nach oben

Erschienen in:

01.04.2015 | Experimental Research - Pediatrics

Changes of fractional anisotropy (FA) and apparent diffusion coefficient (ADC) in the model of experimental acute hydrocephalus in rabbits

verfasst von: Maxim A. Shevtsov, Konstantin A. Senkevich, Alexander V. Kim, Kseniia A. Gerasimova, Tatyana N. Trofimova, Galina V. Kataeva, Sviatoslav V. Medvedev, Olga I. Smirnova, Zhanna I. Savintseva, Marina G. Martynova, Olga A. Bystrova, Emil Pitkin, Galina Y. Yukina, William A. Khachatryan

Erschienen in: Acta Neurochirurgica | Ausgabe 4/2015

Einloggen, um Zugang zu erhalten

Abstract

Background

To study the integrity of white matter, we investigated the correlation between the changes in neuroradiological and morphological parameters in an animal model of acute obstructive hydrocephalus.

Methods

Hydrocephalus was induced in New Zealand rabbits (n = 10) by stereotactic injection of kaolin into the lateral ventricles. Control animals received saline in place of kaolin (n = 10). The progression of hydrocephalus was assessed using magnetic resonance imaging. Regional fractional anisotropy (FA) and the apparent diffusion coefficient (ADC) were measured in several white matter regions before and after the infusion of kaolin. Morphology of myelinated nerve fibers as well as of the blood–brain barrier were studied with the help of transmission electron microscopy (TEM) and light microscopy.

Results

Compared with control animals, kaolin injection into the ventricles resulted in a dramatic increase in ventricular volume with compression of basal cisterns, brain shift and periventricular edema (as observed on magnetic resonance imaging [MRI]). The values of ADC in the periventricular and periaqueductal areas significantly increased in the experimental group (P < 0.05). FA decreased by a factor of 2 in the zones of periventricular, periaqueductal white matter and corpus collosum. Histological analysis demonstrated the impairment of the white matter and necrobiotic changes in the cortex. Microsctructural alterations of the myelin fibers were further proved with the help of TEM. Blood–brain barrier ultrastructure assessment showed the loss of its integrity.

Conclusions

The study demonstrated the correlation of the neuroradiological parameters with morphological changes. The abnormality of the FA and ADC parameters in the obstructive hydrocephalus represents a significant implication for the diagnostics and management of hydrocephalus in patients.

Bloch O, Auguste KI, Manley GT, Verkman AS (2006) Accelerated progression of kaolin-induced hydrocephalus in aquaporin-4-deficient mice. J Cereb Blood Flow Metab 26:1527–1537CrossRefPubMed

Braun KP, de Graaf RA, Vandertop WP, Gooskens RH, Tulleken KA, Nicolay K (1998) In vivo 1H MR spectroscopic imaging and diffusion weighted MRI in experimental hydrocephalus. Magn Reson Med 40:832–839CrossRefPubMed

Braun KP, Dijkhuizen RM, de Graaf RA, Nicolay K, Vandertop WP, Gooskens RH, Tulleken KA (1997) Cerebral ischemia and white matter edema in experimental hydrocephalus: a combined in vivo MRI and MRS study. Brain Res 757:295–298CrossRefPubMed

Braun KP, van Eijsden P, Vandertop WP, de Graaf RA, Gooskens RH, Tulleken KA, Nikolay K (1999) Cerebral metabolism in experimental hydrocephalus: an in vivo 1H and 31P magnetic resonance spectroscopy study. J Neurosurg 91:660–668CrossRefPubMed

Braun KP, Vandertop WP, Gooskens RH, Tulleken KA, Nicolay K (2000) NMR spectroscopic evaluation of cerebral metabolism in hydrocephalus: a review. Neurol Res 22:51–64PubMed

Castejón OJ (2009) Blood–brain barrier ultrastructural alterations in human congenital hydrocephalus and Arnold-Chiari malformation. Folia Neuropathol 47:11–19PubMed

Cauley KA, Cataltepe O (2014) Axial diffusivity of the corona radiata correlated with ventricular size in adult hydrocephalus. AJR Am J Roentgenol 203:170–179CrossRefPubMed

Cherian S, Whitelaw A, Thoresen M, Love S (2004) The pathogenesis of neonatal post-hemorrhagic hydrocephalus. Brain Pathol 14:305–311CrossRefPubMed

Chua CO, Chahboune H, Braun A, Dummula K, Chua CE, Yu J, Ungvari Z, Sherbany AA, Hyder F, Ballabh P (2009) Consequences of intraventricular hemorrhage in a rabbit pup model. Stroke 40:3369–3377CrossRefPubMedCentralPubMed

10.

