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Erschienen in: Current Atherosclerosis Reports 6/2011

01.12.2011 | Nutrition (William S. Harris, Section Editor)

Chocolate and Coronary Heart Disease: A Systematic Review

verfasst von: Owais Khawaja, J. Michael Gaziano, Luc Djoussé

Erschienen in: Current Atherosclerosis Reports | Ausgabe 6/2011

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Abstract

Coronary heart disease (CHD) is the leading cause of death in the United States. The high content of polyphenols and flavonoids present in cocoa has been reported to play an important protective role in the development of CHD. Although studies have demonstrated beneficial effects of chocolate on endothelial function, blood pressure, serum lipids, insulin resistance, and platelet function, it is unclear whether chocolate consumption influences the risk of CHD. This article reviews current evidence on the effects of cocoa/chocolate on clinical and subclinical CHD, CHD risk factors, and potential biologic mechanisms. It also discusses major limitations of currently available data and future directions in the field.
Literatur
2.
Zurück zum Zitat Xu J, Kochanek KD, Murphy S, Tejada-Vera B. Deaths: final data for 2007. Hyattsville, Md: National Center for Health Statistics; 2010. National Vital Statistics Reports, Vol 58, No. 19. Xu J, Kochanek KD, Murphy S, Tejada-Vera B. Deaths: final data for 2007. Hyattsville, Md: National Center for Health Statistics; 2010. National Vital Statistics Reports, Vol 58, No. 19.
3.
Zurück zum Zitat Hu FB, Willett WC. Optimal diets for prevention of coronary heart disease. JAMA. 2002;288:2569–78.PubMedCrossRef Hu FB, Willett WC. Optimal diets for prevention of coronary heart disease. JAMA. 2002;288:2569–78.PubMedCrossRef
4.
Zurück zum Zitat Tanasescu M, Leitzmann MF, Rimm EB, et al. Exercise type and intensity in relation to coronary heart disease in men. JAMA. 2002;288:1994–2000.PubMedCrossRef Tanasescu M, Leitzmann MF, Rimm EB, et al. Exercise type and intensity in relation to coronary heart disease in men. JAMA. 2002;288:1994–2000.PubMedCrossRef
6.
Zurück zum Zitat Stampfer MJ, Hu FB, Manson JE, Rimm EB, Willett WC. Primary prevention of coronary heart disease in women through diet and lifestyle. N Engl J Med. 2000;343:16–22.PubMedCrossRef Stampfer MJ, Hu FB, Manson JE, Rimm EB, Willett WC. Primary prevention of coronary heart disease in women through diet and lifestyle. N Engl J Med. 2000;343:16–22.PubMedCrossRef
7.
Zurück zum Zitat Kris-Etherton PM, Keen CL. Evidence that the antioxidant flavonoids in tea and cocoa are beneficial for cardiovascular health. Curr Opin Lipidol. 2002;13:41–9.PubMedCrossRef Kris-Etherton PM, Keen CL. Evidence that the antioxidant flavonoids in tea and cocoa are beneficial for cardiovascular health. Curr Opin Lipidol. 2002;13:41–9.PubMedCrossRef
8.
Zurück zum Zitat Visioli F, Borsani L, Galli C. Diet and prevention of coronary heart disease: the potential role of phytochemicals. Cardiovasc Res. 2000;47:419–25.PubMedCrossRef Visioli F, Borsani L, Galli C. Diet and prevention of coronary heart disease: the potential role of phytochemicals. Cardiovasc Res. 2000;47:419–25.PubMedCrossRef
10.
Zurück zum Zitat Patel J, D’Souza J. Can we now eat chocolate without feeling guilty? J Am Pharm Assoc. 2008;48:438–40.CrossRef Patel J, D’Souza J. Can we now eat chocolate without feeling guilty? J Am Pharm Assoc. 2008;48:438–40.CrossRef
11.
