1 Introduction
2 Methods
2.1 Study design
2.2 Data sources
Data source | Phenotype | Sample size | Cases | Population | Adjustment | PubMed ID/website |
---|---|---|---|---|---|---|
MiBioGen consortium | Gut microbial | 14,306 | – | European | Age, sex, technical covariates, and genetic principal components | 33462485 |
PRACTICAL | Prostate cancer | 140,254 | 79,148 | European | Age, sex | 29892016 |
FinnGen | Prostate cancer | 133,164 | 13,216 | European | Age, sex |
2.3 Instrument selection
2.4 Statistical analyses
3 Results
3.1 Selection of instrumental variables
3.2 MR analyses
Data source | Classification | Bacterial taxas | Heterogeneity | Horizontal pleiotropy | |||||
---|---|---|---|---|---|---|---|---|---|
I2 (%) | IVW | Egger intercept | SE | P-value | MR-PRESSO global test p | ||||
Cochran’s Q | P-value | ||||||||
PRACTICAL | class | Alphaproteobacteria id.2379 | 26.131 | 8.122 | 0.229 | 0.005 | 0.020 | 0.780 | 0.312 |
PRACTICAL | family | Porphyromonadaceae id.943 | 25.235 | 9.362 | 0.227 | − 0.019 | 0.016 | 0.276 | 0.256 |
PRACTICAL | genus | Adlercreutzia id.812 | 0 | 6.638 | 0.467 | − 0.004 | 0.017 | 0.825 | 0.489 |
PRACTICAL | genus | Eubacterium fissicatena group id.14373 | 46.172 | 14.862 | 0.061 | − 0.018 | 0.026 | 0.503 | 0.083 |
PRACTICAL | genus | Eubacterium hallii group id.11338 | 0 | 11.601 | 0.638 | − 0.005 | 0.006 | 0.380 | 0.630 |
PRACTICAL | genus | Odoribacter id.952 | 43.093 | 10.543 | 0.103 | 0.002 | 0.019 | 0.902 | 0.149 |
PRACTICAL | genus | Roseburia id.2012 | 28.276 | 16.730 | 0.160 | − 0.002 | 0.011 | 0.841 | 0.180 |
PRACTICAL | genus | Holdemania id.2157 | 23.979 | 17.100 | 0.194 | − 0.007 | 0.010 | 0.494 | 0.212 |
PRACTICAL | genus | Flavonifractor id.2059 | 49.970 | 7.995 | 0.091 | − 0.014 | 0.030 | 0.661 | 0.153 |
PRACTICAL | genus | Allisonella id.2174 | 18.176 | 6.110 | 0.295 | 0.003 | 0.028 | 0.905 | 0.353 |
PRACTICAL | genus | Dorea id.1997 | 0 | 5.752 | 0.674 | 0.003 | 0.010 | 0.758 | 0.707 |
PRACTICAL | genus | Coprobacter id.949 | 0 | 7.946 | 0.634 | − 0.012 | 0.011 | 0.305 | 0.675 |
PRACTICAL | order | Rhodospirillales id.2667 | 15.006 | 15.295 | 0.289 | 0.021 | 0.014 | 0.149 | 0.323 |
FinnGen | class | Alphaproteobacteria id.2379 | 0 | 2.982 | 0.702 | − 0.005 | 0.026 | 0.836 | 0.718 |
FinnGen | class | Porphyromonadaceae id.943 | 0 | 1.454 | 0.993 | 0.003 | 0.026 | 0.904 | 0.994 |
FinnGen | genus | Adlercreutzia id.812 | 0 | 5.722 | 0.572 | 0.005 | 0.027 | 0.838 | 0.602 |
FinnGen | genus | Eubacterium fissicatena group id.14373 | 0 | 6.353 | 0.607 | < 0.001 | 0.030 | 0.999 | 0.615 |
FinnGen | genus | Eubacterium hallii group id.11338 | 5.595 | 13.770 | 0.390 | 0.004 | 0.011 | 0.699 | 0.432 |
FinnGen | genus | Odoribacter id.952 | 0 | 3.969 | 0.680 | < 0.001 | 0.021 | 0.977 | 0.738 |
FinnGen | genus | Roseburia id.2012 | 0 | 4.406 | 0.818 | − 0.026 | 0.019 | 0.204 | 0.789 |
FinnGen | genus | Holdemania id.2157 | 4.738 | 13.646 | 0.399 | 0.002 | 0.016 | 0.898 | 0.433 |
FinnGen | genus | Flavonifractor id.2059 | 52.628 | 8.443 | 0.076 | 0.012 | 0.052 | 0.824 | 0.111 |
FinnGen | genus | Allisonella id.2174 | 19.936 | 8.743 | 0.271 | 0.021 | 0.047 | 0.666 | 0.294 |
FinnGen | genus | Dorea id.1997 | 0 | 5.767 | 0.449 | 0.017 | 0.017 | 0.371 | 0.475 |
FinnGen | genus | Coprobacter id.949 | 0 | 2.601 | 0.856 | − 0.017 | 0.041 | 0.696 | 0.846 |
FinnGen | order | Rhodospirillales id.2667 | 0 | 5.500 | 0.939 | 0.010 | 0.020 | 0.622 | 0.938 |