Background
Methods
Study subjects
Routine ultrasound
Cerebral 3D-PD
MH protocol
Statistics
Results
Population characteristics
Foetus younger than 28 weeks GA (group I) | P | Foetus older than 28 weeks GA (group II) | P | |||
---|---|---|---|---|---|---|
Normal (n = 12) | Borderline small left heart (n = 12) | Normal (n = 16) | Borderline small left heart (n = 16) | |||
Maternal age (years) | 29 ± 6 | 28 ± 6 | 0.75 | 30 ± 5 | 29 ± 6 | 0.53 |
Nulliparous, n (%) | 6 | 8 | 0.68 | 8 | 7 | 1.0 |
AR pregnancy | 2 | 5 | 0.37 | 1 | 4 | 0.3 |
GA at diagnosis (weeks) | 25.8 ± 1.2 | 25.8 ± 1.2 | 1.00 | 32.5 ± 2.5 | 32.5 ± 2.5 | 1.00 |
EFW at diagnosis (g) | 832 ± 121 | 868 ± 152 | 0.53 | 1993 ± 525 | 2000 ± 533 | 0.97 |
GA at birth (weeks) | 39.0 ± 1.0 | 38.2 ± 0.8 | 0.06 | 40.2 ± 0.8 | 39.6 ± 0.8 | 0.05 |
Weight at birth (g) | 3448 ± 259 | 3033 ± 248 | 0.001 | 3575 ± 159 | 3422 ± 259 | 0.05 |
BPD (mm) | 64.9 ± 0.5 | 64.8 ± 0.4 | 0.95 | 83.5 ± 0.6 | 81.4 ± 0.5 | 0.28 |
HC (mm) | 238.0 ± 1.4 | 236.5 ± 1.5 | 0.80 | 293.4 ± 1.7 | 283.1 ± 1.5 | 0.08 |
FHR (bpm) | 152 ± 7 | 154 ± 8 | 0.78 | 154 ± 6 | 154 ± 7 | 0.96 |
MCA-PI | 1.62 ± 0.19 | 1.61 ± 0.19 | 0.92 | 1.79 ± 0.22 | 1.44 ± 0.27 | < 0.001 |
UA-PI | 1.19 ± 0.22 | 1.14 ± 0.13 | 0.47 | 0.96 ± 0.22 | 1.11 ± 0.19 | 0.05 |
MV Z-score | 0.00 ± 0.19 | −2.24 ± 0.27 | < 0.001 | − 0.02 ± 0.40 | − 2.23 ± 0.28 | < 0.001 |
TV Z-score | −0.05 ± 0.24 | 0.15 ± 0.29 | 0.07 | 0.03 ± 0.25 | 0.12 ± 0.36 | 0.43 |
AV Z-score | −0.06 ± 0.39 | −2.33 ± 0.33 | < 0.001 | −0.02 ± 0.32 | −2.28 ± 0.24 | < 0.001 |
PV Z-score | −0.06 ± 0.28 | 0.06 ± 0.29 | 0.34 | −0.06 ± 0.38 | 0.08 ± 0.49 | 0.56 |
VI | 1.72 ± 0.29 | 1.70 ± 0.26 | 0.81 | 2.00 ± 0.34 | 3.19 ± 0.87 | < 0.001 |
FI | 33.00 ± 4.29 | 33.28 ± 3.85 | 0.56 | 37.52 ± 2.86 | 56.91 ± 9.19 | < 0.001 |
VFI | 0.60 ± 0.22 | 0.62 ± 0.18 | 0.82 | 0.84 ± 0.16 | 1.30 ± 0.33 | < 0.001 |
CCOi (mL/min/kg) | 427.52 ± 73.73 | 436.68 ± 66.33 | 0.75 | 501.42 ± 79.56 | 462.88 ± 74.42 | 0.17 |
Cerebral flow perfusion during 3 phases
Potential factors
Change in cerebral perfusion | Independent variables | R2 | Beta | P |
---|---|---|---|---|
ΔFI | Baseline MCA-PI | 0.965 | 0.329 | 0.04 |
Initial FI | −0.403 | 0.01 | ||
Change in CCOi | −0.322 | 0.02 | ||
ΔVFI | Baseline MCA-PI | 0.917 | 0.168 | 0.04 |
Initial VFI | −0.84 | < 0.001 | ||
Change in CCOi | −0.307 | 0.04 |