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05.06.2019 | Original Paper

Choroidal thickness is associated with cardiovascular risk factors and cardiac health: the Gutenberg Health Study

Zeitschrift:
Clinical Research in Cardiology
Autoren:
Alexander K. Schuster, Anja Leuschner, Constantin Feretos, Philipp Blumenstein, Sven-Oliver Troebs, Sören Schwuchow, Andreas Schulz, Stefan Nickels, Alireza Mirshahi, Maria Blettner, Manfred E. Beutel, Karl J. Lackner, Thomas Münzel, Norbert Pfeiffer, Philipp S. Wild
Wichtige Hinweise

Electronic supplementary material

The online version of this article (https://​doi.​org/​10.​1007/​s00392-019-01498-8) contains supplementary material, which is available to authorized users.
Pfeiffer N. and Wild P.S. are senior authors.

Abstract

Background

Choroidal thickness is associated with several cardiovascular parameters in case–control studies including patients with manifest disease. So far, it was unclear whether underlying cardiovascular risk factors or the continuum of heart failure may lead to alterations of the choroid. Therefore, our hypothesis was to test in a population-based study, whether choroidal thickness is associated with cardiovascular risk factors and heart disease.

Methods

A population-based cross-sectional study was carried out in Germany. A comprehensive medical examination including assessment of cardiovascular risk factors, echocardiography and ophthalmological examinations with spectral-domain optical coherence tomography of the choroid was performed. Subfoveal choroidal thickness as well as left ventricular ejection fraction (LVEF) and a surrogate marker for left ventricular end-diastolic pressure (E/e’) were measured. Linear regression analyses were carried out to determine the relationship between subfoveal choroidal thickness and age, sex, body mass index, systolic blood pressure, dyslipidemia, HbA1c level, hematocrit, estimated glomerular filtration rate (eGFR), LVEF, E/e’ and left ventricular mass index adjusted for ocular parameters.

Results

1.742 subjects (48% females) with a mean age 59.3 ± 10.6 years were included in this study. Mean subfoveal thickness was 252 ± 77 µm (right eyes) and 255 ± 77 µm (left eyes). Unadjusted linear regression analysis revealed that subfoveal choroidal thickness is associated with sex, age, systolic blood pressure, hematocrit, eGFR, left ventricular end-diastolic pressure, left ventricular mass index (all p < 0.001) and dyslipidemia (p = 0.009). Adjusted linear regression only revealed age as associated parameter (p < 0.001).

Conclusions

We did find evidence for an association between subfoveal choroidal thickness and cardiovascular risk factors which was mediated by aging.

Graphic abstract

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Zusatzmaterial
Supplementary material 1 (DOCX 11 kb)
392_2019_1498_MOESM1_ESM.docx
Literatur
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