Zurück zum Zitat Lee KW, Kim YJ, Lee HJ, Lee CY. Cocoa has more phenolic phytochemicals and a higher antioxidant capacity than teas and red wine. J Agric Food Chem. 2003;51:7292–5.PubMedCrossRef Lee KW, Kim YJ, Lee HJ, Lee CY. Cocoa has more phenolic phytochemicals and a higher antioxidant capacity than teas and red wine. J Agric Food Chem. 2003;51:7292–5.PubMedCrossRef
12.
Zurück zum Zitat Lee KW, Kim YJ, Lee HJ, Lee CY. Cocoa has more phenolic phytochemicals and a higher antioxidant capacity than teas and red wine. J Agric Food Chem. 2003;51:7292–5.PubMedCrossRef Lee KW, Kim YJ, Lee HJ, Lee CY. Cocoa has more phenolic phytochemicals and a higher antioxidant capacity than teas and red wine. J Agric Food Chem. 2003;51:7292–5.PubMedCrossRef
13.
Zurück zum Zitat Gu L, House SE, Wu X, Ou B, Prior RL. Procyanidin and catechin contents and antioxidant capacity of cocoa and chocolate products. J Agric Food Chem. 2006;54:4057–61.PubMedCrossRef Gu L, House SE, Wu X, Ou B, Prior RL. Procyanidin and catechin contents and antioxidant capacity of cocoa and chocolate products. J Agric Food Chem. 2006;54:4057–61.PubMedCrossRef
14.
Zurück zum Zitat Steinberg FM, Bearden MM, Keen CL. Cocoa and chocolate flavonoids: implications for cardiovascular health. J Am Diet Assoc. 2003;103:215–23.PubMedCrossRef Steinberg FM, Bearden MM, Keen CL. Cocoa and chocolate flavonoids: implications for cardiovascular health. J Am Diet Assoc. 2003;103:215–23.PubMedCrossRef
15.
Zurück zum Zitat Schini-Kerth VB, Auger C, Kim JH, Etienne-Selloum N, Chataigneau T. Nutritional improvement of the endothelial control of vascular tone by polyphenols: role of NO and EDHF. Pflugers Arch. 2010;459:853–62.PubMedCrossRef Schini-Kerth VB, Auger C, Kim JH, Etienne-Selloum N, Chataigneau T. Nutritional improvement of the endothelial control of vascular tone by polyphenols: role of NO and EDHF. Pflugers Arch. 2010;459:853–62.PubMedCrossRef
16.
Zurück zum Zitat Fisher ND, Hughes M, Gerhard-Herman M, Hollenberg NK. Flavanol-rich cocoa induces nitric-oxide-dependent vasodilation in healthy humans. J Hypertens. 2003;21:2281–6.PubMedCrossRef Fisher ND, Hughes M, Gerhard-Herman M, Hollenberg NK. Flavanol-rich cocoa induces nitric-oxide-dependent vasodilation in healthy humans. J Hypertens. 2003;21:2281–6.PubMedCrossRef
17.
Zurück zum Zitat Karim M, McCormick K, Kappagoda CT. Effects of cocoa extracts on endothelium-dependent relaxation. J Nutr. 2000;130(8S Suppl):2105S–8S.PubMed Karim M, McCormick K, Kappagoda CT. Effects of cocoa extracts on endothelium-dependent relaxation. J Nutr. 2000;130(8S Suppl):2105S–8S.PubMed
18.
Zurück zum Zitat Grassi D, Desideri G, Necozione S, et al. Blood pressure is reduced and insulin sensitivity increased in glucose-intolerant, hypertensive subjects after 15 days of consuming high-polyphenol dark chocolate. J Nutr. 2008;138:1671–6.PubMed Grassi D, Desideri G, Necozione S, et al. Blood pressure is reduced and insulin sensitivity increased in glucose-intolerant, hypertensive subjects after 15 days of consuming high-polyphenol dark chocolate. J Nutr. 2008;138:1671–6.PubMed
19.
Zurück zum Zitat Ried K, Sullivan T, Fakler P, Frank OR, Stocks NP. Does chocolate reduce blood pressure? A meta-analysis BMC Medicine. 2010;8:39. Ried K, Sullivan T, Fakler P, Frank OR, Stocks NP. Does chocolate reduce blood pressure? A meta-analysis BMC Medicine. 2010;8:39.
