Introduction
Material and Methods
Study Population
Standard Operation
Diagnosis of Pouchitis
Statistical Analysis
Results
Case | Gender | Age (years) | Disease duration (months) | Extent of colitis | Disease severity | Disease type | Total dosage of prednisolone (mg) | Dosage of prednisolone just before surgery (mg/month) | IM just before surgery | Postoperative complications excluding PC | Steroid withdrawal syndrome | Days between ileostomy closure and first PC onset (days) | Modified PDAI | Classification categories for pouchitis subtypes |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | Male | 40 | 18 | Total | Severe | Relapse-remitting | 8,000 | 600 | N | Pelvic abscess Perianal fistula | Y | 6 | 8 | chronic |
2 | Male | 53 | 28 | Total | Moderate | Relapse-remitting | 12,000 | 600 | N | Perianal fistula | Y | 7 | 8 | chronic |
3 | Male | 32 | 39 | Total | Moderate | Chronic continuous | 20,000 | 900 | N | None | N | 8 | 9 | chronic |
4 | Female | 19 | 8 | Total | Severe | Acute fulminanting | 3,400 | 900 | CYS | None | N | 9 | 8 | acute |
5 | Female | 23 | 79 | Left-sided | Moderate | Chronic continuous | 43,000 | 750 | CYS | Partial vein thrombi | Y | 13 | 10 | chronic |
6 | Male | 41 | 60 | Total | Severe | Relapse-remitting | 34,000 | 620 | N | Small bowel obstruction | N | 20 | 5 | chronic |
7 | Male | 58 | 75 | Total | Moderate | Relapse-remitting | 9,000 | 900 | TAC | Small bowel obstruction | N | 21 | 11 | chronic |
8 | Male | 37 | 21 | Left-sided | Severe | Chronic continuous | 8,000 | 600 | N | Pelvic abscess | N | 28 | 11 | acute |
Factors | Non-EEOP | EEOP |
P
|
---|---|---|---|
n = 54 |
n = 8 | ||
Gender (male/female) | 30/24 | 6/2 | 0.45 |
Age at initial surgery (years) | 32 ± 15 | 38 ± 13 | 0.24 |
Disease duration (years) | 7.5 ± 6.9 | 5.5 ± 6.2 | 0.28 |
Type of disease (acute fulminating/relapse–remitting/chronic continuous) | 5/38/11 | 1/4/3 | 0.49 |
Extent of colitis (left-sided colitis/total colitis) | 7/47 | 2/6 | 0.33 |
Severity of colitis (severe/moderate/mild) | 11/32/11 | 2/5/1 | 0.86 |
Extraintestinal manifestation (Y/N) | 2/52 | 0/8 | 1.00 |
Total dosage of steroid before surgery (g) | 19.1 ± 19.6 | 17.6 ± 13.8 | 0.90 |
Dosage of steroid per month just before surgery (mg) | 518 ± 450 | 734 ± 146 | 0.03 |
Immunomodulator (Y/N) | 22/32 | 4/4 | 0.71 |
Emergency or urgent operation at first operation (Y/N) | 11/43 | 1/7 | 0.59 |
Operation stages (one stage/two stage/three stage) | 3/37/14 | 0/7/1 | 0.52 |
Postoperative pelvic abscess (Y/N) | 8/46 | 2/6 | 0.60 |
Factors | Odds ratio | 95%CI |
P
|
---|---|---|---|
Gender (male) | 1.35 | 0.85–2.15 | 0.45 |
Age at initial surgery (>32 years) | 4.04 | 0.75–21.89 | 0.13 |
Disease duration (<6 years) | 1.79 | 0.39–8.27 | 0.45 |
Type of disease (chronic continuous) | 2.35 | 0.48–11.35 | 0.36 |
Type of disease (relapse–remitting) | 0.42 | 0.09–1.89 | 0.42 |
Type of disease (acute fulminating) | 1.40 | 0.14–13.8 | 0.58 |
Extent of colitis (left-sided colitis) | 2.24 | 0.37–13.36 | 0.33 |
Severity of colitis (severe) | 1.30 | 0.23–7.36 | 0.67 |
Total dosage of steroid before surgery (>8 g) | 1.08 | 0.24–4.76 | 1.00 |
Dosage of steroid per month just before surgery (>600 mg) | 4.12 | 0.88–19.82 | 0.10 |
Use of immunomodulator (Y) | 1.45 | 0.33–6.44 | 0.71 |
Emergency or urgent operation at first operation (Y) | 0.56 | 0.06–5.00 | 1.00 |
Operation stages (two stage) | 3.22 | 0.37–28.24 | 0.42 |
Operation stages (three stage) | 0.41 | 0.05–3.57 | 0.67 |
Postoperative pelvic abscess (Y) | 1.22 | 0.13–11.27 | 1.00 |
Odds ratio | 95%CI |
P
| |
---|---|---|---|
Age at initial surgery (>32 years) | 3.60 | 0.66–25.55 | 0.14 |
Type of disease (chronic continuous) | 4.69 | 0.63–44.83 | 0.13 |
Extent of colitis (left-sided colitis) | 1.58 | 0.08–6.05 | 0.67 |
Dosage of steroid per month just before surgery (>600 mg) | 6.26 | 1.09–52.78 | 0.039 |
Factors | Non-EEOP (n = 54) | EEOP |
P
|
---|---|---|---|
Modified PDAI | 6.1 ± 1.5 | 8.8 ± 2.0 | 0.0009 |
Clinical criteria | 2.9 ± 0.8 | 4.0 ± 0.9 | 0.0031 |
Endoscopic criteria | 3.2 ± 1.0 | 4.8 ± 1.4 | 0.0035 |
Classification categories for pouchitis subtypes (acute/chronic) | 42/12 | 2/6 | 0.0056 |