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International Ophthalmology

Erschienen in:

30.04.2018 | Case Report

Case report: acute hydrops and spontaneous corneal perforation in a patient with keratoconus treated with colchicine for familial Mediterranean fever

verfasst von: Assaf Hilely, Guy Kleinmann

Erschienen in: International Ophthalmology | Ausgabe 6/2019

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Abstract

Purpose

To report a rare case of spontaneous corneal perforation after hydrops in keratoconus patients who suffer from familial Mediterranean fever and was treated systemically with Colchicine.

Methods

Case report.

Results

We report a case of a 30-year-old male with keratoconus and familial Mediterranean fever treated with colchicine, presented with acute hydrops in his left eye, which progressed to a spontaneous corneal perforation. Attempts to treat the perforation with cyanoacrylate glue failed, and he underwent penetrating keratoplasty with an excellent visual outcome.

Conclusion

Colchicine treatment may have had a role in the pathogenesis of this rare case.

Rabinowitz Y (1998) Keratoconus. Surv Ophthalmol 42:297–319CrossRefPubMed

Tuft SJ, Coster DJ, Buckley RJ (1994) Acute corneal hydrops in keratoconus. Ophthalmology 101:1738–1744CrossRefPubMed

Sharma N, Maharana PK, Jhanji V, Vishal J (2012) Management of acute corneal hydrops in ectatic corneal disorders. Curr Opin Ophthalmol 23:317–323CrossRefPubMed

Tuft SJ, Zabel SJ, Gregory WM (1994) Prognostic factors for the progression of keratoconus. Ophthalmology 101:439–447CrossRefPubMed

Gül A (2014) Treatment of familial mediterranean fever: colchicine and beyond. IMAJ 16:281–284PubMed

Buschke W, Friedenwald JS, Fleischmann W (1943) Studies on the mitotic activity of the corneal epithelium. Methods. The effects of colchicine, ether cocaine and ephedrine. Bull Johns Hopkins Hosp 73:143–167

Wilson SE, Mohan RR, Mohan RR (2001) The corneal wound healing response: cytokine-mediated interaction of the epithelium, stroma, and inflammatory cells. Prog Retin Eye Res 20(5):625–637CrossRefPubMed

Sukeishi A, Isami K, Hiyama H et al (2017) Colchicine alleviates acute postoperative pain but delays wound repair in mice: roles of neutrophils and macrophages. Mol Pain 13:17448069CrossRef

Leibovitch I, Alster Y, Scherrmann JM et al (2003) Colchicine in tear fluid of treated patients with familial mediterranean fever. Cornea 22(3):191–193CrossRefPubMed

10.

Lahoud S, Brownstein S, Laflmme MY (1987) Keratoconus with spontaneous perforation of the cornea. Can J Ophthalmol 22:230–233PubMed

11.

Ingraham HJ, Donnenfeld ED, Perry HD (1991) Keratoconus with spontaneous perforation of the Cornea. Am J Ophthalmol 109(12):1651–1652

12.

Nicoli C, Wainsztein R, Trotta LP (1999) Corneal topography of spontaneous perforation of acute hydrops in keratoconus. J Cataract Refract Surg 25(6):871–872CrossRefPubMed

13.

McMonnies CW (2014) Mechanisms for acute corneal hydrops and perforation. Eye & Contact Lens: Science & Clinical Practice 40(4):257–264CrossRef

14.

Gupta C, Tanaka TS, Elner VM et al (2015) Acute hydrops with corneal perforation in post-LASIK ectasia. Cornea 34(1):99–100CrossRefPubMed

15.

Chen CL, Tai MC, Chen JT et al (2015) Acute corneal hydrops with perforation after LASIK-associated keratectasia. Clin Exp Ophthalmol 35(1):62–65CrossRef

16.

Toriyama K, Inoue T, Suzuki T et al (2013) Spontaneous bleb formation in a presumed pellucid marginal corneal degeneration with acute hydrops. Cornea 32(6):839–841CrossRefPubMed

17.

Dantas PE, Nishiwaki-Dantas MC (2004) Spontaneous bilateral corneal perforation of acute hydrops in keratoconus. Eye Contact Lens 30(1):40–41CrossRefPubMed

18.

Lam FC, Bhatt PR, Ramaesh K (2011) Spontaneous perforation of the cornea in mild keratoconus. Cornea 30(1):103–104CrossRefPubMed

19.

Mostafavi D, Chu DS (2010) Two cases of keratoconus associated with spontaneous corneal perforation. Cornea 29(7):825–827CrossRefPubMed

Titel: Case report: acute hydrops and spontaneous corneal perforation in a patient with keratoconus treated with colchicine for familial Mediterranean fever
verfasst von: Assaf Hilely
Guy Kleinmann
Publikationsdatum: 30.04.2018
Verlag: Springer Netherlands
Erschienen in: International Ophthalmology / Ausgabe 6/2019
Print ISSN: 0165-5701
Elektronische ISSN: 1573-2630
DOI: https://doi.org/10.1007/s10792-018-0924-0

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Springer Medizin

Case report: acute hydrops and spontaneous corneal perforation in a patient with keratoconus treated with colchicine for familial Mediterranean fever

Abstract

Purpose

Methods

Results

Conclusion

Neu im Fachgebiet Augenheilkunde

Ophthalmika in der Schwangerschaft

Operative Therapie und Keimnachweis bei endogener Endophthalmitis

Bakterielle endogene Endophthalmitis

So erreichen Sie eine bestmögliche Wundheilung der Kornea

Update Augenheilkunde

Springer Medizin

Abstract

Purpose

Methods

Results

Conclusion

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