20.
Zurück zum Zitat Jia L, Liu X, Bai YY, et al. Short-term effect of cocoa product consumption on lipid profile: a meta-analysis of randomized controlled trials. Am J Clin Nutr. 2010;92:218–25.PubMedCrossRef Jia L, Liu X, Bai YY, et al. Short-term effect of cocoa product consumption on lipid profile: a meta-analysis of randomized controlled trials. Am J Clin Nutr. 2010;92:218–25.PubMedCrossRef
21.
Zurück zum Zitat Mellor DD, Sathyapalan T, Kilpatrick ES, Beckett S, Atkin SL. High-cocoa polyphenol-rich chocolate improves HDL cholesterol in Type 2 diabetes patients. Diabet Med. 2010;27:1318–21.PubMedCrossRef Mellor DD, Sathyapalan T, Kilpatrick ES, Beckett S, Atkin SL. High-cocoa polyphenol-rich chocolate improves HDL cholesterol in Type 2 diabetes patients. Diabet Med. 2010;27:1318–21.PubMedCrossRef
22.
Zurück zum Zitat Davison K, Coates AM, Buckley JD, Howe PR. Effect of cocoa flavanols and exercise on cardiometabolic risk factors in overweight and obese subjects. Int J Obes. 2008;32:1289–96.CrossRef Davison K, Coates AM, Buckley JD, Howe PR. Effect of cocoa flavanols and exercise on cardiometabolic risk factors in overweight and obese subjects. Int J Obes. 2008;32:1289–96.CrossRef
23.
Zurück zum Zitat Pearson DA, Paglieroni TG, Rein D, et al. The effects of flavanol-rich cocoa and aspirin on ex vivo platelet function. Thromb Res. 2002;106:191–7.PubMedCrossRef Pearson DA, Paglieroni TG, Rein D, et al. The effects of flavanol-rich cocoa and aspirin on ex vivo platelet function. Thromb Res. 2002;106:191–7.PubMedCrossRef
24.
Zurück zum Zitat Innes AJ, Kennedy G, McLaren M, Bancroft AJ, Belch JJ. Dark chocolate inhibits platelet aggregation in healthy volunteers. Platelets. 2003;14:325–7.PubMedCrossRef Innes AJ, Kennedy G, McLaren M, Bancroft AJ, Belch JJ. Dark chocolate inhibits platelet aggregation in healthy volunteers. Platelets. 2003;14:325–7.PubMedCrossRef
25.
Zurück zum Zitat • Djoussé L, Hopkins PN, North KE, et al: Chocolate consumption is inversely associated with prevalent coronary heart disease: The National Heart, Lung, and Blood Institute Family Heart Study. Clin Nutr 2011, 30:182–187. This large cross-sectional analysis among 25- to 93-year-old study participants showed an inverse relation between chocolate consumption and prevalent coronary heart disease and a 49% increased prevalence odds of coronary disease among people consuming non-chocolate candy.PubMedCrossRef • Djoussé L, Hopkins PN, North KE, et al: Chocolate consumption is inversely associated with prevalent coronary heart disease: The National Heart, Lung, and Blood Institute Family Heart Study. Clin Nutr 2011, 30:182–187. This large cross-sectional analysis among 25- to 93-year-old study participants showed an inverse relation between chocolate consumption and prevalent coronary heart disease and a 49% increased prevalence odds of coronary disease among people consuming non-chocolate candy.PubMedCrossRef
26.
Zurück zum Zitat •• Lewis JR, Prince RL, Zhu K, et al: Habitual Chocolate Intake and Vascular Disease: A Prospective Study of Clinical Outcomes in Older Women. Arch Intern Med 2010, 170:1857–1858. This prospective study demonstrated that frequent chocolate intake was associated with a lower risk of hospitalization for ischemic heart disease and heart failure or death in older women.PubMedCrossRef •• Lewis JR, Prince RL, Zhu K, et al: Habitual Chocolate Intake and Vascular Disease: A Prospective Study of Clinical Outcomes in Older Women. Arch Intern Med 2010, 170:1857–1858. This prospective study demonstrated that frequent chocolate intake was associated with a lower risk of hospitalization for ischemic heart disease and heart failure or death in older women.PubMedCrossRef
27.
