Introduction
Methods
Data sources
Instrumental variable selection
Statistical analysis
Results
Causal effect of gut microbiota on ICP
Bacterial taxa (exposure) | MR method | No. SNP | Beta | SE | OR | 95%CI | P-value |
---|---|---|---|---|---|---|---|
Phylum Tenericutes | ML | 12 | 0.524 | 0.232 | 1.689 | 1.071–2.663 | 0.024* |
MR-Egger | 12 | -0.204 | 0.721 | 0.815 | 0.198–3.351 | 0.784 | |
Weighted median | 12 | 0.470 | 0.305 | 1.601 | 0.880–2.911 | 0.123 | |
IVW | 12 | 0.513 | 0.226 | 1.670 | 1.073–2.598 | 0.023* | |
Weighted mode | 12 | 0.430 | 0.407 | 1.537 | 0.692–3.411 | 0.316 | |
Class Bacteroidia | ML | 14 | 0.518 | 0.243 | 1.678 | 1.042–2.701 | 0.033* |
MR-Egger | 14 | 0.200 | 0.487 | 1.222 | 0.470–3.175 | 0.688 | |
Weighted median | 14 | 0.487 | 0.343 | 1.628 | 0.831–3.189 | 0.156 | |
IVW | 14 | 0.497 | 0.238 | 1.644 | 1.031–2.622 | 0.037* | |
Weighted mode | 14 | 0.740 | 0.480 | 2.096 | 0.818–5.368 | 0.147 | |
Class Mollicutes | ML | 12 | 0.524 | 0.232 | 1.689 | 1.071–2.663 | 0.024* |
MR-Egger | 12 | -0.204 | 0.721 | 0.815 | 0.198–3.351 | 0.784 | |
Weighted median | 12 | 0.470 | 0.302 | 1.601 | 0.886–2.892 | 0.119 | |
IVW | 12 | 0.513 | 0.226 | 1.670 | 1.073–2.598 | 0.023* | |
Weighted mode | 12 | 0.430 | 0.424 | 1.537 | 0.670–3.525 | 0.335 | |
Order Bacteroidales | ML | 14 | 0.518 | 0.243 | 1.678 | 1.042–2.701 | 0.033* |
MR-Egger | 14 | 0.200 | 0.487 | 1.222 | 0.470–3.175 | 0.688 | |
Weighted median | 14 | 0.487 | 0.328 | 1.628 | 0.856–3.093 | 0.137 | |
IVW | 14 | 0.497 | 0.238 | 1.644 | 1.031–2.622 | 0.037* | |
Weighted mode | 14 | 0.740 | 0.500 | 2.096 | 0.787–5.581 | 0.163 | |
Genus Dialister | ML | 11 | -0.600 | 0.245 | 0.549 | 0.340–0.886 | 0.014* |
MR-Egger | 11 | -2.413 | 1.038 | 0.090 | 0.012–0.684 | 0.045* | |
Weighted median | 11 | -0.739 | 0.360 | 0.478 | 0.236–0.977 | 0.040* | |
IVW | 11 | -0.576 | 0.282 | 0.562 | 0.323–0.977 | 0.041* | |
Weighted mode | 11 | -1.027 | 0.644 | 0.358 | 0.101–1.264 | 0.141 | |
Genus Erysipelatoclostridium | ML | 15 | -0.356 | 0.183 | 0.701 | 0.490–1.002 | 0.051 |
MR-Egger | 15 | -0.899 | 0.703 | 0.407 | 0.103–1.613 | 0.223 | |
Weighted median | 15 | -0.270 | 0.242 | 0.764 | 0.475–1.226 | 0.264 | |
IVW | 15 | -0.363 | 0.179 | 0.695 | 0.490–0.987 | 0.042* | |
Weighted mode | 15 | -0.253 | 0.385 | 0.776 | 0.365–1.650 | 0.521 | |
Genus Eubacterium (brachy group) | ML | 10 | -0.431 | 0.152 | 0.650 | 0.483–0.875 | 0.005* |
MR-Egger | 10 | -0.322 | 0.608 | 0.725 | 0.220–2.387 | 0.611 | |
Weighted median | 10 | -0.490 | 0.210 | 0.613 | 0.406–0.924 | 0.019* | |
IVW | 10 | -0.413 | 0.146 | 0.661 | 0.497–0.880 | 0.005* | |
Weighted mode | 10 | -0.662 | 0.371 | 0.516 | 0.249–1.067 | 0.108 | |
Genus Eubacterium (hallii group) | ML | 16 | -0.403 | 0.202 | 0.668 | 0.450–0.993 | 0.046* |
MR-Egger | 16 | -0.217 | 0.406 | 0.805 | 0.363–1.785 | 0.601 | |
Weighted median | 16 | -0.472 | 0.265 | 0.624 | 0.371–1.049 | 0.075 | |
IVW | 16 | -0.410 | 0.197 | 0.664 | 0.451–0.977 | 0.037* | |
Weighted mode | 16 | -0.528 | 0.362 | 0.590 | 0.290–1.198 | 0.165 | |
Genus Holdemania | ML | 14 | -0.523 | 0.185 | 0.592 | 0.412–0.852 | 0.005* |
MR-Egger | 14 | 0.121 | 0.532 | 1.129 | 0.398-3.200 | 0.823 | |
Weighted median | 14 | -0.507 | 0.249 | 0.602 | 0.370–0.981 | 0.042* | |
IVW | 14 | -0.528 | 0.180 | 0.590 | 0.414–0.840 | 0.003* | |
Weighted mode | 14 | -0.569 | 0.398 | 0.566 | 0.260–1.234 | 0.176 | |
Genus Ruminococcus (torques group) | ML | 9 | -0.792 | 0.339 | 0.453 | 0.233–0.880 | 0.019* |
MR-Egger | 9 | 0.250 | 1.044 | 1.284 | 0.166–9.937 | 0.818 | |
Weighted median | 9 | -0.739 | 0.443 | 0.478 | 0.200-1.139 | 0.096 | |
IVW | 9 | -0.804 | 0.329 | 0.448 | 0.235–0.854 | 0.015* | |
Weighted mode | 9 | -0.869 | 0.614 | 0.419 | 0.126–1.397 | 0.195 | |
Genus Veillonella | ML | 6 | -0.681 | 0.293 | 0.506 | 0.285–0.898 | 0.020* |
MR-Egger | 6 | -1.060 | 2.233 | 0.346 | 0.004–27.561 | 0.660 | |
Weighted median | 6 | -0.791 | 0.352 | 0.454 | 0.227–0.905 | 0.025* | |
IVW | 6 | -0.668 | 0.283 | 0.513 | 0.294–0.893 | 0.018* | |
Weighted mode | 6 | -0.870 | 0.492 | 0.419 | 0.160–1.100 | 0.137 |