Collins P (1979) Experimental obstructive hydrocephalus in the rat: a scanning electron microscopic study. Neuropathol Appl Neurobiol 5:457–468CrossRefPubMed

11.

De Lahunta A (1983) Veterinary neuroanatomy and clinical neurology, 2nd edn. WB Saunders, Philadelphia

12.

Del Bigio MR, Kanfer JN, Zhang YW (1997) Myelination delay in the cerebral white matter of immature rats with kaolin-induced hydrocephalus is reversible. J Neuropathol Exp Neurol 56:1053–1066CrossRefPubMed

13.

Del Bigio MR, Khan OH, da Silva LL, Juliet PA (2012) Cerebral white matter oxidation and nitrosylation in young rodents with kaolin-induced hydrocephalus. J Neuropathol Exp Neurol 71:274–288CrossRefPubMed

14.

Del Bigio MR, Slobodian I, Schellenberg AE, Buist RJ, Kemp-Buors TL (2011) Magnetic resonance imaging indicators of blood–brain barrier and brain water changes in young rats with kaolin-induced hydrocephalus. Fluids Barriers CNS 8:22CrossRefPubMedCentralPubMed

15.

Edvinsson L, West KA (1971) The time-course of intracranial hypertension as recorded in conscious rabbits after treatment with different amounts of intracisternally injected kaolin. Acta Neurol Scand 47:439–450CrossRefPubMed

16.

Eskandari R, Abdullah O, Mason C, Lloyd KE, Oeschle AN, McAllister JP 2nd (2014) Differential vulnerability of white matter structures to experimental infantile hydrocephalus detected by diffusion tensor imaging. Childs Nerv Syst 30:1651–1661CrossRefPubMed

17.

Fishman RA (1992) Cerebrospinal fluid in diseases of the nervous system. W.B. Saunders, Philadelphia

18.

Haworth CS, Sobieski MW, Scheld WM, Park TS (1990) Staphylococcus aureus ventriculitis treated with single-dose intraventricular vancomycin or daptomycin (LY146032): bacterial and antibiotic kinetics in hydrocephalic rabbits. Antimicrob Agents Chemother 34:245–251CrossRefPubMedCentralPubMed

19.

Hoza D, Vlasák A, Hořínek D, Sameš M, Alfieri A (2014) DTI-MRI biomarkers in the search for normal pressure hydrocephalus aetiology: a review. Neurosurg Rev. doi:10.1007/s10143-014-0584-0

20.

Ishii K, Hashimoto M, Hayashida K, Hashikawa K, Chang CC, Nakagawara J, Nakayama T, Mori S, Sakakibara R (2011) A multicenter brain perfusion SPECT study evaluating idiopathic normal-pressure hydrocephalus on neurological improvement. Dement Geriatr Cogn Disord 32:1–10CrossRefPubMed

21.

Ivkovic M, Liu B, Ahmed F, Moore D, Huang C, Raj A, Kovanlikaya I, Heier L, Relkin N (2013) Differential diagnosis of normal pressure hydrocephalus by MRI mean diffusivity histogram analysis. AJNR Am J Neuroradiol 34:1168–1174CrossRefPubMed

22.

Johnson MJ, Ayzman I, Wood AS, Tkach JA, Klauschie J, Skarupa DJ, McAllister JP, Luciano MG (1999) Development and characterization of an adult model of obstructive hydrocephalus. J Neurosci Methods 91:55–65CrossRefPubMed

23.

Johnston MG, Del Bigio MR, Drake JM, Armstrong D, Di Curzio DL, Bertrand J (2013) Pre- and post-shunting observations in adult sheep with kaolin-induced hydrocephalus. Fluids Barriers CNS 10:24CrossRefPubMedCentralPubMed

24.

Klarica M, Oresković D, Bozić B, Vukić M, Butković V, Bulat M (2009) New experimental model of acute aqueductal blockage in cats: effects on cerebrospinal fluid pressure and the size of brain ventricles. Neuroscience 158:1397–1405CrossRefPubMed

25.

Kobayashi S, Kato K, Rodríguez Guerrero A, Baba H, Yoshizawa H (2012) Experimental syringohydromyelia induced by adhesive arachnoiditis in the rabbit: changes in the blood-spinal cord barrier, neuroinflammatory foci, and syrinx formation. J Neurotrauma 29:1803–1816CrossRefPubMed

26.

Kondziella D, Eyjolfsson EM, Saether O, Sonnewald U, Risa O (2009) Gray matter metabolism in acute and chronic hydrocephalus. Neuroscience 159:570–577CrossRefPubMed

27.