Zurück zum Zitat Shiina Y, Funabashi N, Lee K, et al. Acute effect of oral flavonoid-rich dark chocolate intake on coronary circulation, as compared with non-flavonoid white chocolate, by transthoracic Doppler echocardiography in healthy adults. Int J Cardiol. 2009;131:424–9.PubMedCrossRef Shiina Y, Funabashi N, Lee K, et al. Acute effect of oral flavonoid-rich dark chocolate intake on coronary circulation, as compared with non-flavonoid white chocolate, by transthoracic Doppler echocardiography in healthy adults. Int J Cardiol. 2009;131:424–9.PubMedCrossRef
28.
Zurück zum Zitat •• Djoussé L, Hopkins PN, Arnett DK, et al: Chocolate consumption is inversely associated with calcified atherosclerotic plaque in the coronary arteries: The NHLBI Family Heart Study. Clin Nutr 2011, 30:38–43. This study showed for the first time an inverse association between chocolate consumption and subclinical atherosclerosis (coronary artery calcium).PubMedCrossRef •• Djoussé L, Hopkins PN, Arnett DK, et al: Chocolate consumption is inversely associated with calcified atherosclerotic plaque in the coronary arteries: The NHLBI Family Heart Study. Clin Nutr 2011, 30:38–43. This study showed for the first time an inverse association between chocolate consumption and subclinical atherosclerosis (coronary artery calcium).PubMedCrossRef
29.
Zurück zum Zitat •• Janszky I, Mukamal KJ, Ljung R,et al: Chocolate conusmption and mortality following a first acute myocardial infarction: the Stockholm Heart Epidemiology Program. J Intern Med 2009, 266:248–257. In this cohort study of 1169 non-diabetic patients who suffered non-fatal myocardial infarction, chocolate consumption was associated with a lower risk of mortality in a dose-dependent manner, with nearly 70% lower risk of death in people consuming chocolate 2 or more times per week. PubMedCrossRef •• Janszky I, Mukamal KJ, Ljung R,et al: Chocolate conusmption and mortality following a first acute myocardial infarction: the Stockholm Heart Epidemiology Program. J Intern Med 2009, 266:248–257. In this cohort study of 1169 non-diabetic patients who suffered non-fatal myocardial infarction, chocolate consumption was associated with a lower risk of mortality in a dose-dependent manner, with nearly 70% lower risk of death in people consuming chocolate 2 or more times per week. PubMedCrossRef
30.
Zurück zum Zitat Arts IC, Jacobs Jr DR, Harnack LJ, Gross M, Folsom AR. Dietary catechins in relation to coronary heart disease death among postmenopausal women. Epidemiology. 2001;12:668–75.PubMedCrossRef Arts IC, Jacobs Jr DR, Harnack LJ, Gross M, Folsom AR. Dietary catechins in relation to coronary heart disease death among postmenopausal women. Epidemiology. 2001;12:668–75.PubMedCrossRef
31.
Zurück zum Zitat Buijsse B, Feskens EJ, Kok FJ, Kromhout D. Cocoa intake, blood pressure, and cardiovascular mortality: the Zutphen elderly study. Arch Intern Med. 2006;166:411–7.PubMedCrossRef Buijsse B, Feskens EJ, Kok FJ, Kromhout D. Cocoa intake, blood pressure, and cardiovascular mortality: the Zutphen elderly study. Arch Intern Med. 2006;166:411–7.PubMedCrossRef
32.
Zurück zum Zitat Mink PJ, Scrafford CG, Barraj LM, et al. Flavonoid intake and cardiovascular disease mortality: a prospective study in postmenopausal women. Am J Clin Nutr. 2007;85:895–909.PubMed Mink PJ, Scrafford CG, Barraj LM, et al. Flavonoid intake and cardiovascular disease mortality: a prospective study in postmenopausal women. Am J Clin Nutr. 2007;85:895–909.PubMed
33.
