, et al. Arterial stiffening as a possible risk factor for both atherosclerosis and diastolic heart failure. Hypertens Res. 2004;27:625–31.CrossRefPubMed
12.
Eren M, Gorgulu S, Uslu N, et al. Relation between aortic stiffness and left ventricular diastolic function in patients with hypertension, diabetes, or both. Heart. 2004;90:37–43.CrossRefPubMedPubMedCentral
13.
Mottram PM, Haluska BA, Leano R, et al. Relation of arterial stiffness to diastolic dysfunction in hypertensive heart disease. Heart. 2005;91:1551–6.CrossRefPubMedPubMedCentral
14.
Crouse JR, Harpold GH, Kahl FR, et al. Evaluation of a scoring system for extracranial carotid atherosclerosis extent with B-mode ultrasound. Stroke. 1986;17:270–5.CrossRefPubMed
15.
Handa N, Matsumoto M, Maeda H, et al. Ultrasonic evaluation of early carotid atherosclerosis. Stroke. 1990;21:1567–72.CrossRefPubMed
16.
Lester SJ, Ryan EW, Schiller NB, et al. Best method in clinical practice and in research studies to determine left atrial size. Am J Cardiol. 1999;84:829–32.CrossRefPubMed
17.
Devereux RB, Reicheck N. Echocardiographic determination of left ventricular mass in man: anatomic validation of the method. Circulation. 1977;55:613–8.CrossRefPubMed
18.
Poli A, Tremoli E, Colombo A, et al. Ultrasonographic measurement of the common carotid artery wall thickness in hypercholesterolemic patients: a new model for the quantitation and follow-up of preclinical atherosclerosis in living human subjects. Atherosclerosis. 1988;70:253–6.CrossRefPubMed
19.
O’Leary DH, Polak JF, Kronmal RA, et al. Distribution and correlates of sonographically detected carotid artery disease in the Cardiovascular Health Study. Stroke. 1992;23:1752–60.CrossRefPubMed
20.
Bots ML, Breslau PJ, Briet E, et al. Cardiovascular determinants of carotid artery disease: the Rotterdam Elderly Study. Hypertension. 1992;19:717–20.CrossRefPubMed
21.
Burke GL, Evans GW, Riley WA, et al. Arterial wall thickness is associated with prevalent cardiovascular disease in middle-aged adults: the atherosclerosis risk in communities (ARIC) Study. Stroke. 1995;26:386–91.CrossRefPubMed
22.
Mannami T, Konishi M, Baba S, et al. Prevalence of asymptomatic carotid atherosclerotic lesions detected by high-resolution ultrasonography and its relation to cardiovascular risk factors in the general population of a Japanese city: the Suita study. Stroke. 1997;28:518–25.CrossRefPubMed
23.
Allan PL, Mowbray PI, Lee AJ, et al. Relationship between carotid intima-media thickness and symptomatic and asymptomatic peripheral arterial disease: the Edinburgh Artery Study. Stroke. 1997;28:348–53.CrossRefPubMed
24.
O’Leary DH, Polak JF, Kronmal RA, et al. Carotid artery intima and media thickness as a risk factor for myocardial infarction and stroke in older adults. N Engl J Med. 1999;340:14–22.CrossRefPubMed
25.
Lorenz MW, Markus HS, Bots ML, et al. Prediction of clinical cardiovascular events with carotid intima-media thickness: a systematic review and mete-analysis. Circulation. 2007;115:459–67.CrossRefPubMed
26.
Joint committee with the guidelines subcommittee of the Japan Academy of Neurosonology for ultrasonic assessment of carotid artery disease and the subcommittee for research into methods of screening atherosclerotic lesions. Guidelines for ultrasonic assessment of carotid artery disease: Preliminary report. Neurosonology. 2002;15:20–30.
27.
Tanaka H, Nishino M, Ishida M, et al. Progression of carotid atherosclerosis in Japanese patients with coronary artery disease. Stroke. 1992;23:946–51.CrossRefPubMed
28.