Kondziella D, Sonnewald U, Tullberg M, Wikkelso C (2008) Brain metabolism in adult chronic hydrocephalus. J Neurochem 106:1515–1524CrossRefPubMed

28.

Kulkarni AV, Riva-Cambrin J, Browd SR, Drake JM, Holubkov R, Kestle JR, Limbrick DD, Rozzelle CJ, Simon TD, Tamber MS, Wellons JC 3rd, Whitehead WE, Hydrocephalus Clinical Research Network (2014) Endoscopic third ventriculostomy and choroid plexus cauterization in infants with hydrocephalus: a retrospective Hydrocephalus Clinical Research Network study. J Neurosurg Pediatr 14:224–229CrossRefPubMed

29.

Kulkarni AV, Riva-Cambrin J, Butler J, Browd SR, Drake JM, Holubkov R, Kestle JR, Limbrick DD, Simon TD, Tamber MS, Wellons JC 3rd, Whitehead WE, Hydrocephalus Clinical Research Network (2013) Outcomes of CSF shunting in children: comparison of Hydrocephalus Clinical Research Network cohort with historical controls: clinical article. J Neurosurg Pediatr 12:334–338CrossRefPubMed

30.

Kurt G, Cemil B, Borcek AO, Borcek P, Akyurek N, Sepici A, Ceviker N (2010) Infliximab administration reduces neuronal apoptosis on the optic pathways in a rabbit hydrocephalus model: a preliminary report. Br J Neurosurg 24:275–279CrossRefPubMed

31.

Leliefeld PH, Gooskens RH, Braun KP, Ramos LM, Uiterwaal CS, Regli LP, Tulleken CA, Kappelle LJ, Hanlo PW (2009) Longitudinal diffusion-weighted imaging in infants with hydrocephalus: decrease in tissue water diffusion after cerebrospinal fluid diversion. J Neurosurg Pediatr 4:56–63CrossRefPubMed

32.

Leliefeld PH, Gooskens RH, Vincken KL, Ramos LM, van der Grond J, Tulleken CA, Kappelle LJ, Hanlo PW (2008) Magnetic resonance imaging for quantitative flow measurement in infants with hydrocephalus: a prospective study. J Neurosurg Pediatr 2:163–170CrossRefPubMed

33.

Lu Y, Qian L, Zhang Q, Chen B, Gui L, Huang D, Cheng G, Chen L (2013) Palmitateinduces apoptosis in mouse aortic endothelial cells and endothelial dysfunction in mice fed high-calorie and high-cholesterol diets. Life Sci 92:1165–1173CrossRefPubMed

34.

Massicotte EM, Buist R, Del Bigio MR (2000) Altered diffusion and perfusion in hydrocephalic rat brain: a magnetic resonance imaging analysis. J Neurosurg 92:442–447CrossRefPubMed

35.

Reddy GK, Bollam P, Caldito G (2014) Long-term outcomes of ventriculoperitoneal shunt surgery in patients with hydrocephalus. World Neurosurg 81:404–410CrossRefPubMed

36.

Scheel M, Diekhoff T, Sprung C, Hoffmann KT (2012) Diffusion tensor imaging in hydrocephalus—findings before and after shunt surgery. Acta Neurochir (Wien) 154:1699–1706CrossRef

37.

Slobodian I, Krassioukov-Enns D, Del Bigio MR (2007) Protein and synthetic polymer injection for induction of obstructive hydrocephalus in rats. Cerebrospinal Fluid Res 4:9CrossRefPubMedCentralPubMed

38.

Tarnaris A, Toma AK, Pullen E, Chapman MD, Petzold A, Cipolotti L, Kitchen ND, Keir G, Lemieux L, Watkins LD (2011) Cognitive, biochemical, and imaging profile of patients suffering from idiopathic normal pressure hydrocephalus. Alzheimers Dement 7:501–508CrossRefPubMed

39.

Torvik A, Stenwig AE, Finseth I (1981) The pathology of experimental obstructive hydrocephalus. A scanning electron microscopic study. Acta Neuropathol 54:143–147CrossRefPubMed

40.

Tully HM, Dobyns WB (2014) Infantile hydrocephalus: a review of epidemiology, classification and causes. Eur J Med Genet 57:359–368CrossRefPubMed

41.

Ueno M, Tomita S, Nakagawa T, Ueki M, Iwanaga Y, Ono J, Onodera M, Huang CL, Kanenishi K, Shimada A, Maekawa N, Sakamoto H (2006) Effects of aging and HIF-1alpha deficiency on permeability of hippocampal vessels. Microsc Res Tech 69:29–35CrossRefPubMed

42.

Vullo T, Manzo R, Gomez DG, Deck MD, Cahill PT (1998) A canine model of acute hydrocephalus with MR correlation. AJNR Am J Neuroradiol 19:1123–1125PubMed

43.

