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Indian Journal of Hematology and Blood Transfusion

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02.05.2023 | SHORT COMMUNICATION

CG02N Analyzer Accurately Measures Fibrinogen Level in Whole Blood in the Presence of Low- or High-Dose Heparin

verfasst von: Yoshihiko Nakamura, Junichi Maruyama, Takehiro Umemura, Kota Hoshino, Yuhei Irie, Shinichi Morimoto, Yoshito Izutani, Hiroyasu Ishikura

Erschienen in: Indian Journal of Hematology and Blood Transfusion | Ausgabe 1/2024

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Abstract

Rapid fibrinogen (Fbg) evaluation is important in patients with massive bleeding during severe trauma and those undergoing major surgery. However, there are only a few studies on the point-of-care Fbg analyzer. In this study, we aimed to investigate the accuracy of Fbg level measured using CG02N, with whole blood contained in lithium-heparinized syringes with two different concentrations of heparin. Blood samples were collected in lithium-heparinized tubes, namely PREZA-PAK®II (low-dose heparin group [LG], 7 IU/mL) and Pro-Vent® Plus (high-dose heparin group [HG], 70.5 IU/mL). The Fbg levels in LG and HG were compared with those of citrated plasma Fbg (standard-Fbg). Strong correlations with respect to the Fbg level were observed between standard-Fbg and LG or HG (r = 0.968, p < 0.0001; r = 0.970, p < 0.0001, respectively). We demonstrated that the Fbg level in whole-blood samples was accurately assessed by CG02N and not affected by low- or high-dose heparin.

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Titel: CG02N Analyzer Accurately Measures Fibrinogen Level in Whole Blood in the Presence of Low- or High-Dose Heparin
verfasst von: Yoshihiko Nakamura
Junichi Maruyama
Takehiro Umemura
Kota Hoshino
Yuhei Irie
Shinichi Morimoto
Yoshito Izutani
Hiroyasu Ishikura
Publikationsdatum: 02.05.2023
Verlag: Springer India
Erschienen in: Indian Journal of Hematology and Blood Transfusion / Ausgabe 1/2024
Print ISSN: 0971-4502
Elektronische ISSN: 0974-0449
DOI: https://doi.org/10.1007/s12288-023-01659-w

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CG02N Analyzer Accurately Measures Fibrinogen Level in Whole Blood in the Presence of Low- or High-Dose Heparin

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