Handa N, Matsumoto M, Maeda H, et al. Ischemic stroke events and carotid atherosclerosis: results of the Osaka follow-up study for ultrasonographic assessment of carotid atherosclerosis (the OSACA study). Stroke. 1995;26:17815.CrossRef
29.
Handa N, Okazaki Y, Itoh T, et al. Ultrasonographic characterization of carotid plaque and implications for ischemic cerebrovascular events. Neurosonology. 2000;13:170–4.CrossRef
30.
Sohn DW, Chai IH, Lee DJ, et al. Assessment of mitral annulus velocity by Doppler tissue imaging in the evaluation of left ventricular diastolic function. J Am Coll Cardiol. 1977;30:474–80.CrossRef
31.
Ommen SR, Nishimura RA, Appleton CP, et al. Clinical utility of Doppler echocardiography and tissue Doppler imaging in the estimation of left ventricular filling pressures: a comparative simultaneous Doppler-catheterization study. Circulation. 2000;102:1788–94.CrossRefPubMed
32.
Nagueh SF, Sun H, Kopelen HA, et al. Hemodynamic determinants of the mitral annulus diastolic velocities by tissue Doppler. J Am Coll Cardiol. 2001;37:278–85.CrossRefPubMed
33.
Kasner M, Westermann D, Steendijk P, et al. Utility of Doppler echocardiography and tissue Doppler imaging in the estimation of diastolic function in heart failure with normal ejection fraction: a comparative Doppler-conductance catheterization study. Circulation. 2007;116:637–47.CrossRefPubMed
34.
Tomiyama H, Yamashina A, Arai T, et al. Influences of age and gender on results of noninvasive brachial-ankle pulse wave velocity measurement: a survey of 12,517 subjects. Atherosclerosis. 2003;166:303e9.
35.
Yambe T, Meng X, Hou X, et al. Cardio-ankle vascular index (CAVI) for the monitoring of the atherosclerosis after heart transplantation. Biomed Pharmacother. 2005;59:177e9.
36.
Shirai K, Utino J, Otsuka K, et al. A novel blood pressure independent arterial wall stiffness parameter; cardio-ankle vascular index (CAVI). J Atheroscler Thromb. 2006;13:101e7.CrossRef
37.
Kubozono T, Miyata M, Ueyama K, et al. Clinical significance and reproducibility of new arterial distensibility index. Circ J. 2007;71:89e94.CrossRef
38.
Takaki A, Ogawa H, Wakeyama T, et al. Cardio-ankle vascular index is a new noninvasive parameter of arterial stiffness. Circ J. 2007;71:1710–4.CrossRefPubMed
39.
Okura T, Watanabe S, Kurata M, et al. Relationship between carotid-ankle vascular index (CAVI) and carotid atherosclerosis in patients with essential hypertension. Hypertens Res. 2007;30:335–40.CrossRefPubMed
40.
Nakamura K, Tomaru T, Yamamura S, et al. Cardio-ankle vascular index is a candidate predictor of coronary atherosclerosis. Circ J. 2008;72:598–604.CrossRefPubMed
41.
Ibata J, Sasaki H, Kakimoto T, et al. Cardio-ankle vascular index measures arterial wall stiffness independent of blood pressure. Diabetes Res Clin Pract. 2008;80:265–70.CrossRefPubMed
42.
Kadota K, Takamura N, Aoyagi K, et al. Availability of cardio-ankle vascular index (CAVI) as a screening tool for atherosclerosis. Circ J. 2008;72:304–8.CrossRefPubMed
43.
Izuhara M, Shioji K, Kadota S, et al. Relationship of cardio-ankle vascular index (CAVI) to carotid and coronary arteriosclerosis. Circ J. 2008;72:1762–7.CrossRefPubMed
44.