Weller RO, Mitchell J, Griffin RL, Gardner MJ (1978) The effects of hydrocephalus upon the developing brain. Histological and quantitative studies of the ependyma and subependyma in hydrocephalic rats. J Neurol Sci 36:383–402CrossRefPubMed

44.

Wen YD, Wang H, Kho SH, Rinkiko S, Sheng X, Shen HM, Zhu YZ (2013) Hydrogen sulfide protects HUVECs against hydrogen peroxide induced mitochondrial dysfunction and oxidative stress. PLoS One 8:e53147CrossRefPubMedCentralPubMed

45.

Yuan W, McAllister JP 2nd, Lindquist DM, Gill N, Holland SK, Henkel D, Rajagopal A, Mangano FT (2012) Diffusion tensor imaging of white matter injury in a rat model of infantile hydrocephalus. Childs Nerv Syst 28:47–54CrossRefPubMed

46.

Ziegelitz D, Starck G, Kristiansen D, Jakobsson M, Hultenmo M, Mikkelsen IK, Hellström P, Tullberg M, Wikkelsø C (2014) Cerebral perfusion measured by dynamic susceptibility contrast MRI is reduced in patients with idiopathic normal pressure hydrocephalus. J Magn Reson Imaging 39:1533–1542CrossRefPubMed

Titel: Changes of fractional anisotropy (FA) and apparent diffusion coefficient (ADC) in the model of experimental acute hydrocephalus in rabbits
verfasst von: Maxim A. Shevtsov
Konstantin A. Senkevich
Alexander V. Kim
Kseniia A. Gerasimova
Tatyana N. Trofimova
Galina V. Kataeva
Sviatoslav V. Medvedev
Olga I. Smirnova
Zhanna I. Savintseva
Marina G. Martynova
Olga A. Bystrova
Emil Pitkin
Galina Y. Yukina
William A. Khachatryan
Publikationsdatum: 01.04.2015
Verlag: Springer Vienna
Erschienen in: Acta Neurochirurgica / Ausgabe 4/2015
Print ISSN: 0001-6268
Elektronische ISSN: 0942-0940
DOI: https://doi.org/10.1007/s00701-014-2339-7

Leitlinien kompakt für die Neurologie

Mit medbee Pocketcards sicher entscheiden.

^{Seit 2022 gehört die medbee GmbH zum Springer Medizin Verlag}

Kostenlos registrieren

Neu im Fachgebiet Neurologie

Sind Frauen die fähigeren Ärzte?

30.04.2024 Gendermedizin Nachrichten

Patienten, die von Ärztinnen behandelt werden, dürfen offenbar auf bessere Therapieergebnisse hoffen als Patienten von Ärzten. Besonders gilt das offenbar für weibliche Kranke, wie eine Studie zeigt.

Akuter Schwindel: Wann lohnt sich eine MRT?

28.04.2024 Schwindel Nachrichten

Akuter Schwindel stellt oft eine diagnostische Herausforderung dar. Wie nützlich dabei eine MRT ist, hat eine Studie aus Finnland untersucht. Immerhin einer von sechs Patienten wurde mit akutem ischämischem Schlaganfall diagnostiziert.

Niedriger diastolischer Blutdruck erhöht Risiko für schwere kardiovaskuläre Komplikationen

25.04.2024 Hypotonie Nachrichten

Wenn unter einer medikamentösen Hochdrucktherapie der diastolische Blutdruck in den Keller geht, steigt das Risiko für schwere kardiovaskuläre Ereignisse: Darauf deutet eine Sekundäranalyse der SPRINT-Studie hin.

Frühe Alzheimertherapie lohnt sich

25.04.2024 AAN-Jahrestagung 2024 Nachrichten

Ist die Tau-Last noch gering, scheint der Vorteil von Lecanemab besonders groß zu sein. Und beginnen Erkrankte verzögert mit der Behandlung, erreichen sie nicht mehr die kognitive Leistung wie bei einem früheren Start. Darauf deuten neue Analysen der Phase-3-Studie Clarity AD.

Update Neurologie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.

Newsletter bestellen

Springer Medizin

Abstract

Background

Methods

Results

Conclusions

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

Weitere Artikel der Ausgabe 4/2015

Dosimetric comparison of different treatment modalities for stereotactic radiosurgery of meningioma

Multiple meningiomas in patients with Turner syndrome

Burr hole is not burr hole

Results of nerve reconstructions in treatment of obstetrical brachial plexus injuries

Gamma Knife, CyberKnife or micro-multileaf collimator LINAC for intracranial radiosurgery?