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Netherlands Heart Journal
Erschienen in: Netherlands Heart Journal 5/2009

01.05.2009 | review article

Cell therapy for ischaemic heart disease: focus on the role of resident cardiac stem cells

verfasst von: S. A. J. Chamuleau, K. R. Vrijsen, D. G. Rokosh, X. L. Tang, J. J. Piek, R. Bolli

Erschienen in: Netherlands Heart Journal | Ausgabe 5/2009

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Abstract

Myocardial infarction results in loss of cardiomyocytes, scar formation, ventricular remodelling, and eventually heart failure. In recent years, cell therapy has emerged as a potential new strategy for patients with ischaemic heart disease. This includes embryonic and bone marrow derived stem cells. Recent clinical studies showed ostensibly conflicting results of intracoronary infusion of autologous bone marrow derived stem cells in patients with acute or chronic myocardial infarction. Anyway, these results have stimulated additional clinical and pre-clinical studies to further enhance the beneficial effects of stem cell therapy. Recently, the existence of cardiac stem cells that reside in the heart itself was demonstrated. Their discovery has sparked intense hope for myocardial regeneration with cells that are obtained from the heart itself and are thereby inherently programmed to reconstitute cardiac tissue. These cells can be detected by several surface markers (e.g. c-kit, Sca-1, MDR1, Isl-1). Both in vitro and in vivo differentiation into cardiomyocytes, endothelial cells and vascular smooth muscle cells has been demonstrated, and animal studies showed promising results on improvement of left ventricular function. This review will discuss current views regarding the feasibility of cardiac repair, and focus on the potential role of the resident cardiac stem and progenitor cells. (Neth Heart J 2009;17:199–207.)
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Metadaten
Titel
Cell therapy for ischaemic heart disease: focus on the role of resident cardiac stem cells
verfasst von
S. A. J. Chamuleau
K. R. Vrijsen
D. G. Rokosh
X. L. Tang
J. J. Piek
R. Bolli
Publikationsdatum
01.05.2009
Verlag
Bohn Stafleu van Loghum
Erschienen in
Netherlands Heart Journal / Ausgabe 5/2009
Print ISSN: 1568-5888
Elektronische ISSN: 1876-6250
DOI
https://doi.org/10.1007/BF03086247

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