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17.10.2018 | Case Report - Brain Tumors

Cavernous malformations are rare sequelae of stereotactic radiosurgery for brain metastases

verfasst von: Kira Seiger, Arjun V. Pendharkar, Peyman Samghabadi, Steven D. Chang, Nam Cho, Clara Y. H. Choi, Candace Wang, Melanie Hayden Gephart, Scott G. Soltys

Erschienen in: Acta Neurochirurgica | Ausgabe 1/2019

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Abstract

The development of cavernous malformations many years following conventionally fractionated brain irradiation is well recognized and commonly reported. However, cavernous malformation induction following stereotactic radiosurgery (SRS) is largely unreported. Herein, we describe two cases of cavernous malformation formation years following SRS for brain metastases. A 20-year-old woman with breast cancer brain metastases received treatment with whole brain radiotherapy (WBRT), then salvage SRS 1.4 years later for progression of a previously treated metastasis. This lesion treated with SRS had hemorrhagic enlargement 3.0 years after SRS. Resection revealed a cavernous malformation. A 25-year-old woman had SRS for a brain metastasis from papillary thyroid carcinoma. Resection of a progressive, hemorrhagic lesion within the SRS field 2 years later revealed both recurrent carcinoma as well as cavernous malformation. As patients with brain metastases live longer following SRS, our cases highlight that the differential diagnosis of an enlarging enhancing lesion within a previous SRS field includes not only cerebral necrosis and tumor progression but also cavernous malformation induction.

American Society for Radiation Oncology: Choosing Wisely 2014. https://www.astro.org/Patient-Care/Patient-Education/2014-Choosing-Wisely-List/. Accessed 1 Nov 2017

Barnett GH, Linskey ME, Adler JR, Cozzens JW, Friedman WA, Heilbrun MP, Lunsford LD, Schulder M, Sloan AE, American Association of Neurological S, Congress of Neurological Surgeons Washington Committee Stereotactic Radiosurgery Task F (2007) Stereotactic radiosurgery--an organized neurosurgery-sanctioned definition. J Neurosurg 106:1–5. https://doi.org/10.3171/jns.2007.106.1.1 CrossRefPubMed

Cha YJ, Nahm JH, Ko JE, Shin HJ, Chang JH, Cho NH, Kim SH (2015) Pathological evaluation of radiation-induced vascular lesions of the brain: distinct from de novo cavernous hemangioma. Yonsei Med J 56:1714–1720. https://doi.org/10.3349/ymj.2015.56.6.1714 CrossRefPubMedPubMedCentral

Ciricillo SF, Cogen PH, Edwards MS (1994) Pediatric cryptic vascular malformations: presentation, diagnosis and treatment. Pediatr Neurosurg 20:137–147CrossRefPubMed

Crocker M, deSouza R, Epaliyanage P, Bodi I, Deasy N, Selway R (2007) Masson’s tumour in the right parietal lobe after stereotactic radiosurgery for cerebellar AVM: case report and review. Clin Neurol Neurosurg 109:811–815. https://doi.org/10.1016/j.clineuro.2007.07.005 CrossRefPubMed

Di Giannatale A, Morana G, Rossi A, Cama A, Bertoluzzo L, Barra S, Nozza P, Milanaccio C, Consales A, Garre ML (2014) Natural history of cavernous malformations in children with brain tumors treated with radiotherapy and chemotherapy. J Neuro-Oncol 117:311–320. https://doi.org/10.1007/s11060-014-1390-9 CrossRef

Fujimoto D, von Eyben R, Gibbs IC, Chang SD, Li G, Harsh GR, Hancock S, Fischbein N, Soltys SG (2018) Imaging changes over 18 months following stereotactic radiosurgery for brain metastases: both late radiation necrosis and tumor progression can occur. J Neuro-Oncol 136:207–212. https://doi.org/10.1007/s11060-017-2647-x CrossRef

Gaspar LE, Scott C, Murray K, Curran W (2000) Validation of the RTOG recursive partitioning analysis (RPA) classification for brain metastases. Int J Radiat Oncol Biol Phys 47:1001–1006CrossRefPubMed

Gross BA, Batjer HH, Awad IA, Bendok BR (2009) Brainstem cavernous malformations. Neurosurgery 64:E805–E818; discussion E818. https://doi.org/10.1227/01.NEU.0000343668.44288.18 CrossRefPubMed

10.