Zurück zum Zitat Bayard V, Chamorro F, Motta J, Hollenberg NK. Does flavanol intake influence mortality from nitric oxide-dependent processes? Ischemic heart disease, stroke, diabetes mellitus, and cancer in Panama. Int J Med Sci. 2007;4:53–8.PubMed Bayard V, Chamorro F, Motta J, Hollenberg NK. Does flavanol intake influence mortality from nitric oxide-dependent processes? Ischemic heart disease, stroke, diabetes mellitus, and cancer in Panama. Int J Med Sci. 2007;4:53–8.PubMed
35.
Zurück zum Zitat Fisher ND, Hollenberg NK. Aging and vascular responses to flavanol-rich cocoa. J Hypertens. 2006;24:1575–80.PubMedCrossRef Fisher ND, Hollenberg NK. Aging and vascular responses to flavanol-rich cocoa. J Hypertens. 2006;24:1575–80.PubMedCrossRef
36.
Zurück zum Zitat Heiss C, Jahn S, Taylor M, et al. Improvement of endothelial function with dietary flavanols is associated with mobilization of circulating angiogenic cells in patients with coronary artery disease. J Am Coll Cardiol. 2010;56:218–24.PubMedCrossRef Heiss C, Jahn S, Taylor M, et al. Improvement of endothelial function with dietary flavanols is associated with mobilization of circulating angiogenic cells in patients with coronary artery disease. J Am Coll Cardiol. 2010;56:218–24.PubMedCrossRef
37.
Zurück zum Zitat Panneerselvam M, Tsutsumi YM, Bonds JA, et al. Dark chocolate receptors: epicatechin-induced cardiac protection is dependent on {delta}-opioid receptor stimulation. Am J Physiol Heart Circ Physiol. 2010;299:H1604–9.PubMedCrossRef Panneerselvam M, Tsutsumi YM, Bonds JA, et al. Dark chocolate receptors: epicatechin-induced cardiac protection is dependent on {delta}-opioid receptor stimulation. Am J Physiol Heart Circ Physiol. 2010;299:H1604–9.PubMedCrossRef
38.
Zurück zum Zitat Corti R, Flammer AJ, Hollenberg NK, Lusche TF. Cocoa and cardiovascular health. Circulation. 2009;119:1433–41.PubMedCrossRef Corti R, Flammer AJ, Hollenberg NK, Lusche TF. Cocoa and cardiovascular health. Circulation. 2009;119:1433–41.PubMedCrossRef
39.
Zurück zum Zitat Selmi C, Cocchi CA, Lanfredini M, Keen CL, Gershwin ME. Chocolate at heart: the anti-inflammatory impact of cocoa flavanols. Mol Nutr Food Res. 2008;52:1340–8.PubMedCrossRef Selmi C, Cocchi CA, Lanfredini M, Keen CL, Gershwin ME. Chocolate at heart: the anti-inflammatory impact of cocoa flavanols. Mol Nutr Food Res. 2008;52:1340–8.PubMedCrossRef
40.
Zurück zum Zitat Ried K, Frank O, Stocks N. Dark chocolate or tomato extract for prehypertension: a randomised controlled trial. BMC Complement Altern Med. 2009;9:22.PubMedCrossRef Ried K, Frank O, Stocks N. Dark chocolate or tomato extract for prehypertension: a randomised controlled trial. BMC Complement Altern Med. 2009;9:22.PubMedCrossRef
41.
Zurück zum Zitat Persson IA, Persson K, Hägg S, Andersson RG: Effects of Cocoa Extract and Dark Chocolate on Angiotensin-Converting Enzyme and Nitric Oxide in Human Endothelial Cells and Healthy Volunteers. J Cardiovasc Pharmacol 2010, In press. Persson IA, Persson K, Hägg S, Andersson RG: Effects of Cocoa Extract and Dark Chocolate on Angiotensin-Converting Enzyme and Nitric Oxide in Human Endothelial Cells and Healthy Volunteers. J Cardiovasc Pharmacol 2010, In press.
