Skip to main content
Erschienen in: Journal of Nephrology 4/2018

01.08.2018 | Original Article

CKD-MBD management: what is the role of parathyroidectomy? Results from a nationwide survey in Italy

verfasst von: Antonio Bellasi, Luigi Morrone, Maria Cristina Mereu, Carlo Massimetti, Elena Pelizzaro, Giuseppe Cianciolo, Marzia Pasquali, Vincenzo Panuccio, on behalf of the working group on CKD-MBD of the Italian Society of Nephrology

Erschienen in: Journal of Nephrology | Ausgabe 4/2018

Einloggen, um Zugang zu erhalten

Abstract

We herein report on a nationwide survey conducted in Italy to investigate the use of parathyroidectomy (PTX). In spite of the availability of newer and more effective drugs to control chronic kidney disease mineral bone disorder (CKD-MBD) biochemical abnormalities, PTX still remains a resource for nephrologists to use. However, observational analyses suggest that in recent years there has been a constant decline in the number of patients undergoing PTX. The reasons are not clear, though the increasing age and number of comorbidities of dialysis patients may partly explain this trend. Poor adherence to guidelines and/or geographical as well as logistic factors may also contribute to the lower use of PTX. The working group on CKD-MBD of the Italian Society of Nephrology launched a nationwide survey to investigate clinical practice patterns for PTX in Italy and identify modifiable factors that may limit accessibility to surgery.
Anhänge
Nur mit Berechtigung zugänglich
Literatur
1.
Zurück zum Zitat Moe S, Drueke T, Cunningham J et al (2006) Definition, evaluation, and classification of renal osteodystrophy: a position statement from kidney disease: improving global outcomes (KDIGO). Kidney Int 69:1945–1953CrossRefPubMed Moe S, Drueke T, Cunningham J et al (2006) Definition, evaluation, and classification of renal osteodystrophy: a position statement from kidney disease: improving global outcomes (KDIGO). Kidney Int 69:1945–1953CrossRefPubMed
2.
3.
Zurück zum Zitat Block GA, Klassen PS, Lazarus JM et al (2004) Mineral metabolism, mortality, and morbidity in maintenance hemodialysis. J Am Soc Nephrol 15:2208–2218CrossRefPubMed Block GA, Klassen PS, Lazarus JM et al (2004) Mineral metabolism, mortality, and morbidity in maintenance hemodialysis. J Am Soc Nephrol 15:2208–2218CrossRefPubMed
4.
Zurück zum Zitat Cunningham J, Locatelli F, Rodriguez M (2011) Secondary hyperparathyroidism: pathogenesis, disease progression, and therapeutic options. Clin J Am Soc Nephrol 6:913–921CrossRefPubMed Cunningham J, Locatelli F, Rodriguez M (2011) Secondary hyperparathyroidism: pathogenesis, disease progression, and therapeutic options. Clin J Am Soc Nephrol 6:913–921CrossRefPubMed
5.
Zurück zum Zitat Ketteler M, Block GA, Evenepoel P et al (2017) Executive summary of the 2017 KDIGO Chronic Kidney Disease-Mineral and Bone Disorder (CKD-MBD) Guideline Update: what’s changed and why it matters. Kidney Int 92:26–36CrossRefPubMed Ketteler M, Block GA, Evenepoel P et al (2017) Executive summary of the 2017 KDIGO Chronic Kidney Disease-Mineral and Bone Disorder (CKD-MBD) Guideline Update: what’s changed and why it matters. Kidney Int 92:26–36CrossRefPubMed
6.
Zurück zum Zitat Kidney Disease: Improving Global Outcomes CKDMBDWG (2009) KDIGO clinical practice guideline for the diagnosis, evaluation, prevention, and treatment of Chronic Kidney Disease-Mineral and Bone Disorder (CKD-MBD). Kidney Int Suppl S1–130 Kidney Disease: Improving Global Outcomes CKDMBDWG (2009) KDIGO clinical practice guideline for the diagnosis, evaluation, prevention, and treatment of Chronic Kidney Disease-Mineral and Bone Disorder (CKD-MBD). Kidney Int Suppl S1–130
7.
Zurück zum Zitat Cozzolino M, Tomlinson J, Walsh L et al (2015) Emerging drugs for secondary hyperparathyroidism. Expert Opin Emerg Drugs 20:197–208CrossRefPubMed Cozzolino M, Tomlinson J, Walsh L et al (2015) Emerging drugs for secondary hyperparathyroidism. Expert Opin Emerg Drugs 20:197–208CrossRefPubMed
8.
Zurück zum Zitat Tartaglione L, Pasquali M, Rotondi S et al (2017) Positioning novel biologicals in CKD-mineral and bone disorders. J Nephrol 30:689–699CrossRefPubMed Tartaglione L, Pasquali M, Rotondi S et al (2017) Positioning novel biologicals in CKD-mineral and bone disorders. J Nephrol 30:689–699CrossRefPubMed
9.
Zurück zum Zitat Apetrii M, Goldsmith D, Nistor I et al (2017) Impact of surgical parathyroidectomy on chronic kidney disease-mineral and bone disorder (CKD-MBD) - A systematic review and meta-analysis. PLoS One 12:e0187025CrossRefPubMedPubMedCentral Apetrii M, Goldsmith D, Nistor I et al (2017) Impact of surgical parathyroidectomy on chronic kidney disease-mineral and bone disorder (CKD-MBD) - A systematic review and meta-analysis. PLoS One 12:e0187025CrossRefPubMedPubMedCentral
10.
Zurück zum Zitat Mazzaferro S, Brancaccio D, Messa P et al (2011) Management of secondary hyperparathyroidism in Italy: results of the Italian FARO survey. J Nephrol 24:225–235CrossRefPubMed Mazzaferro S, Brancaccio D, Messa P et al (2011) Management of secondary hyperparathyroidism in Italy: results of the Italian FARO survey. J Nephrol 24:225–235CrossRefPubMed
11.
Zurück zum Zitat Li S, Chen YW, Peng Y et al (2011) Trends in parathyroidectomy rates in US hemodialysis patients from 1992 to 2007. Am J Kidney Dis 57:602–611CrossRefPubMed Li S, Chen YW, Peng Y et al (2011) Trends in parathyroidectomy rates in US hemodialysis patients from 1992 to 2007. Am J Kidney Dis 57:602–611CrossRefPubMed
13.