Takaki A, Ogawa H, Wakeyama T, et al. Cardio-ankle vascular index is superior to brachial-ankle pulse wave velocity as an index of arterial stiffness. Hypertens Res. 2008;31:13747–55.CrossRef
45.
O’Rourke MF. Diastolic heart failure, diastolic left ventricular dysfunction and exercise intolerance. J Am Coll Cardiol. 2001;38:803–5.CrossRefPubMed
46.
Leite-Moreira AF, Correia-Pinto J, Gillebert TC. Afterload induced changes in myocardial relaxation: a mechanism for diastolic dysfunction. Cardiovasc Res. 1999;43:344–53.CrossRefPubMed
47.
Takiuchi S, Kamide K, Miwa Y, et al. Diagnostic value of carotid intima-media thickness and plaque score for predicting target organ damage in patients with essential hypertension. J Hum Hypertens. 2004;18:17–23.CrossRefPubMed
48.
Eren M, Gorgulu S, Uslu N, et al. Relation between aortic stiffness and left ventricular diastolic function in patients with hypertension, diabetes, or both. Heart. 2004;90:37–43.CrossRefPubMedPubMedCentral
49.
Di Bello V, Pedrinelli R, Bianchi M, et al. Ultrasonic myocardial texture in hypertensive mild-to-moderate left ventricular hypertrophy: a videodensitometric study. Am J Hypertens. 1998;11:155–64.CrossRefPubMed
50.
Geroulakos G, O’Gorman DJ, Kalodiki E, et al. The carotid intima-media thickness as a marker of the presence of severe symptomatic coronary artery disease. Eur Heart J. 1994;15:781–5.PubMed
51.
Crouse JR III, Craven TE, Hagaman AP, et al. Association of coronary disease with segment-specific intimal-medial thickening of the extracranial carotid artery. Circulation. 1995;92:1141–7.CrossRefPubMed
52.
Sugo A, Nakajima S, Kurata T, et al. Ultrasonographic assessment of carotid atherosclerosis emphasizing the variety of intimal-medial thickness and the relationship with coronary risk factors. J Cardiol. 1997;30:321–9.PubMed
53.
Hodis HN, Mack WJ, LaBree L, et al. The role of carotid arterial intima-media thickness in predicting clinical coronary events. Ann Intern Med. 1998;128:262–9.CrossRefPubMed
54.
Balbarini A, Buttitta F, Limbruno U, et al. Usefulness of carotid intima-media thickness measurement and peripheral B-mode ultrasound scan in the clinical screening of patients with coronary artery disease. Angiology. 2000;51:269–79.CrossRefPubMed
55.
del Sol AI, Moons KG, Hollander M, et al. Is carotid intima-media thickness useful in cardiovascular disease risk assessment? Rotterdam Study Stroke. 2001;32:1532–8.PubMed
56.
Ogata T, Yasaka M, Yamagishi M, et al. Atherosclerosis found on carotid ultrasonography is associated with atherosclerosis on coronary intravascular ultrasonography. J Ultrasound Med. 2005;24:459–74.
57.
Takiuchi S, Rakugi H, Fujii H, et al. Carotid intima-media thickness is correlated with impairment of coronary flow reserve in hypertensive patients without coronary artery disease. Hypertens Res. 2003;26:945–51.CrossRefPubMed
58.
Dart AM, Kingwell BA. Pulse pressure: a review of mechanisms and clinical relevance. J Am Coll Cardiol. 2001;37:975–84.CrossRefPubMed
59.
London GM, Guerin AP. Influence of arterial pulse and reflected waves on blood pressure and cardiac function. Am Heart J. 1999;138:220–4.CrossRefPubMed
60.
Hittinger L, Shannon RP, Bishop SP, et al. Subendomyocardial exhaustion of blood flow reserve and increased fibrosis in conscious dogs with heart failure. Circ Res. 1989;65:971–80.CrossRefPubMed
61.
