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Digestive Diseases and Sciences

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05.06.2020 | CURRENT CLINICAL CONTROVERSY

Celiac Disease Screening for High-Risk Groups: Are We Doing It Right?

verfasst von: Dennis Kumral, Sana Syed

Erschienen in: Digestive Diseases and Sciences | Ausgabe 8/2020

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Abstract

Celiac disease (CD) is an immune-mediated enteropathy triggered by dietary ingestion of gluten in genetically susceptible patients. CD is often diagnosed by a “case-finding” approach of symptomatic patients. In recent times, the diagnostic paradigm has shifted to investigate patients who may be asymptomatic, but are at high risk of developing CD due to shared genetic susceptibilities. These high-risk groups include first-degree relatives of CD patients and patients with Type 1 diabetes mellitus, autoimmune thyroid disease, Down’s syndrome, and Turner syndrome. Moreover, CD is often diagnosed as the cause of iron deficiency anemia or unexplained chronic diarrhea. Although screening for CD with serological tests is not recommended for the general population, it should be considered in these special populations. In this review, we explore screening for CD among high-risk groups in light of recent research and development in the CD arena.

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Titel: Celiac Disease Screening for High-Risk Groups: Are We Doing It Right?
verfasst von: Dennis Kumral
Sana Syed
Publikationsdatum: 05.06.2020
Verlag: Springer US
Erschienen in: Digestive Diseases and Sciences / Ausgabe 8/2020
Print ISSN: 0163-2116
Elektronische ISSN: 1573-2568
DOI: https://doi.org/10.1007/s10620-020-06352-w

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