Zurück zum Zitat Tentori F, Zepel L, Fuller DS et al (2015) The DOPPS practice monitor for US dialysis care: PTH levels and management of mineral and bone disorder in US hemodialysis patients. Am J Kidney Dis 66:536–539CrossRefPubMedPubMedCentral Tentori F, Zepel L, Fuller DS et al (2015) The DOPPS practice monitor for US dialysis care: PTH levels and management of mineral and bone disorder in US hemodialysis patients. Am J Kidney Dis 66:536–539CrossRefPubMedPubMedCentral
14.
Zurück zum Zitat Tentori F, Wang M, Bieber BA et al (2015) Recent changes in therapeutic approaches and association with outcomes among patients with secondary hyperparathyroidism on chronic hemodialysis: the DOPPS study. Clin J Am Soc Nephrol 10:98–109CrossRefPubMed Tentori F, Wang M, Bieber BA et al (2015) Recent changes in therapeutic approaches and association with outcomes among patients with secondary hyperparathyroidism on chronic hemodialysis: the DOPPS study. Clin J Am Soc Nephrol 10:98–109CrossRefPubMed
15.
Zurück zum Zitat Chertow GM, Block GA, Correa-Rotter R et al (2012) Effect of cinacalcet on cardiovascular disease in patients undergoing dialysis. N Engl J Med 367:2482–2494CrossRefPubMed Chertow GM, Block GA, Correa-Rotter R et al (2012) Effect of cinacalcet on cardiovascular disease in patients undergoing dialysis. N Engl J Med 367:2482–2494CrossRefPubMed
16.
Zurück zum Zitat Parfrey PS, Chertow GM, Block GA et al (2013) The clinical course of treated hyperparathyroidism among patients receiving hemodialysis and the effect of cinacalcet: the EVOLVE trial. J Clin Endocrinol Metab 98:4834–4844CrossRefPubMed Parfrey PS, Chertow GM, Block GA et al (2013) The clinical course of treated hyperparathyroidism among patients receiving hemodialysis and the effect of cinacalcet: the EVOLVE trial. J Clin Endocrinol Metab 98:4834–4844CrossRefPubMed
17.
Zurück zum Zitat van der Plas WY, Dulfer RR, Engelsman AF et al (2017) Effect of parathyroidectomy and cinacalcet on quality of life in patients with end-stage renal disease-related hyperparathyroidism: a systematic review. Nephrol Dial Transplant 32:1902–1908CrossRefPubMed van der Plas WY, Dulfer RR, Engelsman AF et al (2017) Effect of parathyroidectomy and cinacalcet on quality of life in patients with end-stage renal disease-related hyperparathyroidism: a systematic review. Nephrol Dial Transplant 32:1902–1908CrossRefPubMed
18.
Zurück zum Zitat Chen L, Wang K, Yu S et al (2016) Long-term mortality after parathyroidectomy among chronic kidney disease patients with secondary hyperparathyroidism: a systematic review and meta-analysis. Ren Fail 38:1050–1058CrossRefPubMed Chen L, Wang K, Yu S et al (2016) Long-term mortality after parathyroidectomy among chronic kidney disease patients with secondary hyperparathyroidism: a systematic review and meta-analysis. Ren Fail 38:1050–1058CrossRefPubMed
19.
Zurück zum Zitat Ishani A, Liu J, Wetmore JB et al (2015) Clinical outcomes after parathyroidectomy in a nationwide cohort of patients on hemodialysis. Clin J Am Soc Nephrol 10:90–97CrossRefPubMed Ishani A, Liu J, Wetmore JB et al (2015) Clinical outcomes after parathyroidectomy in a nationwide cohort of patients on hemodialysis. Clin J Am Soc Nephrol 10:90–97CrossRefPubMed
20.
Zurück zum Zitat Locatelli F, Messa P, Bellasi A et al (2013) What can we learn from a statistically inconclusive trial? Consensus conference on the EVOLVE study results. G Ital Nefrol 30 Locatelli F, Messa P, Bellasi A et al (2013) What can we learn from a statistically inconclusive trial? Consensus conference on the EVOLVE study results. G Ital Nefrol 30
21.
Zurück zum Zitat Belozeroff V, Chertow GM, Graham CN et al (2015) Economic Evaluation of Cinacalcet in the United States: The EVOLVE Trial. Value Health 18:1079–1087CrossRefPubMed Belozeroff V, Chertow GM, Graham CN et al (2015) Economic Evaluation of Cinacalcet in the United States: The EVOLVE Trial. Value Health 18:1079–1087CrossRefPubMed
22.
Zurück zum Zitat Gallieni M, De Luca N, Santoro D et al (2016) Management of CKD-MBD in non-dialysis patients under regular nephrology care: a prospective multicenter study. J Nephrol 29:71–78CrossRefPubMed Gallieni M, De Luca N, Santoro D et al (2016) Management of CKD-MBD in non-dialysis patients under regular nephrology care: a prospective multicenter study. J Nephrol 29:71–78CrossRefPubMed
23.
Zurück zum Zitat Li JG, Xiao ZS, Hu XJ et al (2017) Total parathyroidectomy with forearm auto-transplantation improves the quality of life and reduces the recurrence of secondary hyperparathyroidism in chronic kidney disease patients. Medicine (Baltimore) 96:e9050CrossRef Li JG, Xiao ZS, Hu XJ et al (2017) Total parathyroidectomy with forearm auto-transplantation improves the quality of life and reduces the recurrence of secondary hyperparathyroidism in chronic kidney disease patients. Medicine (Baltimore) 96:e9050CrossRef
24.
Zurück zum Zitat Minuto M, Vera L, Ansaldo GL et al (2014) Modern approach to parathyroidectomy. G Ital Nefrol 31 Minuto M, Vera L, Ansaldo GL et al (2014) Modern approach to parathyroidectomy. G Ital Nefrol 31
Metadaten
Titel
CKD-MBD management: what is the role of parathyroidectomy? Results from a nationwide survey in Italy
verfasst von
Antonio Bellasi
Luigi Morrone
Maria Cristina Mereu
Carlo Massimetti
Elena Pelizzaro
Giuseppe Cianciolo
Marzia Pasquali
Vincenzo Panuccio
on behalf of the working group on CKD-MBD of the Italian Society of Nephrology
Publikationsdatum
01.08.2018
Verlag
Springer International Publishing
Erschienen in
Journal of Nephrology / Ausgabe 4/2018
Print ISSN: 1121-8428
Elektronische ISSN: 1724-6059
DOI
https://doi.org/10.1007/s40620-018-0481-7