Ohtsuka S, Kakihana M, Watanabe H, et al. Chronically decreased aortic distensibility causes deterioration of coronary perfusion during increased left ventricular contraction. J Am Coll Cardiol. 1994;24:1406–14.CrossRefPubMed
62.
Watanabe H, Ohtsuka S, Kakihana M, et al. Coronary circulation in dogs with an experimental decrease in aortic compliance. J Am Coll Cardiol. 1993;21:1497–506.CrossRefPubMed
63.
Eghbali M, Eghbali M, Robinson TF, et al. Collagen accumulation in heart ventricles as a function of growth and aging. Cardiovasc Res. 1989;23:723–9.CrossRefPubMed
64.
Varagic J, Susic D, Frohlich E. Heart, aging, and hypertension. Curr Opin Cardiol. 2001;16:336–41.CrossRefPubMed
65.
Tomanek RJ. Effects of age and exercise on the extent of the myocardial capillary bed. Anat Rec. 1970;167:55–62.CrossRefPubMed
66.
Anversa P, Palackal T, Sonnenblick EH, et al. Myocite cell loss and myocite cellular hyperplasia in the hypertrophied aging rat heart. Circ Res. 1990;67:871–85.CrossRefPubMed
67.
Spagnoli LG, Orlandi A, Mauriello A, et al. Aging and atherosclerosis in the rabbit: 1. distribution, prevalence and morphology of atherosclerotic lesions. Atherosclerosis. 1991;89:11–24.CrossRefPubMed
68.
Nakamura M, Abe S, Kinukawa N. Casual relationship between occlusive lesions of coronary artery and myocardial fibrosis in arteriosclerotic rabbits-differences between cholesterol-fed and heritable hyperlipidemic rabbits. Atherosclerosis. 1996;124:37–47.CrossRefPubMed
69.
Orlandi A, Francesconi A, Marcellini M, et al. Role of ageing and coronary atherosclerosis in the development of cardiac fibrosis in the rabbit. Cardiovasc Res. 2004;64:544–52.CrossRefPubMed
70.
Reed AL, Tanaka A, Sorescu D, et al. Diastolic dysfunction is associated with cardiac fibrosis in the senescence-accelerated mouse. Am J Physiol Heart Circ Physiol. 2011;301:H824–31.CrossRefPubMedPubMedCentral
71.
Kuwahara F, Kai H, Tokuda K, et al. Hypertensive myocardial fibrosis and diastolic dysfunction. Another model of inflammation? Hypertension. 2004;43:739–45.CrossRefPubMed
72.
Brilla CG, Janicki JS, Weber KT. Impaired diastolic function and coronary reserve in genetic hypertension. Role of interstitial fibrosis and medial thickening of intramyocardial coronary arteries. Circ Res. 1991;69:107–15.CrossRefPubMed
73.
Martos R, Baugh J, Ledwidge M, et al. Diastolic heart failure. Evidence of increased myocardial collagen turnover linked to diastolic dysfunction. Circulation. 2007;115:888–95.CrossRefPubMed
74.
Kasner M, Westermann D, Lopez B, et al. Diastolic tissue Doppler indexes correlate with the degree of collagen expression and cross-linking in heart failure and normal ejection fraction. J Am Coll Cardiol. 2011;57:977–85.CrossRefPubMed
75.
Leung MCH, Meredith IT, Cameron JD. Aortic stiffness affects the coronary blood flow response to percutaneous coronary intervention. Am J Physiol. 2006;290:H624–30.
76.
Tsioufis C, Chatzis D, Dimitriadis K, et al. Left ventricular diastolic dysfunction is accompanied by increased aortic stiffness in the early stages of essential hypertension: a TDI approach. J Hypertens. 2005;23:1745–50.CrossRefPubMed
77.
Tsioufis C, Chatzis D, Dimitridis K, et al. Left ventricular dysfunction is accompanied by increased aortic stiffness in the early stages of essential hypertension: a TDI approach. J Hypertens. 2005;23:1745–50.CrossRefPubMed
78.
