Erschienen in:
01.11.2006 | Oral Presentation
Chromosome translocations may play a significant role in breast cancer
verfasst von:
KL Howarth, KA Blood, JC Pole, SL Cooke, Y-L Chua, JC Beavis, B-L Ng, PAW Edwards
Erschienen in:
Breast Cancer Research
|
Sonderheft 2/2006
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Excerpt
Chromosome translocations that form fusion transcripts and/or activate expression of genes by promoter insertion are key events in leukaemias and lymphomas, and mesenchymal tumours, but it has been fashionable to think they are irrelevant to the common epithelial cancers such as breast cancer. However, that view is now being challenged [
1‐
4]; in particular, we have shown that
NRG1 is translocated in breast cancers [
3]. It seems likely that some translocations in breast cancers target specific genes at their breakpoints, and this is particularly likely for reciprocal translocations. …