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Erschienen in: Current Oncology Reports 11/2023

13.09.2023

Chemotherapy-Induced Peripheral Neuropathy: Diagnosis, Agents, General Clinical Presentation, and Treatments

verfasst von: Diana Molinares, Sara Kurtevski, Yingrong Zhu

Erschienen in: Current Oncology Reports | Ausgabe 11/2023

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Abstract

Purpose of Review

This review aims to discuss pathophysiology, diagnosis, clinical presentation, and treatment of chemotherapy-induced peripheral neuropathy. Agent-specific presentation and pathophysiology is also being discussed.

Recent Findings

As new systemic oncological treatments continue to be developed, the number of cancer survivors continues to grow. Survivors are living longer with the long-term side effects of oncological treatments. We reviewed the pathophysiology of agent-specific chemotherapy-induced peripheral neuropathy and the updates in its treatment and preventative tools.

Summary

Chemotherapy-induced peripheral neuropathy is a debilitating long-term side effect that often impairs cancer survivors’ function and quality of life. The increasing life expectancy of cancer survivors has resulted in increased prevalence of this condition. Understanding its intricacies can provide physicians with better treatment tools and research opportunities to develop or identify new therapeutic agents.
Literatur
1.
Zurück zum Zitat • Zhang S. Chemotherapy-induced peripheral neuropathy and rehabilitation: a review. Semin Oncol. 2021;48(3):193–207. https://doi.org/10.1053/j.seminoncol.2021.09.004. This article reviews the impact of CIPN in survivors’ quality of life and the role of cancer rehabilitation medicine. The authors reviewed the treatment options and rehabilitation interventions for patients with CIPN. • Zhang S. Chemotherapy-induced peripheral neuropathy and rehabilitation: a review. Semin Oncol. 2021;48(3):193–207. https://​doi.​org/​10.​1053/​j.​seminoncol.​2021.​09.​004. This article reviews the impact of CIPN in survivors’ quality of life and the role of cancer rehabilitation medicine. The authors reviewed the treatment options and rehabilitation interventions for patients with CIPN.
3.
Zurück zum Zitat • Burgess J, Ferdousi M, Gosal D, Boon C, Matsumoto K, Marshall A, Mak T, Marshall A, Frank B, Malik RA, Alam U. Chemotherapy-induced peripheral neuropathy: epidemiology, pathomechanisms and treatment. Oncol Ther. 2021;9(2):385–450. https://doi.org/10.1007/s40487-021-00168-y. This article highlights the epidemiology of CIPN as well as preventative treatments. Authors highlight the importance of identifying at risk patients and further investigate into preventive measures as well as new symptomatic treatments.CrossRefPubMedPubMedCentral • Burgess J, Ferdousi M, Gosal D, Boon C, Matsumoto K, Marshall A, Mak T, Marshall A, Frank B, Malik RA, Alam U. Chemotherapy-induced peripheral neuropathy: epidemiology, pathomechanisms and treatment. Oncol Ther. 2021;9(2):385–450. https://​doi.​org/​10.​1007/​s40487-021-00168-y. This article highlights the epidemiology of CIPN as well as preventative treatments. Authors highlight the importance of identifying at risk patients and further investigate into preventive measures as well as new symptomatic treatments.CrossRefPubMedPubMedCentral
4.
Zurück zum Zitat Kerckhove N, Collin A, Condé S, Chaleteix C, Pezet D, Balayssac D. Long-term effects, pathophysiological mechanisms, and risk factors of chemotherapy-induced peripheral neuropathies: a comprehensive literature review. Front Pharmacol. 2017;8 https://doi.org/10.3389/fphar.2017.00086. Kerckhove N, Collin A, Condé S, Chaleteix C, Pezet D, Balayssac D. Long-term effects, pathophysiological mechanisms, and risk factors of chemotherapy-induced peripheral neuropathies: a comprehensive literature review. Front Pharmacol. 2017;8 https://​doi.​org/​10.​3389/​fphar.​2017.​00086.
5.
Zurück zum Zitat • Tofthagen, C. S., Cheville, A. L., & Loprinzi, C. L. (2020). The physical consequences of chemotherapy-induced peripheral neuropathy. Curr Oncol Rep, 22(5). https://doi.org/10.1007/s11912-020-00903-0. This article reviews the effects of CIPN in survivors’ physical function and the long-term impact in their wellbeing. The authors discussed the evidence-based interventions currently available to treat this condition. • Tofthagen, C. S., Cheville, A. L., & Loprinzi, C. L. (2020). The physical consequences of chemotherapy-induced peripheral neuropathy. Curr Oncol Rep, 22(5). https://​doi.​org/​10.​1007/​s11912-020-00903-0. This article reviews the effects of CIPN in survivors’ physical function and the long-term impact in their wellbeing. The authors discussed the evidence-based interventions currently available to treat this condition.