Litwin SE, Katz SE, Weinberg EO, et al. Serial echocardiographic-Doppler assessment of left ventricular geometry and function in rats with pressure-overload hypertrophy. Chronic angiotensin-converting enzyme inhibition attenuates the transition to heart failure. Circulation. 1995;91:2642–54.CrossRefPubMed
79.
Nicoletti A, Michel JB. Cardiac fibrosis and inflammation: interaction with hemodynamic and hormonal factors. Cardiovasc Res. 1999;41:532–43.CrossRefPubMed
80.
Querejeta R, Varo N, Lopez B, et al. Serum carboxy-terminal propeptide of procollagen type I is a marker of myocardial fibrosis in hypertensive heart disease. Circulation. 2000;101:1729–35.CrossRefPubMed
81.
Kasner M, Westermann D, Lopez B, et al. Diastolic tissue Doppler indexes correlate with the degree of collagen expression and cross-linking in heart failure and normal ejection fraction. J Am Coll Cardiol. 2011;57:977–85.CrossRefPubMed
82.
Tanaka M, Fujiwara H, Onodera T, et al. Quantitative analysis of myocardial fibrosis in normal, hypertensive hearts, and hypertrophic cardiomyopathy. Br Heart J. 1986;55:575–81.CrossRefPubMedPubMedCentral
83.
Anversa P, Palackal T, Sonnenblick EH, et al. Myocyte cell loss and myocyte cellular hyperplasia in the hypertrophied aging rat heart. Circ Res. 1990;67:871–85.CrossRefPubMed
84.
Tomanek RJ, Aydelotte MR, Torry RJ. Remodeling of coronary vessels during aging in purebred beagles. Circ Res. 1991;69:1068–74.CrossRefPubMed
85.
Anversa P, Li P, Sonnenblick EH, Olivetti G. Effects of aging on quantitative structural properties of coronary vasculature and microvasculature in rats. Am J Physiol Heart Circ Physiol. 1994;267:H1062–73.
86.
Venkatesh BA, Volpe GJ, Donekal S, et al. Association of longitudinal changes in left ventricular structure and function with myocardial fibrosis. The Multi-Ethnic study of atherosclerosis study. Hypertension. 2014;64:508–15.CrossRefPubMedCentral
87.
Dhalla NS, Liu X, Panagia V, et al. Subcellular remodeling and heart dysfunction in chronic diabetes. Cardiovasc Res. 1998;40:239–47.CrossRefPubMed
88.
Aronson D. Cross-linking of glycated collagen in the pathogenesis of arterial and myocardial stiffening of aging and diabetes. J Hypertens. 2003;21:3–12.CrossRefPubMed
89.
Fang ZY, Prins JB, Marwick TH. Diabetic cardiomyopathy: evidence, mechanisms and therapeutic implications. Endocr Rev. 2004;25:543–67.CrossRefPubMed
90.
Qureshi G, Brown R, Salciccioli L, et al. Relationship between aortic atherosclerosis and non-invasive measures of arterial stiffness. Atherosclerosis. 2007;195:e190–4.CrossRefPubMed
91.
Mizushige K, Yao L, Noma T, et al. Alteration in left ventricular diastolic filling and accumulation of myocardial collagen at insulin-resistant prediabetic stage of a type II diabetic rat model. Circulation. 2000;101:899–907.CrossRefPubMed
Metadaten
Titel
Carotid atherosclerosis is associated with left ventricular diastolic function
verfasst von
Masahiko Harada
Satoshi Tabako
Publikationsdatum
30.06.2016
Verlag
Springer Japan
Erschienen in
Journal of Echocardiography / Ausgabe 3/2016
Print ISSN: 1349-0222
Elektronische ISSN: 1880-344X
DOI
https://doi.org/10.1007/s12574-016-0296-2

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