Heckl S, Aschoff A, Kunze S (2002) Radiation-induced cavernous hemangiomas of the brain: a late effect predominantly in children. Cancer 94:3285–3291. https://doi.org/10.1002/cncr.10596 CrossRefPubMed

11.

Iwai Y, Yamanaka K, Yoshimura M (2007) Intracerebral cavernous malformation induced by radiosurgery. Case report. Neurol Med Chir (Tokyo) 47:171–173CrossRef

12.

Karamchandani J, Vogel H, Fischbein N, Gibbs I, Edwards MS, Griffith H (2012) Extravascular papillary endothelial hyperplasia mimicking neoplasm after radiosurgery: case report. Neurosurgery 70:E1043–E1048; discussion E1048. https://doi.org/10.1227/NEU.0b013e31822e81f9 CrossRefPubMed

13.

Keezer MR, Del Maestro R (2009) Radiation-induced cavernous hemangiomas: case report and literature review. Can J Neurol Sci 36:303–310CrossRefPubMed

14.

Kleinschmidt-DeMasters BK, Lillehei KO (2016) Radiation-induced cerebral vascular “malformations” at biopsy. J Neuropathol Exp Neurol. https://doi.org/10.1093/jnen/nlw085

15.

Koike T, Yanagimachi N, Ishiguro H, Yabe H, Yabe M, Morimoto T, Shimizu T, Takakura H, Kato S (2012) High incidence of radiation-induced cavernous hemangioma in long-term survivors who underwent hematopoietic stem cell transplantation with radiation therapy during childhood or adolescence. Biol Blood Marrow Transplant 18:1090–1098. https://doi.org/10.1016/j.bbmt.2011.12.582 CrossRefPubMed

16.

Kurita H, Sasaki T, Kawamoto S, Taniguchi M, Kitanaka C, Nakaguchi H, Kirino T (1996) Chronic encapsulated expanding hematoma in association with gamma knife stereotactic radiosurgery for a cerebral arteriovenous malformation. Case report. J Neurosurg 84:874–878. https://doi.org/10.3171/jns.1996.84.5.0874 CrossRefPubMed

17.

Larson JJ, Ball WS, Bove KE, Crone KR, Tew JM Jr (1998) Formation of intracerebral cavernous malformations after radiation treatment for central nervous system neoplasia in children. J Neurosurg 88:51–56. https://doi.org/10.3171/jns.1998.88.1.0051 CrossRefPubMed

18.

Motegi H, Kuroda S, Ishii N, Aoyama H, Terae S, Shirato H, Iwasaki Y (2008) De novo formation of cavernoma after radiosurgery for adult cerebral arteriovenous malformation--case report. Neurol Med Chir (Tokyo) 48:397–400CrossRef

19.

Murakami K, Jokura H, Kawagishi J, Watanabe M, Tominaga T (2011) Development of intratumoral cyst or extratumoral arachnoid cyst in intracranial schwannomas following gamma knife radiosurgery. Acta Neurochir 153:1201–1209. https://doi.org/10.1007/s00701-011-0972-y CrossRefPubMed

20.

Nimjee SM, Powers CJ, Bulsara KR (2006) Review of the literature on de novo formation of cavernous malformations of the central nervous system after radiation therapy. Neurosurg Focus 21:e4PubMed

21.

Pozzati E, Giuliani G, Gaist G, Piazza G, Vergoni G (1986) Chronic expanding intracerebral hematoma. J Neurosurg 65:611–614. https://doi.org/10.3171/jns.1986.65.5.0611 CrossRefPubMed

22.

Pozzati E, Acciarri N, Tognetti F, Marliani F, Giangaspero F (1996) Growth, subsequent bleeding, and de novo appearance of cerebral cavernous angiomas. Neurosurgery 38:662–669 discussion 669-670CrossRefPubMed

23.

Rigamonti D, Hadley MN, Drayer BP, Johnson PC, Hoenig-Rigamonti K, Knight JT, Spetzler RF (1988) Cerebral cavernous malformations. Incidence and familial occurrence. N Engl J Med 319:343–347. https://doi.org/10.1056/NEJM198808113190605 CrossRefPubMed

24.

Sasagawa Y, Akai T, Itou S, Iizuka H (2009) Gamma knife radiosurgery-induced cavernous hemangioma: case report. Neurosurgery 64:E1006–E1007; discussion E1007. https://doi.org/10.1227/01.NEU.0000344005.23146.CC CrossRefPubMed

25.

