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20.06.2022 | Original Article

Cerebral blood flow alterations specific to freezing of gait in Parkinson’s disease

verfasst von: Shangpei Wang, Tong Wu, Chuan Li, Tieyu Wu, Yinfeng Qian, Cuiping Ren, Yan Qin, Juan Li, Xianzhou Chu, Xianwen Chen, Yongqiang Yu

Erschienen in: Neurological Sciences | Ausgabe 9/2022

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Abstract

Background

Freezing of gait (FOG) have been associated with deficits in the cortico-basal ganglia-thalamic network. However, the resting-state cerebral blood flow (CBF) alterations specific to FOG in Parkinson’s disease (PD) remain unknown.

Methods

In total, sixty PD individuals, including 30 PD with FOG (PD-FOG) and 30 PD without FOG (PD-NFOG), and 30 healthy controls (HC) underwent arterial spin labeling magnetic resonance image. The CBF were voxel-wise compared among the three groups and validated in a different cohort of PD-FOG and PD-NFOG.

Results

The results revealed that patients with PD-FOG had increased CBF in bilateral thalamus and the left caudate nucleus and decreased CBF in the left inferior parietal cortex compared to patients with PD-NFOG. The inter-group differences of CBF between PD-FOG and PD-NFOG was confirmed in a different cohort in the validation analysis. Moreover, the CBF in left caudate nucleus was positively correlated with severity of FOG in PD-FOG patients.

Conclusions

Perfusion alterations in both cortical and subcortical regions in the cortico-basal ganglia-thalamic network are related to the development of FOG in PD patients.

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Titel: Cerebral blood flow alterations specific to freezing of gait in Parkinson’s disease
verfasst von: Shangpei Wang
Tong Wu
Chuan Li
Tieyu Wu
Yinfeng Qian
Cuiping Ren
Yan Qin
Juan Li
Xianzhou Chu
Xianwen Chen
Yongqiang Yu
Publikationsdatum: 20.06.2022
Verlag: Springer International Publishing
Erschienen in: Neurological Sciences / Ausgabe 9/2022
Print ISSN: 1590-1874
Elektronische ISSN: 1590-3478
DOI: https://doi.org/10.1007/s10072-022-06205-6

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