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16.07.2019 | Original Article

Clinical and molecular assessment of 13 Iranian families with Wolfram syndrome

verfasst von: Maryam Sobhani, Mohammad Amin Tabatabaiefar, Soudeh Ghafouri-Fard, Asadollah Rajab, Sarah Mozafarpour, Samaneh Nasrniya, Abdol-Mohammad Kajbafzadeh, Mohammad Reza Noori-Daloii

Erschienen in: Endocrine | Ausgabe 2/2019

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Abstract

Purpose

Wolfram syndrome (WS) is a rare genetic disorder described by a pattern of clinical manifestations such as diabetes mellitus, diabetes insipidus, optic nerve atrophy, sensorineural hearing loss, urinary tract abnormalities, and psychiatric disorders. WFS1 and WFS2 loci are the main genetic loci associated with this disorder.

Methods

In the current study, we investigated associations between these loci and WS via STR markers and homozygosity mapping in 13 Iranian families with WS. All families were linked to WFS1 locus.

Results

Mutation analysis revealed four novel mutations (Q215X, E89X, S168Del, and E391Sfs*51) in the assessed families. Bioinformatics tools confirmed the pathogenicity of the novel mutations. Other identified mutations were previously reported in other populations for their pathogenicity.

Conclusions

The current study adds to the mutation repository of WS and shows a panel of mutations in Iranian population. Such panel would facilitate genetic counseling and prenatal diagnosis in families with WS cases.

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Titel: Clinical and molecular assessment of 13 Iranian families with Wolfram syndrome
verfasst von: Maryam Sobhani
Mohammad Amin Tabatabaiefar
Soudeh Ghafouri-Fard
Asadollah Rajab
Sarah Mozafarpour
Samaneh Nasrniya
Abdol-Mohammad Kajbafzadeh
Mohammad Reza Noori-Daloii
Publikationsdatum: 16.07.2019
Verlag: Springer US
Erschienen in: Endocrine / Ausgabe 2/2019
Print ISSN: 1355-008X
Elektronische ISSN: 1559-0100
DOI: https://doi.org/10.1007/s12020-019-02004-w

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