Shultz DB, Modlin LA, Jayachandran P, Von Eyben R, Gibbs IC, Choi CY, Chang SD, GRt H, Li G, Adler JR, Hancock SL, Soltys SG (2015) Repeat courses of stereotactic radiosurgery (SRS), deferring whole-brain irradiation, for new brain metastases after initial SRS. Int J Radiat Oncol Biol Phys 92:993–999. https://doi.org/10.1016/j.ijrobp.2015.04.036 CrossRefPubMed

26.

Smith ER, Scott RM (2010) Cavernous malformations. Neurosurg Clin N Am 21:483–490. https://doi.org/10.1016/j.nec.2010.03.003 CrossRefPubMed

27.

Sneed PK, Mendez J, Vemer-van den Hoek JG, Seymour ZA, Ma L, Molinaro AM, Fogh SE, Nakamura JL, McDermott MW (2015) Adverse radiation effect after stereotactic radiosurgery for brain metastases: incidence, time course, and risk factors. J Neurosurg 123:373–386. https://doi.org/10.3171/2014.10.JNS141610 CrossRefPubMed

28.

Sperduto PW, Kased N, Roberge D, Xu Z, Shanley R, Luo X, Sneed PK, Chao ST, Weil RJ, Suh J, Bhatt A, Jensen AW, Brown PD, Shih HA, Kirkpatrick J, Gaspar LE, Fiveash JB, Chiang V, Knisely JP, Sperduto CM, Lin N, Mehta M (2012) Summary report on the graded prognostic assessment: an accurate and facile diagnosis-specific tool to estimate survival for patients with brain metastases. J Clin Oncol 30:419–425. https://doi.org/10.1200/JCO.2011.38.0527 CrossRefPubMed

29.

Takei J, Tanaka T, Yamamoto Y, Teshigawara A, Tochigi S, Hasegawa Y, Murayama Y (2016) Chronic encapsulated expanding thalamic hematoma associated with obstructive hydrocephalus following radiosurgery for a cerebral arteriovenous malformation: a case report and literature review. Case Rep Neurol Med 2016:5130820. https://doi.org/10.1155/2016/5130820 CrossRefPubMedPubMedCentral

30.

Wang X, Hui XH, Liu JP, Mao Q (2012) Radiation-induced cavernous malformation at the site of arteriovenous malformation following gamma knife radiosurgery: case report. Clin Neurol Neurosurg 114:1287–1289. https://doi.org/10.1016/j.clineuro.2012.03.005 CrossRefPubMed

31.

Yamamoto M, Serizawa T, Shuto T, Akabane A, Higuchi Y, Kawagishi J, Yamanaka K, Sato Y, Jokura H, Yomo S, Nagano O, Kenai H, Moriki A, Suzuki S, Kida Y, Iwai Y, Hayashi M, Onishi H, Gondo M, Sato M, Akimitsu T, Kubo K, Kikuchi Y, Shibasaki T, Goto T, Takanashi M, Mori Y, Takakura K, Saeki N, Kunieda E, Aoyama H, Momoshima S, Tsuchiya K (2014) Stereotactic radiosurgery for patients with multiple brain metastases (JLGK0901): a multi-institutional prospective observational study. Lancet Oncol 15:387–395. https://doi.org/10.1016/S1470-2045(14)70061-0 CrossRefPubMed

32.

Yeon JY, Suh YL, Kim JH, Lee JI (2010) Development of de novo cavernous hemangioma after radiosurgery for cavernous hemangioma. J Korean Neurosurg Soc 48:532–533. https://doi.org/10.3340/jkns.2010.48.6.532 CrossRefPubMedPubMedCentral

Titel: Cavernous malformations are rare sequelae of stereotactic radiosurgery for brain metastases
verfasst von: Kira Seiger
Arjun V. Pendharkar
Peyman Samghabadi
Steven D. Chang
Nam Cho
Clara Y. H. Choi
Candace Wang
Melanie Hayden Gephart
Scott G. Soltys
Publikationsdatum: 17.10.2018
Verlag: Springer Vienna
Erschienen in: Acta Neurochirurgica / Ausgabe 1/2019
Print ISSN: 0001-6268
Elektronische ISSN: 0942-0940
DOI: https://doi.org/10.1007/s00701-018-3701-y

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