10.
Zurück zum Zitat van Haren F, van den Heuvel S, Ligtenberg M, Vissers K, Steegers M. Diagnostic tools should be used for the diagnosis of chemotherapy induced peripheral neuropathy in breast cancer patients receiving taxanes. Cancer Rep. 2021;5(10) https://doi.org/10.1002/cnr2.1577. van Haren F, van den Heuvel S, Ligtenberg M, Vissers K, Steegers M. Diagnostic tools should be used for the diagnosis of chemotherapy induced peripheral neuropathy in breast cancer patients receiving taxanes. Cancer Rep. 2021;5(10) https://​doi.​org/​10.​1002/​cnr2.​1577.
18.
Zurück zum Zitat Smith T, Nicholson RA. Review of duloxetine in the management of diabetic peripheral neuropathic pain. Vasc Health Risk Manag. 2007;3(6):833–44.PubMedPubMedCentral Smith T, Nicholson RA. Review of duloxetine in the management of diabetic peripheral neuropathic pain. Vasc Health Risk Manag. 2007;3(6):833–44.PubMedPubMedCentral
21.
24.
Zurück zum Zitat Durand JP, Deplanque G, Montheil V, Gornet JM, Scotte F, Mir O, et al. Efficacy of venlafaxine for the prevention and relief of oxaliplatin-induced acute neurotoxicity: results of EFFOX, a randomized, double-blind, placebo-controlled phase III trial. Ann Oncol. 2012;23(1):200–5. https://doi.org/10.1093/annonc/mdr045.CrossRefPubMed Durand JP, Deplanque G, Montheil V, Gornet JM, Scotte F, Mir O, et al. Efficacy of venlafaxine for the prevention and relief of oxaliplatin-induced acute neurotoxicity: results of EFFOX, a randomized, double-blind, placebo-controlled phase III trial. Ann Oncol. 2012;23(1):200–5. https://​doi.​org/​10.​1093/​annonc/​mdr045.CrossRefPubMed
28.
Zurück zum Zitat Kautio AL, Haanpaa M, Leminen A, Kalso E, Kautiainen H, Saarto T. Amitriptyline in the prevention of chemotherapy-induced neuropathic symptoms. Anticancer Res. 2009;29(7):2601–6. Kautio AL, Haanpaa M, Leminen A, Kalso E, Kautiainen H, Saarto T. Amitriptyline in the prevention of chemotherapy-induced neuropathic symptoms. Anticancer Res. 2009;29(7):2601–6.
31.
Zurück zum Zitat Rao RD, Michalak JC, Sloan JA, Loprinzi CL, Soori GS, Nikcevich DA, et al. Efficacy of gabapentin in the management of chemotherapy-induced peripheral neuropathy: a phase 3 randomized, double-blind, placebo-controlled, crossover trial (N00C3). Cancer. 2007;110(9):2110–8. https://doi.org/10.1002/cncr.23008.CrossRefPubMed Rao RD, Michalak JC, Sloan JA, Loprinzi CL, Soori GS, Nikcevich DA, et al. Efficacy of gabapentin in the management of chemotherapy-induced peripheral neuropathy: a phase 3 randomized, double-blind, placebo-controlled, crossover trial (N00C3). Cancer. 2007;110(9):2110–8. https://​doi.​org/​10.​1002/​cncr.​23008.CrossRefPubMed
32.
Zurück zum Zitat Saif MW, Syrigos K, Kaley K, Isufi I. Role of pregabalin in treatment of oxaliplatin-induced sensory neuropathy. Anticancer Res. 2010;30(7):2927–33.PubMed Saif MW, Syrigos K, Kaley K, Isufi I. Role of pregabalin in treatment of oxaliplatin-induced sensory neuropathy. Anticancer Res. 2010;30(7):2927–33.PubMed
40.
Zurück zum Zitat Leal AD, Qin R, Atherton PJ, Haluska P, Behrens RJ, Tiber CH, et al. North Central Cancer Treatment Group/Alliance trial N08CA-the use of glutathione for prevention of paclitaxel/carboplatin-induced peripheral neuropathy: a phase 3 randomized, double-blind, placebo-controlled study. Cancer. 2014;120(12):1890–7. https://doi.org/10.1002/cncr.28654.CrossRefPubMed Leal AD, Qin R, Atherton PJ, Haluska P, Behrens RJ, Tiber CH, et al. North Central Cancer Treatment Group/Alliance trial N08CA-the use of glutathione for prevention of paclitaxel/carboplatin-induced peripheral neuropathy: a phase 3 randomized, double-blind, placebo-controlled study. Cancer. 2014;120(12):1890–7. https://​doi.​org/​10.​1002/​cncr.​28654.CrossRefPubMed
55.
Zurück zum Zitat Huang CC, Ho TJ, Ho HY, Chen PY, Tu CH, Huang YC, et al. Acupuncture relieved chemotherapy-induced peripheral neuropathy in patients with breast cancer: a pilot randomized sham-controlled trial. J Clin Med. 2021;10(16) https://doi.org/10.3390/jcm10163694. Huang CC, Ho TJ, Ho HY, Chen PY, Tu CH, Huang YC, et al. Acupuncture relieved chemotherapy-induced peripheral neuropathy in patients with breast cancer: a pilot randomized sham-controlled trial. J Clin Med. 2021;10(16) https://​doi.​org/​10.​3390/​jcm10163694.
Metadaten
Titel
Chemotherapy-Induced Peripheral Neuropathy: Diagnosis, Agents, General Clinical Presentation, and Treatments
verfasst von
Diana Molinares
Sara Kurtevski
Yingrong Zhu
Publikationsdatum
13.09.2023
Verlag
Springer US
Erschienen in
Current Oncology Reports / Ausgabe 11/2023
Print ISSN: 1523-3790
Elektronische ISSN: 1534-6269
DOI
https://doi.org/10.1007/s11912-023-01449-7

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