Erschienen in:
01.10.2006 | Editorial Review
Chemotherapy and Regional Therapy of Hepatic Colorectal Metastases: Expert Consensus Statement by Bartlett et al.
verfasst von:
Ravi S. Chari, MD, W. Scott Helton, MD, Robert D. Marsh, MD
Erschienen in:
Annals of Surgical Oncology
|
Ausgabe 10/2006
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Excerpt
Several new agents for the treatment of metastatic colorectal carcinoma (CRC) have been developed over the past few years. Various combinations of these agents, with or without liver-directed therapies, have been shown to improve the outcomes of patients with metastatic colorectal liver metastases (CRCLM). In this edition of the journal, as part of an AHPBA-SSAT-SSO co-sponsored consensus panel meeting, Barlett
et al. insightfully reviewed the current data pertaining to systemic and regional chemotherapy of CRCLM. The consensus panel report reviewed these therapies from three standpoints: systemic chemotherapy for unresectable patients, adjuvant therapy for resected CRCLM, and intra-arterial therapies for unresectable CRCLM. In addition, the authors discussed the challenge of optimizing any chemotherapeutic approach given the recent, almost simultaneous, regulatory approval of a number of novel biologic agents and the potential of some, if not all, of these to cause liver damage, which in turn may adversely affect a patient’s ability to survive a potentially curative liver resection.
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