Weitere Artikel der Ausgabe 4/2018

Journal of Nephrology 4/2018 Zur Ausgabe

Leitlinien kompakt für die Innere Medizin

Mit medbee Pocketcards sicher entscheiden.

Seit 2022 gehört die medbee GmbH zum Springer Medizin Verlag

Blutdrucksenkung könnte Uterusmyome verhindern

Frauen mit unbehandelter oder neu auftretender Hypertonie haben ein deutlich erhöhtes Risiko für Uterusmyome. Eine Therapie mit Antihypertensiva geht hingegen mit einer verringerten Inzidenz der gutartigen Tumoren einher.

„Jeder Fall von plötzlichem Tod muss obduziert werden!“

17.05.2024 Plötzlicher Herztod Nachrichten

Ein signifikanter Anteil der Fälle von plötzlichem Herztod ist genetisch bedingt. Um ihre Verwandten vor diesem Schicksal zu bewahren, sollten jüngere Personen, die plötzlich unerwartet versterben, ausnahmslos einer Autopsie unterzogen werden.

Hirnblutung unter DOAK und VKA ähnlich bedrohlich

17.05.2024 Direkte orale Antikoagulanzien Nachrichten

Kommt es zu einer nichttraumatischen Hirnblutung, spielt es keine große Rolle, ob die Betroffenen zuvor direkt wirksame orale Antikoagulanzien oder Marcumar bekommen haben: Die Prognose ist ähnlich schlecht.

Schlechtere Vorhofflimmern-Prognose bei kleinem linken Ventrikel

17.05.2024 Vorhofflimmern Nachrichten

Nicht nur ein vergrößerter, sondern auch ein kleiner linker Ventrikel ist bei Vorhofflimmern mit einer erhöhten Komplikationsrate assoziiert. Der Zusammenhang besteht nach Daten aus China unabhängig von anderen Risikofaktoren.

Update Innere Medizin

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.