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International Journal of Clinical Oncology

Erschienen in:

15.06.2018 | Original Article

Changes in programmed death ligand 1 expression in non-small cell lung cancer patients who received anticancer treatments

verfasst von: Shota Omori, Hirotsugu Kenmotsu, Masato Abe, Reiko Watanabe, Takashi Sugino, Haruki Kobayashi, Kazuhisa Nakashima, Kazushige Wakuda, Akira Ono, Tetsuhiko Taira, Tateaki Naito, Haruyasu Murakami, Yasuhisa Ohde, Masahiro Endo, Yasuto Akiyama, Takashi Nakajima, Toshiaki Takahashi

Erschienen in: International Journal of Clinical Oncology | Ausgabe 6/2018

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Abstract

Background

The expression of programmed death ligand 1 (PD-L1) is considered a predictive biomarker of anti-programmed death 1 (PD-1)/PD-L1 cancer therapies. However, changes in PD-L1 expression of tumor cells during clinical courses have not been fully evaluated. We evaluated changes in PD-L1 expression for non-small cell lung cancer (NSCLC) patients who received anticancer treatments during clinical courses.

Methods

In 76 NSCLC patients, PD-L1 expression was evaluated before and after anticancer treatment by immunohistochemical (IHC) analysis using an anti-PD-L1 antibody. We defined two cut-off points of PD-L1 expression (1 and 50%) and three corresponding IHC groups (A: 0%, B: 1–49%, and C: ≥50%). IHC group B and C were considered to be positive expression, and we defined the difference of IHC group between pre- and post-treatment as ‘major change’ in PD-L1 expression.

Results

Before anticancer treatment, PD-L1 expression was observed in 38/76 (50%) patients, and was significantly less common in patients harboring mutations in the epidermal growth factor receptor gene (EGFR) than in those without (P = 0.039). After anticancer treatment, PD-L1 expression was observed in 36/76 (47%) patients. Major increases in PD-L1 expression were seen in 11 (14%), and major decreases in 18 (24%) patients. Among 13 patients harboring EGFR mutations treated with EGFR tyrosine-kinase inhibitor (EGFR-TKI), five (38%) showed major increases.

Conclusion

Major changes of PD-L1 expression in tumor cells were observed in 38% of NSCLC patients who received anticancer treatments. And, treatments with EGFR-TKI may increase PD-L1 expression in NSCLC patients harboring EGFR mutations.

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Titel: Changes in programmed death ligand 1 expression in non-small cell lung cancer patients who received anticancer treatments
verfasst von: Shota Omori
Hirotsugu Kenmotsu
Masato Abe
Reiko Watanabe
Takashi Sugino
Haruki Kobayashi
Kazuhisa Nakashima
Kazushige Wakuda
Akira Ono
Tetsuhiko Taira
Tateaki Naito
Haruyasu Murakami
Yasuhisa Ohde
Masahiro Endo
Yasuto Akiyama
Takashi Nakajima
Toshiaki Takahashi
Publikationsdatum: 15.06.2018
Verlag: Springer Japan
Erschienen in: International Journal of Clinical Oncology / Ausgabe 6/2018
Print ISSN: 1341-9625
Elektronische ISSN: 1437-7772
DOI: https://doi.org/10.1007/s10147-018-1305-4

Springer Medizin

Changes in programmed death ligand 1 expression in non-small cell lung cancer patients who received anticancer treatments