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23.01.2017 | Novel Aspects in Lupus, 2017

Chronic hepatitis C viral infection among SLE patients: the significance of coexistence

verfasst von: Naim Mahroum, Ashraf Hejly, Shmuel Tiosano, Omer Gendelman, Doron Comaneshter, Arnon D. Cohen, Howard Amital

Erschienen in: Immunologic Research | Ausgabe 2/2017

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Abstract

The association between viral infection and autoimmune diseases is an established phenomenon in medicine. Hepatitis C viral infection is known to have such an association; however, its association with systemic lupus erythematosus has not been studied in a real life study driven from a large national database. The objective of this study was to investigate the association between SLE and chronic hepatitis C viral infection. Patients with SLE were compared with age- and sex-matched controls regarding the proportion chronic HCV infection. Chi-square and t tests were used for univariate analysis, and a logistic regression model was used for multivariate analysis. The study was performed utilizing the medical database of Clalit Health Services in Israel. There was a significant higher proportion of hepatitis C viral infection in SLE patients as compared to controls (1.06 and 0.39%, respectively; p < 0.001). A significant association was also observed among patients of higher socioeconomic status. In a multivariate logistic regression analysis, SLE was significantly associated with hepatitis C viral infection (OR = 2.07, 95% CI = 1.46–2.90). To conclude, Patients with SLE have a greater proportion of chronic HCV infection than matched controls.

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Titel: Chronic hepatitis C viral infection among SLE patients: the significance of coexistence
verfasst von: Naim Mahroum
Ashraf Hejly
Shmuel Tiosano
Omer Gendelman
Doron Comaneshter
Arnon D. Cohen
Howard Amital
Publikationsdatum: 23.01.2017
Verlag: Springer US
Erschienen in: Immunologic Research / Ausgabe 2/2017
Print ISSN: 0257-277X
Elektronische ISSN: 1559-0755
DOI: https://doi.org/10.1007/s12026-016-8886-7

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Chronic hepatitis C viral infection among SLE patients: the significance of coexistence

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