42.
Zurück zum Zitat •• Tokede OA, Gaziano JM, Djousse L: Effects of cocoa products/dark chocolate on serum lipids: A meta-analysis. Eur J Clin Nutr 2011, In press. This recent meta-analysis demonstrated beneficial effects of dark chocolate/cocoa products on total and LDL cholesterol and no major effects on HDL cholesterol and triglycerides. •• Tokede OA, Gaziano JM, Djousse L: Effects of cocoa products/dark chocolate on serum lipids: A meta-analysis. Eur J Clin Nutr 2011, In press. This recent meta-analysis demonstrated beneficial effects of dark chocolate/cocoa products on total and LDL cholesterol and no major effects on HDL cholesterol and triglycerides.
43.
Zurück zum Zitat Grassi D, Lippi C, Necozione S, Desideri G, Ferri C. Short-term administration of dark chocolate is followed by a significant increase in insulin sensitivity and a decrease in blood pressure in healthy persons. Am J Clin Nutr. 2005;81:611–4.PubMed Grassi D, Lippi C, Necozione S, Desideri G, Ferri C. Short-term administration of dark chocolate is followed by a significant increase in insulin sensitivity and a decrease in blood pressure in healthy persons. Am J Clin Nutr. 2005;81:611–4.PubMed
44.
Zurück zum Zitat di Giuseppe R, Di Castelnuovo A, Centritto F, et al. Regular consumption of dark chocolate is associated with low serum concentrations of C-reactive protein in a healthy Italian population. J Nutr. 2008;138:1939–45.PubMed di Giuseppe R, Di Castelnuovo A, Centritto F, et al. Regular consumption of dark chocolate is associated with low serum concentrations of C-reactive protein in a healthy Italian population. J Nutr. 2008;138:1939–45.PubMed
45.
Zurück zum Zitat Monagas M, Khan N, Andres-Lacueva C, et al. Effect of cocoa powder on the modulation of inflammatory biomarkers in patients at high risk of cardiovascular disease. Am J Clin Nutr. 2009;90:1144–50.PubMedCrossRef Monagas M, Khan N, Andres-Lacueva C, et al. Effect of cocoa powder on the modulation of inflammatory biomarkers in patients at high risk of cardiovascular disease. Am J Clin Nutr. 2009;90:1144–50.PubMedCrossRef
46.
Zurück zum Zitat Holt RR, Schramm DD, Keen CL, Lazarus SA, Schmitz HH. Chocolate consumption and platelet function. JAMA. 2002;287:2212–3.PubMedCrossRef Holt RR, Schramm DD, Keen CL, Lazarus SA, Schmitz HH. Chocolate consumption and platelet function. JAMA. 2002;287:2212–3.PubMedCrossRef
47.
Zurück zum Zitat Rein D, Paglieroni TG, Wun T, et al. Cocoa inhibits platelet activation and function. Am J Clin Nutr. 2000;72:30–5.PubMed Rein D, Paglieroni TG, Wun T, et al. Cocoa inhibits platelet activation and function. Am J Clin Nutr. 2000;72:30–5.PubMed
48.
Zurück zum Zitat Kelly FD, Sinclair AJ, Mann NJ, et al. A stearic acid-rich diet improves thrombogenic and atherogenic risk factor profiles in healthy males. Eur J Clin Nutr. 2001;55:88–96.PubMedCrossRef Kelly FD, Sinclair AJ, Mann NJ, et al. A stearic acid-rich diet improves thrombogenic and atherogenic risk factor profiles in healthy males. Eur J Clin Nutr. 2001;55:88–96.PubMedCrossRef
Metadaten
Titel
Chocolate and Coronary Heart Disease: A Systematic Review
verfasst von
Owais Khawaja
J. Michael Gaziano
Luc Djoussé
Publikationsdatum
01.12.2011
Verlag
Current Science Inc.
Erschienen in
Current Atherosclerosis Reports / Ausgabe 6/2011
Print ISSN: 1523-3804
Elektronische ISSN: 1534-6242
DOI
https://doi.org/10.1007/s11883-011-0203-2

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